Detox

Liver Detox Genes – CYP2D6

This is part of an ongoing series on the genes involved in detoxification. The CYP2D6 enzymes metabolize about 25% of pharmaceutical drugs such as SSRI’s, opioids, tamoxifen, Nyquil, and beta blockers.  It also metabolizes serotonin and neurosteroids (pregnenolone, cholesterol, androsterone, etc). There are several important polymorphisms in CYP2D6 which cause either Read more…

By Debbie Moon, ago
Detox

Liver Detox Genes – CYP2A6

This is part of an ongoing series on the genes involved in Phase I detoxification. The CYP2A6 enzyme is involved in the metabolism of nicotine, several cancer drugs,  valproic acid, and coumarin. (Full list of drugs on Wikipedia). The hormone estradiol is an inducer of CYP2A6, and women usually have a Read more…

By Debbie Moon, ago
Detox

Liver Detox Genes – CYP1A2

  This is part of an ongoing series on the genes involved in detoxification. The CYP1A2 enzyme is involved in the metabolism of xenobiotics (caffeine, aflatoxin B1, and acetaminophen) and is induced by the polycyclic aromatic hydrocarbons (PAH’s) that are found in cigarette smoke.  It metabolizes some PAH’s into carcinogenic Read more…

By Debbie Moon, ago
Detox

Liver Detox Genes – CYP1A1

This is part of an ongoing series on the genes involved in phase I and phase II detoxification. CYP1A1 is a gene that codes for the enzyme of the same name that is part of the phase I metabolism of some drugs and xenobiotics in the liver.  It is also involved Read more…

By Debbie Moon, ago
Detox

Liver Detox Genes – CYP2C19

This is part of an ongoing series of posts about the CYP450 enzymes and detoxification. The CYP2C19 enzymes are responsible for the breakdown of several popular drugs including some proton pump inhibitors (Prilosec, Nexium, Prevacid), anti-epileptics, and antiplatelet drugs (Plavix). There is a list on the Wikipedia page for CYP2D19. Read more…

By Debbie Moon, ago


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