Increased Inflammation and IL-17A Polymorphisms

Inflammation (1)

In looking into the effects of emulsifiers on our gut, I came across quite a few genetic polymorphisms that are involved in increased inflammation and increased risk of inflammatory bowel diseases.  IL-17A is one of these pro-inflammatory gene polymorphisms. IL-17A is a pro-inflammatory part of our immune system that, while necessary in times of injury …

Microbiome, genetics, and emulsifiers = obesity

The connection between your genes, your gut health, and emulsifiers added to processed food.

Recently, I listened to an interview (from 2015) of a scientist who did a study on emulsifiers and found that they can lead to low grade inflammation in the gut, especially in mice with certain immune system genes knocked out.   Light bulbs started going off!  Time to dig into the published research to see if there …

Checking Your Carrier Status for Genetic Diseases

Carrier Status

The term “carrier status” when applied to a genetic disease usually means looking at whether or not you are heterozygous (have one copy) for a mutation that causes a Mendelian genetic disease.  Generally, these are the rare diseases that you would need two copies of the variant to have the disease. Take cystic fibrosis as …

Vitamin C Levels and Your Genes

vitamin-cgenes

As the weather here turns colder, thoughts turn to preventing colds and the flu.  My “go to” method of preventing sickness has always been by loading up on vitamin C, even though recent studies haven’t really supported the idea that vitamin C increase immune function. At my house, if you have the sniffles it is …

Dyslexia – Genetic Connections

Genetics of Dyslexia

While dyslexia is known to run in families, the role of genetics in dyslexia is still being determined.  Here is a quick look at some of the genes thought to be involved in dyslexia, which affects around 10% of the population. Two of the genes (KIAA0319 and DCDC2) identified as probably playing a role in dyslexia …

Medium chain acyl-CoA dehydrogenase deficiency

Medium Chain Acyl-CoA Dehydrogenase Deficiency

Medium-chain acyl-COA dehydrogenase (MCAD) deficiency is an “inborn error of metabolism” in which there is an impaired ability to break down medium-chain fatty acids.  In a nutshell, the body can use either glucose (through glycolysis) or fatty acids (through beta oxidation) to begin producing energy in the mitochondria.  MCAD deficiency affects the body’s ability to …

Short-chain Acyl-CoA Dehydrogenase Deficiency – Inborn Errors of Metabolism

Inborn errors of metabolism - SCADD

  SCAD Deficiency Short Chain Acyl-CoA Dehydrogenase Deficiency (SCADD) is a disorder of fatty acid oxidation and mitochondrial energy production.  Think back to high school biology class when you learned that the mitochondria are the cellular “powerhouse”, making ATP or energy for our body.  That process of ATP production can begin with either glucose (sugar) …

Riboflavin, MTHFR, and other Genetic Polymorphisms

Riboflavin (Vitamin B2) helps some people with certain genetic polymorphisms.

Riboflavin (Vitamin B2) is a water soluble vitamin that is a co-factor for many enzymes in the body.  To put it in simpler terms: riboflavin is vitally important! Riboflavin is a ribose sugar bound to a flavin molecule.  It is the precursor to FMN (flavin mononucleotide) and FAD (flavin adenine dinucleotide), which are coenzymes involved …

Genetics of Biotin Deficiency

biotin-deficiency

Biotin, also known as vitamin B7 or vitamin H, is a cofactor which aids in the metabolism of fats, carbohydrates, and proteins.  Biotin deficiency due to diet is pretty rare, but eating raw egg whites for an extended period of time can deplete the body of biotin.  Foods that are high in biotin include egg …

Adiponectin levels, food choices, and genetics

food-choices

Adiponectin, a hormone discovered in the 1990’s, is secreted by adipose (fat) tissue.  It is an anti-inflammatory protein, protective against the effects of low-grade inflammation that are associated with obesity.  Although it is made in fat tissue, those who have more fat tissue usually have lower adiponectin levels.  It is thought that the lower adiponectin levels (and …