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Coffee: Benefits based on your genes

Coffee: good or bad for you? Coffee is one of the most popular beverages in the world, second only to tea. However, it is sometimes controversial because of its caffeine content.

Large population studies have shown many benefits of coffee consumption, including a reduced risk of heart disease, endometrial cancer, diabetes, Parkinson’s disease, liver cancer, cirrhosis, prostate cancer, and stroke. On the other hand, large population studies often fail to account for an individual’s response to a substance, and the benefits of coffee may vary based on your genes.

Drinking Coffee: Good or Bad?

Studies have shown many benefits of coffee consumption, including decreased risk of:

  • endometrial cancer
  • diabetes
  • Parkinson’s disease,
  • liver cancer
  • cirrhosis
  • prostate cancer
  • stroke
  • heart disease

Antioxidants found in coffee:

Coffee is actually the “number one source of antioxidants in the U.S diet, according to a new study by researchers at the University of Stanton”.[ref]

In brewed coffee, several micronutrients, including potassium, magnesium, and niacin, are available in somewhat significant levels, but variations in soil nutrients, processing, and brewing do make a difference in the micronutrient levels per cup.[ref]

Caffeine affects people differently

Whether you start your morning with a cup of coffee or tea, caffeine remains the most popular ‘drug’ of choice for a large percentage of the population.

Caffeine wakes us up by blocking the adenosine receptor.

Caffeine also acts as a central nervous system stimulant, increasing reaction time.

Genetics determine how quickly your body processes and eliminates caffeine, and whether it makes you jittery or anxious.

Adenosine Receptors:

Adenosine is a molecule used in the body for a variety of purposes. One action of adenosine is that it makes us sleepy at the end of the day. Adenosine builds up in the brain over the course of the day and then is cleared out more quickly at night while we sleep. Higher levels of adenosine make us feel sleepy, driving us to go to sleep at night.

Caffeine can also bind to the adenosine receptors in the brain. When caffeine attaches to the adenosine receptor, it  blocks the receptor, making you feel more alert.

Changes to the adenosine A2A receptor gene (ADORA2A) also give rise to variations in how we respond to caffeine.

Changes in how the adenosine receptor functions due to genetic variants (see the genotype report below) can alter a person’s response to caffeine, including whether coffee increases anxiety.[ref]

Caffeine Metabolism: CYP1A2

CYP1A2 is a phase I detoxification enzyme that breaks down caffeine, as well as several other important toxins such as aflatoxin B1 from mold.

When you consume caffeine, it undergoes a process called biotransformation, which involves several enzymatic reactions to break it down. CYP1A2 is the primary enzyme responsible for metabolizing caffeine in the liver, although other enzymes also contribute to a lesser extent.

CYP1A2 enzyme activity can vary between individuals due to genetic variants (below in the genotype report) and environmental factors. Some people may have a highly active CYP1A2 enzyme, which means they metabolize caffeine quickly, while others may have a less active enzyme, resulting in slower caffeine metabolism.

Will coffee cause your kidneys harm?

A 2023 study made headlines by saying that people with slower coffee metabolism were at a 3-fold increased risk of kidney failure when drinking 3 or more cups of coffee a day. When digging into the details, the study was conducted in ~600 people who had high blood pressure. The kidney function measurements were done in 22 people with slower CYP1A2 variants who drank 3 cups or more of coffee a day, and the results were compared to 17 people with fast CYP1A2 variants who also drank 3+ cups a day.[ref]

The kidney function measurements did decrease faster over the course of 7 years in those with the slow CYP1A2 variants. However, I’m not sure that these results warrant the scary headlines of being at a 3-fold risk of kidney failure for people drinking more coffee. The sample size was small, and CYP1A2 also breaks down other substances, such as mold toxins.


Coffee: Genotype Report

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Lifehacks:

Coffee consumption studies:

If your beverage of choice in the morning is coffee, here are some studies on the effects:

A meta-analysis showed that 4 cups of coffee per day decreased the risk of breast cancer in postmenopausal women by 10%. Another study indicates the reduction in risk (found to be closer to 30% for those drinking 5 cups a day) may be due to something else in coffee other than caffeine because other caffeinated drinks did not give the same result.[ref][ref]

For those with the BRCA1 mutation, one study found coffee consumption before age 35 for those with the C-allele reduced their relative risk of breast cancer by 64%.[ref]

Another meta-analysis found high coffee consumption may lead to a decreased risk of pancreatic cancer.[ref]

Don’t like coffee?

There may be genetics involved in that, also. Check out this article on bitter taste receptors, which impact how much coffee people are likely to drink.

Dark vs. Light Roasts: Which is best for antioxidants?

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Why join Genetic Lifehacks?

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~ It gives you access to the full article, including the Genotype and Lifehacks sections.
~ You'll see your genetic data in the articles and reports.

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Related Articles and Topics:

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Did you know that about 1 in 5 people will deal with an anxiety disorder at some point in life? From generalized anxiety to separation anxiety to panic disorder – there are underlying physiological and genetic factors involved.

Lactose Intolerance: The genetics of not producing lactase (members article)
Are you a milk drinker? Does pouring a cold glass of milk sound good? Your genes control whether you are likely to produce lactase as an adult, and it is very easy to check your 23andMe or other genetic data to see if you are likely to enjoy a big glass of milk.p


About the Author:
Debbie Moon is the founder of Genetic Lifehacks. Fascinated by the connections between genes, diet, and health, her goal is to help you understand how to apply genetics to your diet and lifestyle decisions. Debbie has a BS in engineering from Colorado School of Mines and an MSc in biological sciences from Clemson University. Debbie combines an engineering mindset with a biological systems approach to help you understand how genetic differences impact your optimal health.