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High-fat diet, high blood pressure, and the ACE gene

Wondering if you should cut down on red meat and fat to lower your blood pressure? According to a new study, it could depend on your genes…

A recent study in the Journal of the American Heart Association illustrates the interaction between genetics and diet. The study looked at blood pressure measurements in twins on a higher carb diet compared to a higher saturated fat diet.

For the first six weeks of the study, the participants, who were non-obese twin pairs, ate a higher-carb diet which consisted of 55% carbohydrates, 30% fat, and 15% protein.  Blood pressure and other blood markers were measured at the end of the six weeks.

For the second half of the study, the participants switched to a higher-fat diet consisting of 40% carbohydrates, 45% fat, and 15% protein, with the fat mainly being saturated fat from red meat, sausage, bacon, and full-fat dairy.

ACE and blood pressure:

The level of ACE, or angiotensin-converting enzyme, was measured. This enzyme controls blood pressure by constricting blood vessels. ACE inhibitors are a common type of blood pressure medication that works by decreasing or inhibiting the angiotensin-converting enzyme. The ACE gene has a common variant referred to as the ACE deletion/insertion.


ACE Genotype Report:

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Lifehacks:

For those who have high blood pressure and ACE deletion (rs4343 G/G), this study indicates that eating a diet high in bacon, cheeseburgers, steaks, and ice cream may be the problem. Try switching to a low-fat diet and tracking your blood pressure for a few weeks to see if it helps.

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Why join Genetic Lifehacks?

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~ It gives you access to the full article, including the Genotype and Lifehacks sections.
~ You'll see your genetic data in the articles and reports.

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About the Author:
Debbie Moon is the founder of Genetic Lifehacks. Fascinated by the connections between genes, diet, and health, her goal is to help you understand how to apply genetics to your diet and lifestyle decisions. Debbie has a BS in engineering from Colorado School of Mines and an MSc in biological sciences from Clemson University. Debbie combines an engineering mindset with a biological systems approach to help you understand how genetic differences impact your optimal health.