Advanced Glycation End Products

Recent research shows that advanced glycation end products (AGEs) are a causative factor in many degenerative diseases – including almost all of the diseases associated with aging. AGEs have been linked to Alzheimer’s, heart disease, diabetes, chronic kidney disease, wrinkles and loss of skin…

High blood pressure due to AGTR1 gene variants

Blood pressure isn’t something that you think much about – unless your doctor is harping about it being high or low.  The CDC statistics, though, make a pretty compelling argument that a lot of us should be thinking about blood pressure. The CDC estimates…

NAD+ Reversing Aging? Overview of NR and NMN

NAD+ article including human studies on NR and NMN

Nicotinamide riboside (NR) and nicotinamide mononucleotide (NMN) are two supplements that have taken the longevity and anti-aging world by storm. With animal studies showing exciting results including reversal of age-related diseases, these supplements are an exciting glimpse into the future of reversing aging. Just…

The genetics of high triglycerides

Triglycerides are the main type of fat in your blood. Triglyceride is a general term for a type of lipid-containing three fatty acids (tri) bound to a glycerol.  Triglycerides are used by the body as energy. They are also stored in fat cells. Most…

C-Reactive Protein Gene: Marker of Inflammation

Chronic inflammation is the driver of many common diseases such as heart attacks, diabetes, obesity, and autoimmune diseases. Measuring C-reactive protein (CRP) through a simple blood test is one way to know if you have a problem with chronic inflammation. It is an easy biomarker…

Prothrombin and DVT

You wake up one morning with a pain in your leg, trying to think back as to what you did the previous day to cause it.  Then you notice that your leg is a little swollen and warm…  Oh no, this could be the…

Factor V Leiden

Say you are chopping up peppers for your morning omelet and slip with the knife. Ouch! While cutting your finger seems to produce a huge amount of blood compared to the size of the wound, the actions going on behind the scenes to stop that…

The cheese effect and your genes.

Subtitled: Let’s all try not to have a heart attack this Christmas! Let me set the scene: You’re gathered ’round on Christmas Eve for a get together with all of your family, having traveled from far and wide. Your uncle brings his “special family recipe” of summer…

PCSK9 Gene Variants and Cholesterol

Just over fifteen years ago, researchers discovered that a mutation in PSCK9 gene caused really high cholesterol levels. This led to more discoveries about the gene and a fast-tracked medication for people with hypercholesterolemia.  [ref] What does PCSK9 do? The PCSK9 gene codes for…

Low HDL Levels Can Be Genetic

HDL cholesterol is known as the ‘good’ cholesterol. A study in the late 1970s/early 80s known as the Framingham Study determined that higher levels of HDL cholesterol were protective against heart disease. This is one of those studies that is foundational to a lot…