Snips about SNPs: Heart attack risk – Lp(a)

Lipoprotein(a) carries LDL cholesterol proteins. Elevated Lp(a) is a big risk factor for heart attacks, and elevated Lp(a) is mainly due to genetics.  Check your 23andMe or AncestryDNA data today to see if you carry the genetic variants linked to elevated Lp(a). If you do? Time to talk to your doctor or go get a blood test done to find out your Lp(a) level.

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Check your genetic data for rs3798220  (23andMe v4, v5,AncestryDNA):

  • C/C: risk of elevated Lp(a), increased risk for heart disease – 3.7x risk of aortic stenosis[ref][ref]
  • C/T: risk of  elevated Lp(A), increased risk for heart disease, increased risk of aortic stenosis
  • T/T: typical

Members: Your genotype for rs3798220 is .

Check your genetic data for rs10455872 (23andMe v4, v5; AncestryDNA):

  • G/G: likely elevated Lp(a), increased risk for heart disease – 2x risk of aortic stenosis[ref][ref]
  • A/G: likely elevated Lp(A), increased risk for heart disease
  • A/A: typical

Members: Your genotype for rs10455872 is .

Want more details? Check out the full article on lipoprotein(a).

*SNP stands for Single Nucleotide Polymorphism, which is when one of the nucleotide bases (the A, C, G, or Ts) is replaced by a different nucleotide base in a gene.  Want to know more about your genes? Read through all the Snips about SNPs


Author Information:   Debbie Moon
Debbie Moon is the founder of Genetic Lifehacks. She holds a Master of Science in Biological Sciences from Clemson University and an undergraduate degree in engineering from Colorado School of Mines. Debbie is a science communicator who is passionate about explaining evidence-based health information. Her goal with Genetic Lifehacks is to bridge the gap between the research hidden in scientific journals and everyone's ability to use that information. To contact Debbie, visit the contact page.