Liver Detox Genes – CYP2D6

How we differ in our abilities to detox drugs, toxins, and our own hormones. Img. by
How we differ in our abilities to detox drugs, toxins, and our own hormones.
Img. by Tareq Saluhuddin

This is part of an ongoing series on the genes involved in detoxification.

The CYP2D6 enzymes metabolize about 25% of pharmaceutical drugs such as SSRI’s, opioids, tamoxifen, Nyquil, and beta blockers.  It also metabolizes serotonin and neurosteroids (pregnenolone, cholesterol, androsterone, etc).

There are several important polymorphisms in CYP2D6 which cause either extensive or very poor metabolism – or something in between.  There are both good and bad potential consequences of being a poor or extensive metabolizer.  Being a poor metabolizer may reduce the risk of some cancers such as bladder or lung.  On the other hand, it also may significantly increase the risk of Parkinson’s disease for those exposed to pesticides.

Knowing whether you’re a fast or slow metabolizer may make it easier to find the right dosage of certain medications.  There is a good list of drugs (substrates) metabolized by CYP2D6 on Wikipedia.

Check your 23andMe results for rs3892097:

  •  TT: CYP2D6*4 – poor metabolizer
  • CT:  typically intermediate metabolizer
  •  CC: extensive metabolizer

 

Check your 23andMe results for rs5030655

  •  – – : CYP2A6*6 – deletion, poor metabolizer

 

Check your 23andMe results for rs1065852:

  • AA: decreased or non-functioning
  • AG:  somewhat decreased
  • GG: normal

 

Check your 23andMe results for rs1135824:

  •  TT: normal
  • CT:  one copy of CYP2D6*3
  •  CC: two copies of CYP2D6*3, non-functioning

 

Check your 23andMe results for rs5030867:

  •  TT: normal
  • GT:  carrier of one CYP2D6*7 allele
  • GG: carrier of two CYP2D6*7, non-functioning

 

Check your 23andMe results for rs5030656:

  •  I I: normal
  • – I:  carrier of one CYP2D6*9 allele
  • – -: carrier of two CYP2D6*9, non-functioning

 

Check your 23andMe results for rs28371706:

  •  GG: normal
  •  AG:  carrier of one decreased or non-functioning allele
  •   AA: possibly decreased or non-functioning

There are many other, less common variants for CYP2D6.  You can check on CYP2D6 on SNPedia for more information.

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