Longevity and Healthy Aging

Aging = Damage > Repair

Aging can be thought of as the time in life when cellular damage is greater than the body can repair.  This formula, though, doesn’t have to be set in stone for us.  

You can prevent the diseases of aging through optimizing your lifestyle and diet.

Learn how YOUR genes impact healthy aging, and then apply the research-based Lifehacks to optimize your health and prevent the diseases of aging.

Use your genetic data for healthy aging:

Members: See your Topic Summary for Longevity

Rapamycin, mTOR, and Your Genes

Rapamycin is an antibiotic that is used as an immunosuppressant, an anti-cancer agent, and to prevent blocked arteries. Rapamycin is now the focus of longevity and healthspan-extending research through its inhibition of mTOR.

Age Related Macular Degeneration Genes

AMD is the most common cause of blindness in the elderly. This article explains age-related macular degeneration, delves into the genetic risks, and then explains which supplements are likely to be protective and which may do more harm than good.

Ringing in your ears? Meniere's disease, tinnitus, and genetics

Vertigo, constant ringing, and nausea… It sounds like a trip on a roller coaster after drinking a cherry slushie! This describes everyday life for many people with Meniere’s disease, an inner ear disorder causing vertigo and ringing in the ear. Meniere’s can also cause pressure in the ear and possible hearing loss, most often striking people in their 40s and 50s.

Osteoporosis: genetics and bone health

Osteoporosis is a degenerative bone disease facing many of us as we age. Genetics plays a big role in susceptibility to osteoporosis. The good news here is that knowing where your genetic susceptibility lies can lead you to targeted, personalized solutions for osteoporosis.

NAD+ article including human studies on NR and NMN

Boosting NAD+ levels to fight the diseases of aging

Explore the research about how nicotinamide riboside (NR) and NMN are being used to reverse aging. Learn about how your genes naturally affect your NAD+ levels, and how this interacts with the aging process.


Alzheimer's Disease and the APOE gene

The APOE gene variants are tightly linked with the risk of Alzheimer's disease. Find out whether you carry the APOE risk type for Alzheimer's - and learn what all of us can do via diet and lifestyle to prevent this disease.

Longevity and Genetics

There is a lot of research going on right now to determine exactly why and how we age — and why some people naturally live longer. Several genes have been identified as longevity genes, linked to an increase in lifespan. Most importantly, these particular genetic variants show links to a longer ‘healthspan’. Check your genetic data to see if you carry the FOXO3A and IGF1R variants associated with healthy longevity.

telomeres and aging

Telomere Length: How Your Genes Affect Telomeres and Aging

Your telomeres are the region at the end of each chromosome that keeps your DNA intact when your cells divide. Telomeres that are too short cause cells to stop dividing. This causes some of the diseases of aging. Genetics plays a role here - along with diet and lifestyle. (Member's only article)

Metformin: From diabetes prevention to longevity drug

A decades-old diabetes drug now holds promise for increasing healthspan. Research shows that metformin may reduce the risk of some of the diseases of aging, thus increasing the number of years someone is healthy. Learn how your genes interact with metformin and whether you are at an increased risk of side effects from it.

Preventing Alzheimer's Disease

Billions of dollars have been spent in the last couple of decades has been spent on trying to find drugs to stop the tangled accumulation of beta-amyloid plaque without much success. A new direction of research is looking into the ties between circadian rhythm dysfunction and Alzheimer’s disease.

How light at night increases cancer risk

The World Health Organization (WHO) categorizes light at night as a probable carcinogen. Learn why dim light at night increases your risk of breast cancer -- and what you can do to easily reduce this risk.

Fisetin: Anti-aging senolytic and powerful antioxidant

Recent research on the flavanoid fisetin shows that it may be a potent supplement for improving health in aging. Fisetin has been shown to act as a senolytic, clearing out senescent cells in animal and cells studies.

Lithium: Alzheimer's prevention, telomeres

Several good studies link higher natural levels of lithium in the ground water to decreased Alzheimer's rate. Additionally, clinical trial on lithium for Alzheimer's show promise. Learn more and decide whether this may be a longevity supplement for you.

Klotho Protein: Longevity superpowers

The Klotho protein is involved in many of the diseases of aging. Learn more about this gene and find out how your Klotho variants may impact healthy aging. (Member's only article)

Advanced Glycation End Products (AGEs)

One cause of many of the diseases of aging is the buildup of advanced glycation end products (AGEs). Your genes interact with your diet - and cooking methods - in the build up of AGEs. Learn whether this is something that is important for you to focus on.


Genetic variants that protect against Alzheimer's

Just like there are genetic variants that increase the risk of Alzheimer's, there are also variants that protect against this disease. Check your genetic data to get a better picture of your risk factors. (Member's only article)

Autophagy: Clearing out the cellular waste

Just like you need to take out the trash and recycle your plastics and cans, your body also needs to clean up cellular waste and recycle proteins. This process is called autophagy, and it is incredibly important in preventing the diseases of aging. (Member's only article)

Wrinkles and Age Spot

Some people age naturally with beautiful looking skin. Others slather on creams and odd gunk in a futile battle to chase away wrinkles and age spots. What is the difference? Genetics and environmental factors, of course.(Member's only article)