A recent article on Science Daily caught my eye: Study links exposure to common pesticides to ADHD in boys.  The article goes on to describe a study that links exposure to pyrethroid to ADHD, especially in boys.

Pyrethroid is a generic term for an organic compound that is commonly used in household pesticides.  Permethrin is one type of  pyrethroid, and it is used in agriculture as an insecticide, as a household pesticide, and also to prevent fleas and ticks.   It works by slowing down the nervous system through activation of the sodium channel.  The FDA claims it is safe for humans and most mammals, with the exception of cats.

A study published in 2011 in the Journal of Agriculture and Food Chemistry points to pathways of metabolism of permethrin.  Phase I metabolism mainly uses CYP2E1, and Phase II metabolism is only through UG/T1A9. [ref]

I have been working on a series of posts about the detoxification pathways and the genes involved.  Putting together the pieces, I wonder if problems in the detox pathway contribute to the link to ADHD.  Funny thing –when looking at the UG/T enzymes and genetic polymorphisms, I had found out that cats lack this enzyme and that is why they can’t metabolize acetaminophen and,  apparently, permethrin either.  Makes sense now that you can use a dog flea collar on a cat.

Here are the posts related to CYP2E1 and UG/T1A9.  I did not find a lot of concrete information on what the polymorphisms in either gene do as far as the expression of the gene.  Hopefully this can help you get started in researching if this is an area that impacts you or your family.

Categories: Disease Prevention

Leave a Reply

Your email address will not be published. Required fields are marked *

Related Posts

Disease Prevention

Back Pain and Your Genes

For some people, back pain is a daily occurrence that drastically affects their quality of life. For others, it may be an intermittent nagging problem that pops up occasionally, often without rhyme or reason. If you Read more…

Disease Prevention

Heart attack risk and hantavirus protection

Say that you slip with the knife while cutting up an apple for lunch. Ouch. It may bleed a bit, but you know that pretty soon it will stop. A whole cascade of events takes place Read more…

Alzheimer's

Melatonin: Key to Health and Longevity

It seems like everything that I’ve written about lately has a common thread: melatonin. When I started weaving together all those melatonin threads, a big picture was revealed. You could say it is a… tapestry Read more…