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Snips about SNPs: ADA gene and sleepiness

Do you wake up every morning feeling groggy?

Adenosine building up during the day is one thing that drives us to feel sleepy during the night. Then while you sleep, the adenosine is cleared out, leaving you refreshed and ready to go in the morning…for most people.

There is a genetic variant in the adenosine deaminase (ADA) gene that decreases the clearance rate of adenosine. People who carry the variant may get more slow-wave, deep sleep at night, but they also may need to sleep a little longer o feel refreshed the next morning.

Check your genetic data for rs73598374 (23andMe v4, v5; AncestryDNA):

  • C/C: typical clearance of adenosine
  • C/T: reduced clearance of adenosine, more deep sleep but may feel sleepy when waking up[ref]
  • T/T: reduce clearance of adenosine, more deep sleep but may feel sleepy when waking up

Members: Your genotype for rs73598374 is .

Learn more about the genes that affect your sleep.

 

*SNP stands for Single Nucleotide Polymorphism, which is when one of the nucleotide bases (the A, C, G, or Ts) is replaced by a different nucleotide base in a gene. 

Want more quick bits about your genes? Read through all the Snips about SNPs


About the Author:
Debbie Moon is the founder of Genetic Lifehacks. Fascinated by the connections between genes, diet, and health, her goal is to help you understand how to apply genetics to your diet and lifestyle decisions. Debbie has a BS in engineering from Colorado School of Mines and an MSc in biological sciences from Clemson University. Debbie combines an engineering mindset with a biological systems approach to help you understand how genetic differences impact your optimal health.