Detox

CYP2C19 – Metabolizing medications

The CYP2C19 enzyme is responsible for the breakdown of several popular drugs including proton pump inhibitors (Prilosec, Nexium, Prevacid), certain anti-epileptics, and an antiplatelet drug (Plavix).  CYP2C19 is also involved in activating and breaking down some hormones such as progesterone. There are variants of the CYP2C19 gene that cause some people to be poor metabolizers and others to be fast metabolizers. You can have increased side effects (depending on the medication) either from being a slow metabolizer or a fast metabolizer.   For example, a fast metabolizer taking omeprazole to treat h. pylori may have an insufficient response due to the drug not remaining active in the body long enough.[ref]  Alternatively, some drugs such as Plavix are converted into their active drug state through CYP2C19, and being a poor metabolizer could mean that Plavix (an anticoagulant) isn't activated quickly enough. [ref] (more…)

By Debbie Moon, ago
Detox

Liver Detox Genes: CYP2C9 Genotypes and Drug Metabolism

Have you ever wondered why certain medications don't work well for you? Genetic variants can change how fast or how slow the medication is broken down in your body. CYP2C9 is a gene that codes for an enzyme that metabolizes quite a few medications in the liver as well as linoleic acid, arachidonic acid, and serotonin outside of the liver.[ref] Some of the most prescribed drugs metabolized with CYP2C9 include losartan (blood pressure), Warfarin, acenocoumarol, tolbutamide (Orinase), glipizide (Glucotrol), ibuprofen (Advil, Motrin), celecoxib (Celebrex), montelukast (Singulair), naproxen (Aleve).  A complete list can be found on Pharmacy Times. (more…)

By Debbie Moon, ago
Detox

Liver Detox Genes – CYP2D6

  The CYP2D6 enzymes metabolize about 25% of pharmaceutical drugs such as SSRI’s, opioids, tamoxifen, Nyquil, and beta blockers. It also metabolizes serotonin and neurosteroids (pregnenolone, cholesterol, androsterone, etc). There are several important polymorphisms in CYP2D6 Read more…

By Debbie Moon, ago


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