Snips about SNPs: Heart attack risk – Lp(a)

check your genetic data for lp(a)

Lipoprotein(a) carries LDL cholesterol proteins. Elevated Lp(a) is a big risk factor for heart attacks, and elevated Lp(a) is mainly due to genetics.  Check your 23andMe or AncestryDNA data today to see if you carry the genetic variants linked to elevated Lp(a). If you do? Time to talk to your doctor or go get a blood test done to find out your Lp(a) level.

Check your genetic data for rs3798220  (23andMe v4, v5, AncestryDNA):

  • C/C: risk of elevated Lp(a), increased risk for heart disease – 3.7x risk of aortic stenosis [ref][ref]
  • C/T: risk of  elevated Lp(A), increased risk for heart disease, increased risk of aortic stenosis
  • T/T: normal

Check your genetic data for rs10455872 (23andMe v4, v5; AncestryDNA):

  • G/G: likely elevated Lp(a), increased risk for heart disease – 2x risk of aortic stenosis [ref][ref]
  • A/G: likely elevated Lp(A), increased risk for heart disease
  • A/A: normal

Want more details? Check out the full article on lipoprotein(a).

*SNP stands for Single Nucleotide Polymorphism, which is when one of the nucleotide bases (the A, C, G, or Ts) is replaced by a different nucleotide base in a gene.  Want to know more about your genes? Read through all the Snips about SNPs


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4 Comments on “Snips about SNPs: Heart attack risk – Lp(a)

  1. I am working on 4 different variant reports from both 23andme [unsure of version] and Ancestry DNA and these SNPs do not appear on any of them. I know that in at least 2 of the reports there are heart issues with parents so am really surprised not to see one of them in at least one of the reports. Any idea why they dont appear?

    • Hi June,
      I’m not sure what you are looking at for variant reports, so I can’t really comment on why they didn’t include the Lp(a) information.
      If you check your raw data file from 23andMe or from AncestryDNA, you should find these RS ids for the LPA gene variants.
      The research on Lp(a) and heart disease risk is pretty solid, but it is also fairly new (the majority of it within the last 5-6 years). So perhaps the reports that you have that don’t include Lp(a) for heart attack risk are focused more on older research.

    • Hi,
      There are other LPA mutations that are not covered by 23andMe or Ancestry type of data. (And I need to make that clearer in the article!) Odds are that you probably do carry one of those mutations. High Lp(a) levels are nearly always due to genetics.
      Here is a good explainer article about Lp(a) from a company in clinical trials for a genetic solution to high Lp(a) levels.
      Thanks for reading and commenting!

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