Snips about SNPs: High Triglycerides and APOA5

The APOA5 gene codes for a lipoprotein that is important in triglyceride metabolism. A variant in the APOA5 gene is linked to higher triglyceride levels and also an increased risk of heart disease.  [ref]

Check your genetic data for rs662799 (23andMe v4, v5; AncestryDNA):

  • A/A: normal
  • A/G: increased triglyceride levels, 16% increase in triglyceride levels [ref]
  • G/G: increased triglyceride levels[ref][ref][ref], 32% increase in triglyceride levels[ref]

 

Learn more about how your genes affect triglycerides and steps that you can take to mitigate the impact.

*SNP stands for Single Nucleotide Polymorphism, which is when one of the nucleotide bases (the A, C, G, or Ts) is replaced by a different nucleotide base in a gene. 

Want more quick bits about your genes? Read through all the Snips about SNPs



Author Information:   Debbie Moon
Debbie Moon is the founder of Genetic Lifehacks. She holds a Master of Science in Biological Sciences from Clemson University. Debbie is a science communicator who is passionate about explaining evidence-based health information. Her goal with Genetic Lifehacks is to bridge the gap between scientific research and the lay person's ability to utilize that information. To contact Debbie, visit the contact page.