Vitamin K: CYP4F2 and VKORC1 Genetic Variants

Vitamin K1 is a fat-soluble vitamin that is needed by our bodies to synthesize the proteins responsible for blood coagulation.  Without vitamin K1, also known as phylloquinone, bleeding is hard to control.  We get vitamin K1 from eating green plants, as phylloquinone is a part…

FGF21 Gene Variant: Increased Sweet Consumption

Is it possible to eat more sweets and have a decrease in fat? A new study recently published in the journal Cell shows a genetic link to having a sweet tooth, but this sweet tooth gene comes with a nice twist: it causes a…

Are you at a higher risk for diabetes? Check your TCFL72 variants

Type-2 diabetes affects about 9% of the US population and millions of people worldwide. For the over 65 crowd, the statistics are even more startling: one in four has type-2 diabetes. While the overall numbers are scary, it is interesting to note that the…

Hacking BDNF for weight loss

Brain-derived neurotrophic factor (BDNF) is a fascinating growth hormone that performs many functions in our brain. Its involvement helps to support neurons and neuronal growth. In addition, it plays a role in long-term memory — and it also is important in obesity. Researchers refer…

Does eating meat put you at a higher risk for colon cancer?

The link between colon cancer and meat consumption has been trumpeted by vegetarians — and refuted by paleo fanatics. My question, as usual, is: “What role does genetics play?” The World Health Organization includes processed meat on its list of probable carcinogens. This is…

Weight Loss: Optimizing your diet based on your genes

Diet gurus, talking heads on TV, government food pyramids, and your friend who lost 20 pounds… What do they all have in common?  They all know the perfect diet that will whip you into shape and make you feel good. If that diet doesn’t…

Salt and High Blood pressure: Genes Make a Difference (Patrons only)

Salt: Is it good for you? Or is it putting you at risk of high blood pressure? There is an interesting new book out by Dr. James DiNicolantonio called The Salt Fix that makes the argument that the experts got it wrong as far…

Why Allegra may not work as well for you: genetics of ABCB1 proteins (Patrons only)

Ever wonder why a certain medication may work great for a friend and do nothing for you?  One reason could be your genes. Let’s take fexofenadine (Allegra) for example.  You have watery eyes and a drippy nose during spring allergy season and pop an…

Biohacks – Experiments and Optimizations Based on My Genetics

After three years of digging into genetics and learning all that I can about my genes, I wanted to get a little personal and share a few things that have worked for me. I would also love to hear back from all of you. …

Lactose Intolerance: The genetics of not producing lactase

Are you a milk drinker? Does pouring a cold glass of milk sounds good? Your genes control whether you are likely to produce lactase as an adult, and it is easy to check your 23andMe or other genetic data to see if you are likely…