CYP2C19 – Metabolizing medications

The CYP2C19 enzyme is responsible for the breakdown of several popular drugs including proton pump inhibitors (Prilosec, Nexium, Prevacid), certain anti-epileptics, and an antiplatelet drug (Plavix).  CYP2C19 is also involved in activating and breaking down some hormones such as progesterone. There are variants of the CYP2C19 gene that cause some people to be poor metabolizers … Read more

CYP1A2 – Breaking down caffeine and more

The CYP1A2 enzyme is involved in the metabolism of xenobiotics (caffeine, aflatoxin B1, and acetaminophen) and is induced by the polycyclic aromatic hydrocarbons (PAH’s) that are found in cigarette smoke.  It metabolizes some pro-carcinogens into carcinogenic intermediates. CYP1A2 is also induced (activated) by cruciferous veggies such as cabbage, cauliflower, and broccoli.  It is inhibited by … Read more