The problem with TNF-alpha comes when we have chronically elevated levels, leading to rheumatoid arthritis, heart disease, or autoimmune conditions.
TNF-alpha Genetic Variants:
There are several genetic variants linked to naturally higher levels of TNF-alpha. Below are just some of the variants, along with some of the studies on them.
rs1800629 (also known as -308) – The A allele generally has higher TNF-alpha, more likely to have problems with chronic inflammation.
Studies of specific inflammatory conditions show:
- Higher risk of: ulcerative colitis, celiac disease (note – must have HLA type also), septic shock, diabetic foot ulcers, asthma from polyurethane, Hashimoto’s thyroiditis, skin infections, periodontitis, asthma in children,
- Less likely to have: Malaria (half the risk), osteoporosis,
- Diet: “Carriers of -308 GG promoter variant of TNF-alpha gene have a better metabolic response than -308 GA obese with a high protein” and lower carb diet.
|Check your 23andMe results for rs1800629 (v.4 and v.5):
rs361525 (also known as -238) Carriers of the A allele generally have higher TNF -alpha levels [study]. Again, not all studies show this, but by far, the majority of studies point to the A allele being at a higher risk for inflammatory conditions such as an increased risk of psoriasis or COPD.
|Check your 23andMe results for rs361525 (v.4 and v.5):
rs1799964 (also known as -1031) C allele carriers have higher TNF-Alpha levels[study], which puts them at an increased risk for inflammatory conditions, such as of IBD, increased risk of congenital cytomegalovirus, and higher risk of acute coronary syndrome.
|Check your 23andMe results for rs1799964 (v.4 and v.5):
|Check your 23andMe results for rs1799724 (v.4 and v.5):
Diet and Lifestyle interventions for high TNF-alpha:
Rosmarinic acid (found in rosemary, basil, holy basil, lemon balm, and perilla oil) is a natural TNF-alpha inhibitor. In addition to adding herbs to your food, holy basil can be found in a tea (called Tulsi tea) or supplement. Examine.com has good information on rosmarinic acid.
Aged garlic extract was shown in a study to decrease TNF-alpha levels by 35% in a mouse study and other studies. You can find aged black garlic at grocery stores, and it is available as a supplement if you don’t like the taste of aged garlic.
Glycine has been shown to reduce TNF-alpha and inflammation. Glycine is an amino acid that is abundant in bone broth and gelatin. My favorite way to increase my intake of gelatin is to dissolve it in my coffee each morning. Here is one that I usually use: Zint Beef Gelatin.
Low magnesium levels may play a role in higher TNF-alpha levels. Magnesium sulfate, in conjunction with thyroid medication, in hypothyroid rats, decreased TNF-alpha levels. My favorite way to use magnesium as a supplement is to make a spray using vodka with as much magnesium chloride as possible dissolved in it. Google “Mag-A-Hol” if you want to read more about it.
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