Glucuronidation: UGT genetic variants, phase II detoxification

The UGT family of enzymes are responsible for an important part of phase II detoxification. In this article, I’ll explain what the UGT enzymes do in the body, how your genes impact this part of detoxification, and lifestyle factors that can increase or decrease…

CYP2C8: Prescription medications and arachidonic acid

The CYP (cytochrome) family of genes codes for a number of different enzymes that interact with prescription drugs. This family of enzymes is important in breaking down medications in a process known as phase I detoxification. Genetic variants that alter the way that these…

NQO1 Gene: Metabolism of quinones, benzene, and more

Your genes code for the enzymes that break down the toxic substances that we all encounter each day. This ability to clear out potential carcinogens is important when it comes to preventing cancer. The NQO1 gene codes for an enzyme that breaks down quinones,…

Glyphosate: Interaction with Genetics

RoundUp is the most widely used herbicide in the world. It is made by Monsanto, which is now owned by Bayer. Glyphosate is the active ingredient in RoundUp, and it will kill most broadleaf plants and grasses. [ref] Glyphosate works by blocking the shikimate…

Should you eat organic? Genes that influence pyrethroid metabolism.

Is buying organic worth the extra cost? There isn’t a one-size-fits-all answer to that question. Pesticides that are sprayed on conventionally grown foods affect people differently. Some people carry genetic variants that decrease their ability to detoxify specific pesticides, others may be more resilient….

Should you eat organic? Detoxifying Organophosphates

Is buying organic worth the extra cost? There isn’t a one-size-fits-all answer to that question. Pesticides that are sprayed on conventionally grown foods affect people differently. Some people carry genetic variants that decrease their ability to detoxify specific pesticides, others may be more resilient….

CYP2D6: Metabolism of many OTC and prescription medicines

Say you aren’t feeling well, have had a cold for a week, and can’t sleep…  You’re just plain miserable.  And in your sleep deprived state, you decide to take some Nyquil (or another cough syrup containing dextromethorphan). Some people may get relief and finally get…

BPA: How Your Genes Influence BPA Detoxification

BPA, a chemical found in some plastics, has been linked to a variety of effects on people including obesity, insulin resistance, and epigenetic effects on the fetus.  It is everywhere in our food supply. In fact, a CDC report showed that 92% of people…

CYP3A4 and CYP3A5: How genes impact prescription medications

Our bodies break down (metabolize) drugs and other toxins through a group of enzymes known as the CYP450 family. Different CYP enzymes break down different substances, and we all carry genetic variants that can impact whether we metabolize a drug quickly or slowly. The…

CYP2C19 – Metabolizing medications

The CYP2C19 enzyme is responsible for the breakdown of several popular drugs including proton pump inhibitors (Prilosec, Nexium, Prevacid), certain anti-epileptics, and an antiplatelet drug (Plavix).  CYP2C19 is also involved in activating and breaking down some hormones such as progesterone. There are variants of…