Snips about SNPs: Hangry Gene

Ever wonder how your friends can go all day without eating — or why they love intermittent fasting — when you get so irritable and grumpy?  Perhaps you have the “Hangry Gene”. Or, more accurately, perhaps you carry a genetic variant in the GNB3 gene that is linked to irritability and a bad mood when fasting.

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Check your genetic data for rs5443 (23andMe v4, v5; AncestryDNA):

  • C/C: best mood, least hunger
  • C/T: somewhere in the middle with more hunger than C/C
  • T/T: worst mood, most hunger when fasting – hangry [ref]

Members: Your genotype for rs5443 is .

Want more details? Check out the full article on fasting.

*SNP stands for Single Nucleotide Polymorphism, which is when one of the nucleotide bases (the A, C, G, or Ts) is replaced by a different nucleotide base in a gene.  Want to know more about your genes? Read through all the Snips about SNPs. 



Author Information:   Debbie Moon
Debbie Moon is the founder of Genetic Lifehacks. She holds a Master of Science in Biological Sciences from Clemson University and an undergraduate degree in engineering from Colorado School of Mines. Debbie is a science communicator who is passionate about explaining evidence-based health information. Her goal with Genetic Lifehacks is to bridge the gap between the research hidden in scientific journals and everyone's ability to use that information. To contact Debbie, visit the contact page.