Autoimmune & Inflammation

Genetics plays a big role in your immune system. For some, increased inflammation is due to genetic variants in the inflammatory-related genes.  In most autoimmune diseases, there is a combination of genetic susceptibility and environmental factors. Understanding the genetic variants that you carry may help you to find the right solutions for YOU. 

  • Genetics, chronic fatigue syndrome, and long-haul viruses
    A look into the science of the lingering effects triggered by viruses including chronic fatigue syndrome and long-haul viruses.
  • COVID-19 & Genetics: Who gets sick and why?
    Not everyone gets sick when exposed to the SARS-CoV-2 virus. While there are many factors that come into play here, research points to genetics as playing a role. Several good genetic studies have recently been released showing which genes are important in COVID-19 susceptibility. Learn more and check your genes.
  • Vaccines, Genetics, and Autoimmune Diseases: A roundup of the research
    A look into the research-backed studies showing how certain vaccines may slightly increase the absolute risk of autoimmune diseases in susceptible individuals. (Member’s article)
  • PTPN22 and Autoimmune Diseases
    The PTPN22 gene plays a pivotal role in that balance, and genetic variants (SNPs) in PTPN22 increase your risk of autoimmune conditions such as vitiligo, alopecia, RA, type 1 diabetes, and autoimmune thyroid diseases. (Member’s article)
  • Emulsifiers in Processed Foods: Your genes and your microbiome
    Emulsifiers, found in a lot of processed and packaged foods, can trigger an inflammatory response in the intestines based on whether you carry specific genetic variants.
  • TNF-alpha: Inflammation and Your Genes
    Do you feel like you are always dealing with inflammation? Joint pain, food sensitivity, etc? Perhaps you are genetically geared towards a higher inflammatory response. Tumor necrosis factor (TNF) is an inflammatory cytokine that acts as a signaling molecule in our immune system.
  • Zinc genes: The healing power of zinc
    Learn why zinc is important for your immune system and so much more. Find out how your genes impact your need for zinc and discover ways of boosting your zinc status. 
  • Immune System and Inflammation Topic Summary Report
    Utilize our Immune System and Inflammation Topic Summary Reports with your 23andMe or AncestryDNA genetic data to see which articles may be most relevant to you. These summaries are attempting to distill the complex information down into just a few words. Please see the linked articles for details and complete references. (Member’s article)
  • Rheumatoid Arthritis Genes
    Rheumatoid arthritis is caused by an immune system attack on the joints, causing thickening and inflammation of the joint capsule. It is caused by a combination of genetic susceptibility and environmental triggers. (Member’s article)
  • How to check your genetic raw data for celiac genes
    Celiac disease is caused by a combination of environmental factors (eating gluten, other factors) and having the genetic variants that cause susceptibility to the disease. Without the genetic susceptibility, you won’t have celiac.
  • HMGB1 gene: inflammatory response protein important in sepsis and COVID-19
    The HMGB1 protein has a unique role in activating the inflammatory response pathways. Increased HMGB1 levels will call up the troops for a big response to an infection. Discover how genetic variants of this protein vary the risk of cancer, inflammation, and sepsis to name a few.
  • Genetics and Mannose-Binding Lectin
    Mannose-binding lectin, also known as mannose-binding protein, is involved in the body’s innate defense against infections. Find out how genetic variants in this system increase your susceptibility to specific pathogens.