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PMS, Genetics, and Solutions

Key takeaways:
~ PMS and PMDD impact the quality of life for about a third of women.
~ Genetic studies show that the heritability, or genetic component, of PMS is around 95%.
~ Importantly, there are research-backed, natural supplement and diet options to help mitigate PMS.

Premenstrual syndrome and premenstrual dysphoric disorder:

Premenstrual syndrome (PMS) is defined clinically as a condition occurring during the luteal phase of the menstrual cycle (before your period) causing physical and mood symptoms. Experts believe that PMS is caused by hormonal fluctuations during this phase of the menstrual cycle, possibly in combination with nutrient deficiencies.[ref]

Premenstrual dysphoric disorder (PMDD) is also called late luteal dysphoric disorder. It is a severe form of PMS that severely impacts quality of life.

PMS affects about 30-40% of women, while the rarer PMDD affects only 3-8%.[ref]

What role do genes play in PMS?

Research shows that there is a very strong genetic component to PMS, especially for a severe form of PMS called premenstrual dysphoric disorder (PMDD).

A 2011 study of twins estimated the heritability of PMS to be around 95%.[ref]

Is it all in your head?

Perhaps in a literal way…

It turns out that neurotransmitters cause some of the symptoms of PMS and PMDD. Both conditions are linked to physically altered neurotransmitter levels.

  • Serotonin is an important neurotransmitter involved in mood stability. Estrogen is a serotonin agonist, and fluctuations in estrogen levels also affect serotonin levels.
  • GABA, another neurotransmitter, is also involved in PMS symptoms for some.[ref]

Increased susceptibility to PMS and PMDD is linked to genetic variants in these neurotransmitter genes — and these genes may hold the clues to what to do about PMS symptoms.


PMS and PMDD Genotype report:

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Lifehacks: Natural solutions for PMS and PMDD

Genetics seems to play a bigger role in PMDD. For many of us, though, we may need to look further for solutions to PMS woes.

Research on Dietary interventions:

Shockingly (not!), a study found that women with PMDD tend to eat more right before their period.[ref]

Studies on different dietary patterns show that a standard Western diet with fast food, deli meats, and soda increases the symptoms of PMS considerably. If you eat a lot of fast food or junk food, cleaning up your diet and eating more whole foods, especially in the week before your period, may help considerably.[ref] Plan ahead on this so that you are prepared for cooking meals at home and have healthy options on hand.

Intermittent fasting or simply having a longer overnight fasting period may help with luteal phase cortisol levels.[ref] An example of this could be eating dinner earlier (by 6 pm) and not eating again until 9 am. This would give you an overnight fast of 15 hours.

Histamine intolerance and a low histamine diet:
PMS, especially for menstrual cramps, is closely linked to a high histamine burden. If the symptoms of histamine intolerance seem to fit you, a diet lower in histamines may help your PMS. Foods high in histamines (avoid for low histamine diet) include anything fermented (soy sauce, vinegar, wine, kombucha), lunch meats, tomatoes, oranges, strawberries, chocolate, and fish that is not completely fresh. You may find that eating a lower histamine diet in the week prior to your period may be enough to help with your symptoms.

Related article: Genetics and Histamine Intolerance

6 Natural Supplements backed by research for PMS:

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Related Article and Topics:

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Estrogen is usually thought of as the female hormone. While it is true women produce more estrogen than men, this applies to all of us. Estrogen – from how much is made to how it is broken down – is dependent on both genetics and lifestyle factors affecting both men and women.

9 Genetic Variants Associated with PCOS
Polycystic ovarian syndrome (PCOS) is an endocrine disorder that causes an increase in androgen hormone production in women. It affects 5 -10% of premenopausal women, and genetics plays a large role in whether you have PCOS.

Migraines
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About the Author:
Debbie Moon is the founder of Genetic Lifehacks. Fascinated by the connections between genes, diet, and health, her goal is to help you understand how to apply genetics to your diet and lifestyle decisions. Debbie has a BS in engineering from Colorado School of Mines and an MSc in biological sciences from Clemson University. Debbie combines an engineering mindset with a biological systems approach to help you understand how genetic differences impact your optimal health.