Category «Methylation»

MTHFR Coffee with Eggs and Kale for Breakfast

Quick post this morning to recommend a good podcast to anyone looking into MTHFR variants.  Chris Masterjohn put out a well balanced and well-researched podcast a few weeks ago titled Living with MTHFR.  For those of you who don’t have two hours to listen to it, there is a transcript of the show, which is …

MTHFR and Vaccinations

I recently read, for the million-teenth time, that anyone with an MTHFR polymorphism should not be vaccinated.  The argument always seems to be that those with decreased MTHFR enzyme activity cannot detoxify or handle a vaccination. This seems to be accepted as fact by some, but I hadn’t really read anything other than anecdotes about …

Choline – An essential nutrient

I just finished listening to an interesting podcast featuring Dr. Zeisel, a researcher at the NC Nutrition Research Institute.  The interview discussed the body’s need for choline and the impact of some genetic polymorphisms on our ability to produce it in the body.  So I decided to dig into this a little more and look …

MTHFR, Depression, and Homocysteine Levels

  An interesting study came out this year in the Journal of Clinical Psychiatry.  The study, Correlation of Clinical Response With Homocysteine Reduction During Therapy With Reduced B Vitamins in Patients With MDD Who Are Positive for MTHFR C677T or A1298C Polymorphism: A Randomized, Double-Bind, Placebo-Controlled Study, is available in full on the journal’s website. …

Folic Acid supplementation and your genes

There is a lot of talk online about MTHFR variants and the need to avoid folic acid.  I’m going to dig into the topic a bit and see what is found in research studies, as well as look at the history of folic acid supplementation. Then I will go into some of the research studies …

MTHFR C677T: Not All Bad!

Much has been written about this variant, with websites and facebook groups named after it.  In fact, it was one of the first variants that I had heard about and was one of the reasons that I got the 23andMe testing in the first place.  Many people seem to think it is a ‘doom and …

MTR / MTRR – Homocysteine, methionine, and B12

Methionine is an essential amino acid that plays an integral part in the methylation pathway. S-adenosyl methionine (SAMe) is a derivative of methionine and is involved in many cellular pathways as a methyl donor. MTR (methionine synthase) and MTRR (methionine synthase reductase) code for enzymes work together in the methylation cycle. MTR works in the final step …

COMT – Genetic Connections to Neurotransmitter Levels

The COMT gene encodes the enzyme catechol-O-methyltransferase which is involved in breaking down the neurotransmitters dopamine, epinephrine, and norepinephrine. This enzyme adds a methyl group (from SAMe) to the dopamine, epinephrine, or norepinephrine molecules, thus changing them into a different substance. COMT is also involved in the metabolism of some drugs used for asthma, Parkinson’s, and high …

Histamine intolerance and the methylation cycle

Are you itching by the end of the day?  Miserable in the evening due to heartburn?  Nose constantly stuffy and drippy? Plagued by migraines? All of these (and more) can be related to histamine intolerance. First, symptoms of histamine issues can be more than just watery eyes and sneezing when the pollen count rises each spring. From …