Adiponectin levels, glucose regulation, and your genes

Adiponectin, a hormone secreted from adipose (fat) tissue, is involved in glucose regulation.  Studies show that low levels of adiponectin correlate with insulin resistance and diabetes.  Interestingly, although adiponectin is secreted from adipose tissue, levels of the hormone are generally lower in obese individuals….

Osteoporosis Genes

Osteoporosis is a degenerative bone disease facing many of us as we age. Affecting about 54 million people in the US currently, this is a disease that is estimated to affect 50% of women and 25% of men in their lifetime. The good news…

Type II Diabetes – Genetic Connections

According to the American Diabetes Association, 9.3% of the US population has diabetes (2012 numbers).  Diabetes was the 7th leading cause of death in the US in 2010.  The genes involved in increasing risk for type-2 diabetes indicate some of the variations in causes:…

Hearing Loss, Mitochondrial Function, and Sirtuins

Your mitochondria (the ‘powerhouse of the cell’) are vital to healthy longevity. Many chronic illnesses, as well as just general problems associated with aging, are due to a decline in mitochondrial function. Mitochondria, Energy Production, and Sirtuins: Within the mitochondria, molecules are converted into…

MTHFR Polymorphisms – Beyond 677

Going beyond MTHFR 677 and 1298 If you are just getting started with researching your MTHFR polymorphisms, you may want to start with some background information.  I have a list of resources on the MTHFR page that you might find helpful. MTHFR is a…

Phase II Detox – NATs

N-acetyltransferase is a phase II detoxification enzyme that helps to metabolize aromatic amines, drugs, cigarette smoke, and carcinogens. Basically, it makes specific toxins more water soluble so that they can be excreted through a process called acetylation. There are several common genetic variants that can classify…

ADHD, pesticides, and genetic polymorphisms

A recent article on Science Daily caught my eye: Study links exposure to common pesticides to ADHD in boys.  The article goes on to describe a study that links exposure to pyrethroid to ADHD, especially in boys. Pyrethroid is a generic term for an organic…

Phase II detox – GSTs

This is part of an ongoing series on the genes involved in detoxification. Another phase II detox reaction occurs with the glutathione S-transferases enzymes, which has eight classes identified: alpha, kappa, mu, omega, pi, sigma, theta, and zeta.  The classes are abbreviated with their first…

Nrf2 Pathway: Increasing the body’s ability to get rid of toxins

This is part of an ongoing series on the genes involved in detoxification. The Nrf2 (Nuclear factor erythroid 2–related factor) signaling pathway regulates the expression of antioxidants and phase II detoxification enzymes. This is a fundamental pathway that is important in how well your…

Liver Detox Genes – CYP2E1

This is part of an ongoing series on the genes involved in detoxification. The CYP2E1 gene codes for an enzyme (of the same name) that is involved in the metabolism of several important drugs as well as the conversion of ethanol to acetaldehyde.  CYP2E1…