CRISPR Babies and HIV Resistance

Headline news from two weeks ago proclaimed that the first genetically modified babies (twins) had been born in China. The CRISPR gene-editing tool was used on the embryo to edit the babies’ genome in such a way that they would be likely to be resistant to HIV.

I’m not going to go into the many moral and ethical issues that I think arise from modifying the human genome. I’ll link to some recent articles on the topic in the Read More section below, and you can decide for yourself what you think.

Instead, I’m going to explain which gene was edited and how you can find out from your 23andMe or AncestryDNA results if you already carry the mutation.

CCR5 gene, immune response

The gene that the scientist modified is the CCR5 gene. The modification using CRISPR alters the gene to be similar to a natural mutation referred to as the CCR5 Delta32 mutation. Carrying two copies of the Delta32 variant confers resistance to HIV.

The CCR5 (chemokine receptor type 5) gene codes for a protein on the cell membrane of white blood cells, specifically T-cells, macrophages, dendritic cells, eosinophils, and microglial cells. It is a part of your immune system’s response to foreign invaders, and it is also an essential part of the way that the HIV virus is able to hijack immune cells.

Attachment of HIV to a T-helper cell. Public Domain Image.

The first person in the world to be cured of HIV, the “Berlin Patient“, was Timothy Ray Brown, an American living in Berlin. While HIV-positive, he contracted leukemia, and in 2007 he was given a bone marrow transplant from a donor with two copies of the CCR5 Delta32 mutation. After 3 months, he no longer had detectable HIV in his blood.

The Delta32 variant is well studied on a variety of immune system topics. It is thought that the mutation first arose in Northern Europe and was preferentially passed on in Caucasian populations due to increasing resistance to smallpox.[ref] Others theorize that the mutation has been in the Caucasian population for more than a millennium.[ref][ref] The highest frequency of Delta32 variants is found in the Faroe Islands (Denmark) with 2.3% of the population being homozygous for the mutation.[ref]

Here are some of the recent studies on the CCR5 Delta32 variant (rs333):

  • People who are homozygous for the variant (two copies of the variant) have a reduced chance of getting HIV when exposed. This isn’t complete protection for everyone, but it is a very significant reduction in the risk of HIV.[ref][ref][ref]
  • People who carry one copy of the variant (heterozygous) have a slower progression from HIV to AIDs and a reduced risk of mortality.[ref][ref]
  • A preliminary (small) study found that carrying two copies of the Delta32 variant may make the hepatitis B vaccine less effective.[ref]
  • A small study shows that the Delta32 mutation may be protective against Crimean-Congo hemorrhagic fever.[ref]
  • Carriers of the Delta32 variant fared worse, though, with West Nile Virus.[ref]
  • Caucasian carriers of Delta32 may have a reduced risk of atherosclerosis.[ref] Asian carriers, though, may be at an increased risk for atherosclerosis.[ref]

Check your 23andMe data for the CCR5 Delta32 variant:

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Check your genetic data for rs333 (23andMe use  i3003626 v4, v5):

  • Insertion/Insertion  (either II or GTCAGTATCAATTCTGGAAGAATTTCCAGACA/GTCAGTATCAATTCTGGAAGAATTTCCAGACA): normal and not resistant to HIV
  • Insertion / Deletion (either DI or -/GTCAGTATCAATTCTGGAAGAATTTCCAGACA):  a slower progression from HIV to AIDs, reduced mortality risk from HIV
  • Deletion / Deletion (either DD or -/-): resistance to the common strains of HIV

Members: Your genotype for i3003626 is .

 


Read more:


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About the Author:
Debbie Moon is the founder of Genetic Lifehacks. Fascinated by the connections between genes, diet, and health, her goal is to help you understand how to apply genetics to your diet and lifestyle decisions. Debbie has a BS in engineering and an MSc in biological sciences from Clemson University. Debbie combines an engineering mindset with a biological systems approach to help you understand how genetic differences impact your optimal health.