Snips about SNPs: Low LDL Cholesterol

Low LDL cholesterol throughout life and a decreased risk of heart disease? Sign me up! No, this isn’t the latest pill from a pharmaceutical company, but a genetic variant that some people have.

The PCSK9 gene codes for an enzyme that is important in controlling the amount of cholesterol in the bloodstream.  Some people carry a genetic variant in the PCSK9 gene that decreases their cholesterol levels. This is also associated with a decreased risk of heart disease!

Members: See your data below

Log in and select your data file Not a member? Join now.

Check your genetic data for rs11591147 R46L (23andMe v4, v5):

  • G/G: normal
  • G/T: decreased LDL-cholesterol, 30% lower risk of heart disease[ref] [ref]
  • T/T: decreased LDL-cholesterol, > 30% lower risk of heart disease

Members: Your genotype for rs11591147 is .

Want to learn more about other PCSK9 genetic variants? Check out the full article on PCSK9. 

 

*SNP stands for Single Nucleotide Polymorphism, which is when one of the nucleotide bases (the A, C, G, or Ts) is replaced by a different nucleotide base in a gene. 

Want more quick bits about your genes? Read through all the Snips about SNPs



Author Information:   Debbie Moon
Debbie Moon is the founder of Genetic Lifehacks. She holds a Master of Science in Biological Sciences from Clemson University and an undergraduate degree in engineering. Debbie is a science communicator who is passionate about explaining evidence-based health information. Her goal with Genetic Lifehacks is to bridge the gap between the research hidden in scientific journals and everyone's ability to use that information. To contact Debbie, visit the contact page.