Autoimmune & Inflammation

Genetics plays a big role in your immune system. For some, increased inflammation is due to genetic variants in the inflammatory-related genes.  

In most autoimmune diseases, there is a combination of genetic susceptibility and environmental factors. Understanding the genetic variants that you carry may help you to find the right solutions for YOU. 

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Mast Cells: MCAS, Genetics, and Solutions

Mast cells are an important part of your innate immune system. They are front line defenders against pathogens and allergens. For some people, mast cells can be triggered too easily, giving allergy-like responses to lots of different substances.

Grass Allergies and Genetics

Does spring time leave you with watery eyes and and a runny nose due to grass allergies? It could be due to certain genetic variants that increase the risk of allergies to grasses.

General Genetic Risk Factor for Autoimmune Diseases (CTLA-4 gene)

The CTLA4 gene codes for a protein that is important in the immune system. It acts as a checkpoint that can downregulate your immune system response. Genetic variants in the CTLA4 gene can increase your risk for several different autoimmune diseases.

Genetic Variants that Increase the Risk for Psoriasis

Psoriasis is an autoimmune condition that causes dry, sometimes itchy patches of skin. It is caused by the immune system attacking your skin cells, speeding up the turnover of the cells. Genetics plays a role in your susceptibility

HLA-B27 - check your 23andMe or AncestryDNA

HLA-B27: Increased risk of autoimmune diseases

Our immune system does an awesome job (most of the time) of fighting off pathogenic bacteria and viruses. But to fight off these pathogens, the body needs to know that they are the bad guys. This is where the HLA system comes in.

genetic variants 23andme TNF alpha

TNF-Alpha: Higher innate levels of this inflammatory cytokine

Do you feel like you are always dealing with inflammation? Joint pain, food sensitivity, etc? Perhaps you are genetically geared towards a higher inflammatory response. Tumor necrosis factor (TNF) is an inflammatory cytokine that acts as a signaling molecule in our immune system.

histamine intolerance genetics

Histamine Intolerance: Genetic variants linked to decreased histamine clearance

Plagued by histamine related symptoms such as sinus drainage, migraines, heart burn, and hives? Your genetic variants may be adding to your susceptibility to histamine intolerance.

Mast Cell Notes & Research

Mast cell activation can be at the root of many problems. This is a compilation of notes about causes of mast cell degranulation, ways to prevent mast cell degranulation, and the receptors that are involved.

Celiac Disease

Celiac disease is caused by a combination of environmental factors (eating gluten, other factors) and having the genetic variants that cause susceptibility to the disease. Without the genetic susceptibility, you won’t have celiac.

Back Pain

The majority of people by middle age have disc degeneration, but not everyone has pain from it. Your genes play a big role in whether you will feel the pain and inflammation in your back.

IL-17 and Autoimmune Disease Risk

The IL17 gene codes for an important part of the immune system. When it is overactive, IL-17 can contribute to the risk of autoimmune diseases including rheumatoid arthritis and inflammatory bowel disease.

Familial Mediterranean Fever

Familial Mediterranean fever (FMF) is a genetic condition of inflammatory episodes that cause painful joints, pain in the abdomen, or pain in the chest, and is most often accompanied by a fever. FMF is often misdiagnosed as various pain-related conditions such as fibromyalgia, myofascial pain syndrome, or gouty arthritis.