Detoxification & Drug Metabolism Genes

Genetic variants about in the enzymes that break down drugs and toxins. These genetic differences are why some medications don’t work well for certain people. Our reactions to toxicants, such as pesticides, also relies on our genes. 

CYP2C9: Breaking down prescription medications

Have you ever wondered why certain medications don’t work well for you? Genetic variants can change how fast or how slow the medication is broken down in your body. Learn how the CYP2C9 variants impact quite a few prescription medications.

Why Allegra May Not Work Well for You

Ever wonder why a certain medication may work great for a friend and do nothing for you? One reason could be your genes involved in transporting the medication into and out of your cells. This article looks at the research studies on fexofenadine (Allegra) and the Multidrug Resistance Protein variants.

Statins and Muscle Pain: Genes that impact myopathy

Statins are one of the most prescribed medications in the world. One side effect of statins is myopathy, or muscle pain and weakness. Your genetic variants are important in whether you are likely to have side effects from statins.

Detoxifying Organophosphates

Is buying organic worth the extra cost? There isn’t a one-size-fits-all answer to that question. Pesticides that are sprayed on conventionally grown foods affect people differently. Some people carry genetic variants that decrease their ability to detoxify specific pesticides, others may be more resilient….

CYP2D6

The CYP2D6 enzyme is responsible for metabolizing about 25% of commonly used medications. There are several fairly common genetic variants in CYP2D6 that affect how quickly you will break down a drug.

CYP1A1

This phase I detoxification gene is important in the breakdown of the hydrocarbons produced in smoke and air pollution. It also affects the metabolism of estrogen.

Glucuronidation: A Phase II Detoxification Pathway

The UGT family of enzymes are responsible for an important part of phase II detoxification. This article explains what the UGT enzymes do in the body, how your genes impact this part of detoxification, and lifestyle factors that can increase or decrease this detox process.

NRF2 Pathway: Getting Rid of Toxins

The Nrf2 (Nuclear factor erythroid 2–related factor) signaling pathway regulates the expression of antioxidants and phase II detoxification enzymes. This is a fundamental pathway that is important in how well your body functions. Your genetic variants in the NFE2L2 gene impact this NRF2 pathway.

Phthalates: Eliminating this Endocrine Disruptor

Phthalates are a type of chemical used as plasticizers to make plastics more pliable. There has been a lot of research on the endocrine-disrupting effects of phthalates. Your genetic variants may impact whether phthalates are a problem for you.

Opioid Receptors: Genetic Variants That Impact Your Reactions to Opioid Medications

Your body’s reaction to opiates, such as oxycodone or hydrocodone, depends on the opioid receptor. Genetic variants in OPRM1 (opioid receptor, mu 1) change your response to opioids. This can mean more pain, which leads to increased dosages… and an increased risk of opiate dependence.

CYP2C8: A Phase I Detoxification Gene

The CYP2C8 gene is important in the metabolism of several chemotherapy drugs (e.g. Taxol) as well as playing a role in the metabolism of NSAIDs. Genetic variants that alter the way that this enzyme works can impact your reaction to a medication.

Genetics and Your Response to Cannabis

Your body has an endocannabinoid system which involves your own naturally produced molecules that bind to the same receptors as the psychoactive component in cannabis. This article digs into the science of how cannabis affects your body and how your genes influence your reaction to cannabis.