Snips about SNPs: Hangry Gene

Ever wonder how your friends can go all day without eating — or why they love intermittent fasting — when you get so irritable and grumpy?  Perhaps you have the “Hangry Gene”. Or, more accurately, perhaps you carry a genetic variant in the GNB3 gene that is linked to irritability and a bad mood when fasting.

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Check your genetic data for rs5443 (23andMe v4, v5; AncestryDNA):

  • C/C: best mood, least hunger
  • C/T: somewhere in the middle with more hunger than C/C
  • T/T: worst mood, most hunger when fasting – hangry[ref]

Members: Your genotype for rs5443 is .

Want more details? Check out the full article on fasting.

*SNP stands for Single Nucleotide Polymorphism, which is when one of the nucleotide bases (the A, C, G, or Ts) is replaced by a different nucleotide base in a gene.  Want to know more about your genes? Read through all the Snips about SNPs.