Genetic variants about in the enzymes that break down drugs and toxins. These genetic differences are why some medications don’t work well for certain people. Our reactions to toxicants, such as pesticides, also relies on our genes.
We are exposed to many different man-made chemical compounds every day, with exposure to new toxicants being much higher than what our ancestors experienced. There are several common GST variants that decrease the function of the GST enzymes. (Member's only article)
How many cigarettes a day a person smokes – and how hard it is for them to quit – is at least party dependent on the CYP2A6 gene. This enzyme also metabolizes several important cancer drugs.
Have you ever wondered why certain medications don’t work well for you? Genetic variants can change how fast or how slow the medication is broken down in your body. Learn how the CYP2C9 variants impact quite a few prescription medications.
Ever wonder why a certain medication may work great for a friend and do nothing for you? One reason could be your genes involved in transporting the medication into and out of your cells. This article looks at the research studies on fexofenadine (Allegra) and the Multidrug Resistance Protein variants. (Members)
Our bodies break down (metabolize) drugs and other toxins through a group of enzymes known as the CYP450 family. Different CYP enzymes break down different substances, and we all carry genetic variants that can impact whether we metabolize a drug quickly or slowly. The CYP3A family of genes is involved in metabolizing about half of the drugs on the market today. Check your genes to see if you carry variants that impact the speed at which you metabolize medications.
Several popular drugs such as Prilosec, Nexium, and Plavix are metabolized by the CYP2C19 enzyme. There are important genetic variants in the CYP2C19 gene that changes how fast or slowly these drugs are broken down. Learn how these variants might affect their efficacy. (Member's only article)
Statins are one of the most prescribed medications in the world. One side effect of statins is myopathy, or muscle pain and weakness. Your genetic variants are important in whether you are likely to have side effects from statins.
Is buying organic worth the extra cost? There isn’t a one-size-fits-all answer to that question. Pesticides that are sprayed on conventionally grown foods affect people differently. Some people carry genetic variants that decrease their ability to detoxify specific pesticides, others may be more resilient….
The CYP2D6 enzyme is responsible for metabolizing about 25% of commonly used medications. There are several fairly common genetic variants in CYP2D6 that affect how quickly you will break down a drug.
This phase I detoxification gene is important in the breakdown of the hydrocarbons produced in smoke and air pollution. It also affects the metabolism of estrogen.
The UGT family of enzymes are responsible for an important part of phase II detoxification. This article explains what the UGT enzymes do in the body, how your genes impact this part of detoxification, and lifestyle factors that can increase or decrease this detox process.
The Nrf2 (Nuclear factor erythroid 2–related factor) signaling pathway regulates the expression of antioxidants and phase II detoxification enzymes. This is a fundamental pathway that is important in how well your body functions. Your genetic variants in the NFE2L2 gene impact this NRF2 pathway.
Your body’s reaction to opiates, such as oxycodone or hydrocodone, depends on the opioid receptor. Genetic variants in OPRM1 (opioid receptor, mu 1) change your response to opioids. This can mean more pain, which leads to increased dosages… and an increased risk of opiate dependence.
Phthalates are a type of chemical used as plasticizers to make plastics more pliable. There has been a lot of research on the endocrine-disrupting effects of phthalates. Your genetic variants may impact whether phthalates are a problem for you.
Glyphosate is the active ingredient in the herbicide Round-Up. A recent study showed that people with CYP1A1 genetic variants are more likely to have problems with acetylcholinesterase inhibition from glyphosate.
The NQO1 gene codes for an important enzyme in phase II detoxification. This enzyme is responsible for metabolizing the cancer-causing benzene (e.g. from air pollution) and cigarette toxins. Learn more and check your genes.
Is buying organic worth the extra cost? Pesticides that are sprayed on conventionally grown foods affect people differently. Some people carry genetic variants that decrease their ability to detoxify specific pesticides, others may be more resilient. (Members)
The CYP2C8 gene is important in the metabolism of several chemotherapy drugs (e.g. Taxol) as well as playing a role in the metabolism of NSAIDs. Genetic variants that alter the way that this enzyme works can impact your reaction to a medication.
Your body has an endocannabinoid system which involves your own naturally produced molecules that bind to the same receptors as the psychoactive component in cannabis. This article digs into the science of how cannabis affects your body and how your genes influence your reaction to cannabis.