Metformin

A decades-old diabetes drug now holds promise for increasing healthspan. Research shows that metformin may reduce the risk of some of the diseases of aging, thus increasing the number of years someone is healthy. What is metformin? Metformin, also known as Glucophage, is the…

Do you carry the Hunter-Gatherer or the Farmer Genetic Variant

Our ancient ancestors lived much differently than we do today. They were hunter-gatherers, living off of fish, meat, and plant foods that they gathered. A huge shift took place when those hunter-gatherers began farming, growing grains and storing them so that there would be…

Viruses: Are you susceptible to the coronavirus, flu, and more

With all the recent news coverage of the outbreak in Wuhan, you may be wondering if you are susceptible to the coronavirus. While you may think everyone catches a virus if exposed, your genes are actually important here as to whether or not you…

Should you vaccinate your kids if they have the MTHFR mutation?

You may have read or heard that anyone who carries MTHFR variants should not be vaccinated. Usually, the reason given is that those with decreased MTHFR enzyme activity cannot detoxify or ‘handle’ vaccinations, often with references to mercury in the vaccines. This article reviews…

Glucuronidation: UGT genetic variants, phase II detoxification

The UGT family of enzymes are responsible for an important part of phase II detoxification. In this article, I’ll explain what the UGT enzymes do in the body, how your genes impact this part of detoxification, and lifestyle factors that can increase or decrease…

Alpha-1 Antitrypsin Deficiency

A genetic mutation in the SERPINA1 gene causes alpha-1 antitrypsin deficiency. This increases a person’s susceptibility to COPD (chronic obstructive pulmonary disease) and, in some cases, cirrhosis of the liver. As far as rare mutations go, the alpha-1 antitrypsin deficiency mutations are fairly common…

Quercetin: Scientific studies + genetic connections

Quercetin is a natural flavonoid that acts both as an antioxidant and anti-inflammatory. This potent flavonoid is found in low levels in many fruits and vegetables, including elderberry, apples, and onions. As a supplement, quercetin has many positive health benefits. This article focuses on…

Plant Sterols for Lowering Cholesterol Depends on Genetics

One recommendation often made for lowering cholesterol levels is to consume higher amounts of plant sterols.  You can find plant sterols in supplements such as beta-sitosterol or spreads like Benecol or SmartBalance margarine. These butter alternatives are marketed as a heart-healthy way to help…

CYP2C8: Prescription medications and arachidonic acid

The CYP (cytochrome) family of genes codes for a number of different enzymes that interact with prescription drugs. This family of enzymes is important in breaking down medications in a process known as phase I detoxification. Genetic variants that alter the way that these…

Uterine fibroids

Uterine fibroids are a problem for a lot of women, especially after age 30. Fibroids are benign tumors that grow in the muscle cells of the uterus. While estimates vary, at least half of American women who are of reproductive age have fibroids. [ref…