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Snips about SNPs: High Triglycerides and APOA5

The APOA5 gene codes for a lipoprotein that is important in triglyceride metabolism. A variant in the APOA5 gene is linked to higher triglyceride levels and also an increased risk of heart disease.[ref]

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Check your genetic data for rs662799 (23andMe v4, v5; AncestryDNA):

  • A/A: typical
  • A/G: increased triglyceride levels, 16% increase in triglyceride levels[ref]
  • G/G: increased triglyceride levels[ref][ref][ref], 32% increase in triglyceride levels[ref]

Members: Your genotype for rs662799 is .


Learn more about how your genes affect triglycerides and the steps that you can take to mitigate the impact.

*SNP stands for Single Nucleotide Polymorphism, which is when one of the nucleotide bases (the A, C, G, or Ts) is replaced by a different nucleotide base in a gene. 

Want more quick bits about your genes? Read through all the Snips about SNPs



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About the Author:
Debbie Moon is the founder of Genetic Lifehacks. Fascinated by the connections between genes, diet, and health, her goal is to help you understand how to apply genetics to your diet and lifestyle decisions. Debbie has a BS in engineering from Colorado School of Mines and an MSc in biological sciences from Clemson University. Debbie combines an engineering mindset with a biological systems approach to help you understand how genetic differences impact your optimal health.