This is part of an ongoing series on the genes involved in detoxification.

UDP-glucuronosyltransferase (abbreviated UG/T) creates a glucuronidation reaction, which is a big part of phase II detoxification.  Once a drug, toxin, or other substance is broken down in a phase I reaction (see the CYP genes), the Phase II reactions further alter the substance so that it can be excreted from the body.

UG/T enzymes are important for getting rid of quite a few different medications as well as environmental chemicals such as BPA and other estrogen-mimicking compounds. These enzymes also are involved in our body’s natural process of eliminating bilirubin, estrogen metabolites, and other hormones.


There are quite a few genes involved in glucuronidation, and most are prefixed with UG/T.

UG/T1A1 is involved in the breakdown of bilirubin, estrogen, and several carcinogens. Gilbert’s Syndrome is associated with this gene and involves bilirubin not being broken down appropriately.  One study in 2009 showed that the levels of UG/T1A1 activity can be increased with cruciferous vegetables.  This may be one way that cruciferous veggies are protective against cancer.

Bilirubin, a substance that brings to mind jaundice in babies, is a breakdown product naturally caused in a body as it clears out aged red blood cells.  It is excreted in bile and the urine (this is what makes your poop brown).

UG/T1A1 is also responsible for the breakdown of BPA (in plastics) [ref].

Note: There is a common variant that causes decreased UG/T activity (Caucasians, Africans) called UG/T1A1*28. It is not included in 23andMe data, so even if the information below shows that you have no UG/T variants, this doesn’t give you the whole picture. In other words, if you carry a variant below, you know that you have decrease UG/T1A1 activity, but if you don’t carry the variants below, you can’t assume that you have normal UG/T1A1 enzyme activity.

Check your 23andMe results for rs4148323 (v4, v5):

  • A/A: UG/T1A1*6 – increased bilirubin level, Gilbert’s syndrome in Asian populations
  • A/G: Carrier of UG/T1A1*6 (somewhat reduced enzyme activity)
  • G/G: normal

Check your 23andMe results for rs4124874 (v4, v5):

  •  G/G: UG/T1A1*60[ref], reduced enzyme activity, increased bilirubin (Caucasian)[ref]
  •  T/T: normal

Check your 23andMe results for rs6742078 (v4, v5):

  •  T/T: reduced UG/T1A1 activity, increased gallstone risk (males)[ref]
  •  G/G: normal

 UG/T1A6 is also involved in transforming bilirubin, hormones, and certain drugs (aspirin, acetaminophen)  into water-soluble metabolites that can then be excreted from the body.  Studies on this gene also look at the polymorphisms in association with benzene poisoning.

Check your 23andMe results for rs887829 (v4, v5):

  •  T/T: higher serum bilirubin levels, protective against heart disease
  •  C/C: normal

Check your 23andMe results for rs17863783 (v4, v5):

  •  T-allele: protective against bladder cancer
  • G/G: normal

UG/T1A9:

Check your 23andMe results for rs6714486 (v4 only)

  • A/A: higher activity [ref] [ref]
  • T/T: normal

 


Lifehacks:

Cruciferous vegetables cause your body to increase the production of UG/T1A1. If you aren’t eating enough cruciferous veggies, supplements of I3C and DIM (diindolylmethane) are available. They are the specific part of cruciferous veggies that induce UG/T1A1. [ref]

More to read:
UG/T1a1 polymorphisms are important determinants of dietary carcinogen detoxification in the liver (2005)

Regulation of the UG/T1a1 Bilirubin-Conjugating Pathway (2006)


4 Comments

Stan · September 2, 2017 at 4:55 am

This is very helpful! Thank you!
Could you please fix the second link (for rs6742078) because the link is actually wrong (points to a different SNP query)?

    genelife · September 4, 2017 at 1:32 pm

    Thanks! Got the link to 23andMe fixed. Appreciate you letting me know.

Genetic Lifehacks | ADHD, pesticides, and genetic polymorphisms · June 12, 2015 at 6:03 pm

[…] are the posts related to CYP2E1 and UGT1A9.  I did not find a lot of concrete information on what the polymorphisms in either gene do as far […]

Detoxifying Phthalates:  Genes and Diet | Genetic Lifehacks · July 19, 2017 at 2:53 pm

[…] UGT enzymes involved in the glucuronidation (phase II metabolism) of phthalates include UGT1A9, UGT1A3, UGT1A7, UGT1A10, UGT2B7  — check out my article on UGT genes […]

Leave a Reply

Your email address will not be published. Required fields are marked *

Related Posts

Diet / Gene Interaction

Problems with IBS? Personalized solutions based on your genes

We tend to take happy bowels for granted — until something goes awry!  For many people, a daily battle seems to wage in their intestines. Pain, discomfort, bloating, diarrhea and/or constipation — known as IBS Read more…

Disease Prevention

The genetics of high triglycerides

Triglycerides are the main type of fat in your blood. Triglyceride is a general term for a type of lipid-containing three fatty acids (tri) bound to a glycerol.  Triglycerides are used by the body as Read more…

Disease Prevention

Are you a spicy food wimp?

Some people thrive on spicy foods — eating the ghost pepper salsa or ordering the ‘nuclear’ hot wings. Are these people just tougher? stronger? superior? Or are they the genetic oddities?  Personally, I say that there Read more…