Category «Methylation»

MTHFR and Vaccinations

MTHFR and Vaccines

I recently read, for the million-teenth time, that anyone with an MTHFR polymorphism should not be vaccinated.  The argument always seems to be that those with decreased MTHFR enzyme activity cannot detoxify or handle a vaccination. This seems to be accepted as fact by some, but I hadn’t really read anything other than anecdotes about …

Choline – An essential nutrient

Choline-An Essential Nutrient

I just finished listening to an interesting podcast featuring Dr. Zeisel, a researcher at the NC Nutrition Research Institute.  The interview discussed the body’s need for choline and the impact of some genetic polymorphisms on our ability to produce it in the body.  So I decided to dig into this a little more and look …

MTHFR, Depression, and Homocysteine Levels

MTHFR polymorphisms, depression, and homocysteine -- study showing response to supplements

  An interesting study came out this year in the Journal of Clinical Psychiatry.  The study, Correlation of Clinical Response With Homocysteine Reduction During Therapy With Reduced B Vitamins in Patients With MDD Who Are Positive for MTHFR C677T or A1298C Polymorphism: A Randomized, Double-Bind, Placebo-Controlled Study, is available in full on the journal’s website. …

Folic Acid supplementation and your genes

The breakdown of folic acid depends on the DHFR gene, in which many people have polymorphisms.

Edited and updated: Oct. 10, 2016 There is a lot of swirl and talk about MTHFR mutations and avoiding folic acid.  I’m going to dig into the topic a bit and see what is found in research studies as well as the history of folic acid supplementation.  Then I will go into some of the …

MTHFR C677T: Not All Bad!

Much has been written about this polymorphisms, with websites and facebook groups named after it.  In fact, it was one of the first polymorphisms that I had heard about and was one of the reasons that I got the 23andMe testing in the first place.  Many people seem to think it is a ‘doom and …

MTR / MTRR – Homocysteine, methionine, and B12

Methionine is an essential amino acid that plays an integral part in the methylation pathway. S-adenosyl methionine (SAMe) is a derivative of methionine and is involved in many cellular pathways as a methyl donor. MTR (methionine synthase) and MTRR (methionine synthase reductase) code for enzymes work together in the methylation cycle. MTR works in the final step …

COMT – Genetic Connections to Neurotransmitter Levels

The COMT gene encodes an enzyme called catechol-O-methyltransferase  that is involved in breaking down the neurotransmitters dopamine, epinephrine, and norepinephrine.   The enzyme adds a methyl group (from SAM) to the dopamine, epinephrine, and norepinephrine, thus changing them into a different substance.  COMT is also involved in the metabolism of some drugs used for asthma, Parkinson’s, and …

Histamine intolerance and the methylation cycle

Histamine Intolerance - The genes and pathways of breaking down histamine.

Are you itching by the end of the day?  Miserable in the evening due to heartburn?  Nose constantly stuffy and drippy? Plagued by migraines? All of these (and more) can be related to histamine intolerance. First, symptoms of histamine issues can be more than just watery eyes and sneezing when the pollen count rises each spring. From …