Snips about SNPs: Low LDL Cholesterol

Low LDL cholesterol throughout life and a decreased risk of heart disease? Sign me up! No, this isn’t the latest pill from a pharmaceutical company, but a genetic variant that some people have.

The PCSK9 gene codes for an enzyme that is important in controlling the amount of cholesterol in the bloodstream.  Some people carry a genetic variant in the PCSK9 gene that decreases their cholesterol levels. This is also associated with a decreased risk of heart disease!

Check your 23andMe data for rs11591147 R46L (v4, v5):

  • G/G: normal
  • G/T: decreased LDL-cholesterol, 30% lower risk of heart disease[ref] [ref]
  • T/T: decreased LDL-cholesterol, > 30% lower risk of heart disease

Want to learn more about other PCSK9 genetic variants? Check out the full article on PCSK9. 

 

*SNP stands for Single Nucleotide Polymorphism, which is when one of the nucleotide bases (the A, C, G, or Ts) is replaced by a different nucleotide base in a gene. 

Want more quick bits about your genes? Read through all the Snips about SNPs



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