HIF-1a: Hypoxia, Cancer, and Athletic Superpowers

When you think about things that you can’t live without, your iPhone or the internet may top the list :-) But really, oxygen tops all of our ‘can’t live without it’ lists.  A minute without it will remind you of just how important it…

NAD+ Reversing Aging? Overview of NR and NMN

NAD+ article including human studies on NR and NMN

Nicotinamide riboside (NR) and nicotinamide mononucleotide (NMN) are two supplements that have taken the longevity and anti-aging world by storm. With animal studies showing exciting results including reversal of age-related diseases, these supplements are an exciting glimpse into the future of reversing aging. Just…

NQO1 Gene: Metabolism of quinones, benzene, and more

Your genes code for the enzymes that break down the toxic substances that we all encounter each day. This ability to clear out potential carcinogens is important when it comes to preventing cancer. The NQO1 gene codes for an enzyme that breaks down quinones,…

Are your cavities caused by genetics?

Genetics and Cavities: Check your 23 and Me data

Friends accuse me of thinking that everything is genetic. Well – there is some truth to that accusation!  To be honest, though, there are a lot of things that have genetic connections that really surprise me. I had always assumed that my cavities were…

Privacy and Your Genes

privacy of your genetic data

I received an email from Promethease a few days ago that I wanted to share with all of you, along with my thoughts on keeping genetic data private. Genetics and Privacy: I’ve found in talking with people about genetics that there are often two…

Glyphosate: Interaction with Genetics

RoundUp is the most widely used herbicide in the world. It is made by Monsanto, which is now owned by Bayer. Glyphosate is the active ingredient in RoundUp, and it will kill most broadleaf plants and grasses. [ref] Glyphosate works by blocking the shikimate…

TNF-alpha: Inflammation and Your Genes

genetic variants 23andme TNF alpha

Do you feel like you are always dealing with inflammation? Joint pain, food sensitivity, etc? Perhaps you are genetically geared towards a higher inflammatory response. Tumor necrosis factor (TNF) is an inflammatory cytokine that acts as a signaling molecule in our immune system. In…

Estrogen: How it is made and how we get rid of it

genetics and estrogen metabolism

Estrogen is usually thought of as the female hormone. While it is true that women produce more estrogen than men, this is a topic that applies to all of us. Estrogen – from how much is made to how it is broken down –…

Gingivitis and Your Genes

Have you ever gone to the dentist, expecting a good report, only to be fussed at by the hygienist for bleeding gums? You brushed, flossed, and stayed away from candy for the past six months — so why on earth do you still have…

Longevity and Genetics: FOXO3, CETP, IGF1, and more

There are several genes known as “longevity” genes. Specific variants of these genes are associated with an increased likelihood of living to be 100 or more. And…  more importantly, these genetic variants are linked to longer ‘healthspan’. Longevity: The term longevity refers to lifespan….