Snips about SNPs: ADA gene and sleepiness

Do you wake up every morning feeling groggy?

Adenosine building up during the day is one thing that drives us to feel sleepy during the night. Then while you sleep, the adenosine is cleared out, leaving you refreshed and ready to go in the morning… for most people.

There is a genetic variant in the adenosine deaminase (ADA) gene that decreases the clearance rate of adenosine. People who carry the variant may get more slow-wave, deep sleep at night, but they also may need to sleep a little longer o feel refreshed the next morning.

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Check your genetic data for rs73598374 (23andMe v4, v5; AncestryDNA):

  • C/C: normal clearance of adenosine
  • C/T: reduced clearance of adenosine, more deep sleep but may feel sleepy when waking up[ref]
  • T/T: reduce clearance of adenosine, more deep sleep but may feel sleepy when waking up

Members: Your genotype for rs73598374 is .

Learn more about the genes that affect your sleep!

 

*SNP stands for Single Nucleotide Polymorphism, which is when one of the nucleotide bases (the A, C, G, or Ts) is replaced by a different nucleotide base in a gene. 

Want more quick bits about your genes? Read through all the Snips about SNPs



Author Information:   Debbie Moon
Debbie Moon is the founder of Genetic Lifehacks. She holds a Master of Science in Biological Sciences from Clemson University and an undergraduate degree in engineering. Debbie is a science communicator who is passionate about explaining evidence-based health information. Her goal with Genetic Lifehacks is to bridge the gap between the research hidden in scientific journals and everyone's ability to use that information. To contact Debbie, visit the contact page.