Category «Disease Prevention»

Familial Mediterranean Fever: Do you carry the genetic variants?

familialMediterranean fever

Familial Mediterranean fever (FMF) is a genetic condition of inflammatory episodes that cause painful joints, pain in the abdomen, or pain in the chest, and is most often accompanied by a fever.  This condition often shows up first in childhood with unexplained fever and aches and pains. Genetics Home Reference explains “Familial Mediterranean fever is an inherited …

TNF-alpha Variants

TNFalpha

Tumor necrosis factor (TNF) is an inflammatory cytokine involved in our immune system.  In an acute inflammatory situation, TNF-alpha plays an essential role in protecting us.  The problems with TNF-alpha come when we have chronically elevated levels of this inflammatory cytokine.  This can lead to rheumatoid arthritis, heart disease, or autoimmune conditions. There are several genetic …

MTHFR and Vaccinations

MTHFR and Vaccines

I recently read, for the million-teenth time, that anyone with an MTHFR polymorphism should not be vaccinated.  The argument always seems to be that those with decreased MTHFR enzyme activity cannot detoxify or handle a vaccination. This seems to be accepted as fact by some, but I hadn’t really read anything other than anecdotes about …

Genetic Variants that Cause G6PD Deficiency

G6PD Deficiency

What is the G6PD gene? The G6PD gene codes for the glucose-6-phosphate dehydrogenase enzyme.  This gene is located on the X chromosome, so males will only have one copy of it and are more likely to be affected by it than females. The G6PD enzyme is part of the pentose phosphate pathway and supplies the …

Detoxifying Phthalates:  Genes and Diet

PhthalateGenetics

There have been several recent studies about phthalates that have piqued my interest lately.  I decided that it was time to look into the science behind the stories and see if there really is anything to the scare-tactic type headlines about phthalates.  Below are my notes with links to studies.  I encourage you to check …

Saturated Fat and Your Genes

SaturatedFatGenes

Recent articles on coconut oil and saturated fat being bad for you have been making waves lately via social media.  It has brought up once again the decades-long debate about which type of fat is best.  Those in the paleo and ketogenic world are quickly pointing out the flaws in the article, while most people remain …

Too much of a good thing: Mushrooms intolerance and your genes

mushroom_intolerance

I love mushrooms and can eat them in abundance – especially sauteed in a little butter with some salt sprinkled on them!  Yum!  So I was fascinated to read a study that linked mushrooms, a certain gene variant, and Crohn’s disease symptoms. The study, Mushroom intolerance: a novel diet-gene interaction in Crohn’s disease, was published in …

Carbohydrate metabolism: Your genes play a role in insulin and blood glucose levels

Carbs

When it comes to advice about the best diet, the things that everyone seems to accept as gospel don’t always hold true when researchers actually look into them.  Take the glycemic index for example: Around since the 1980’s, accepted dogma holds that white bread will very quickly raise everyone’s blood glucose levels with a GI …

Interaction between high fat diet and ACE deletion

ACE-deletion

Wondering if you should cut down on red meat and fat to lower your blood pressure?  According to a new study, it could depend on your genes. A recent study in the Journal of the American Heart Association illustrates once again the interaction between genetics and diet.  The study looked at blood pressure measurements in …

Diet – Gene Interaction in Type 2 Diabetes Risk

T2DPufa

A new study just came out in the FASEB Journal that looked at the interaction between polyunsaturated fat and the Peroxisome Proliferator-Activated Receptor-γ Coactivator 1-α (PPARGC1A) gene.  The study found that those with the minor allele (C) of rs4235308 combined with a lower PUFA (polyunsaturated fatty acids) to saturated fat ratio cut their risk of type …