Vitamin D and MS

The genetic connection between Vitamin D and MS

Many researchers have speculated that there must be a link between Vitamin D and multiple sclerosis (MS) based on the distribution of cases at certain latitudes. There are increased numbers of MS cases in areas that don’t get as much sunlight, and thus residents of those areas are more likely to have lower vitamin D levels.[ref][ref]

MS is an autoimmune disease that is thought to be caused partially by genetics and partially by environmental factors.  Genetically, susceptibility to multiple sclerosis has been linked to quite a few different genes that give a slight increase to the risk, but one that stands out as a strong risk factor is in the HLA family of genes.  The HLA genes code for the major histocompatibility complex (MHC) proteins that are an integral part of our immune system.

HLA-DRB1*1501 is a variant that is linked to a higher risk of MS, with studies estimating that people who are homozygous for HLA-DRB1*1501 have up to 6 times the normal risk for MS.

This ties into vitamin D levels because vitamin D regulates the expression of HLA-DRB1. From a 2009 study on the topic: “It was found that vitamin D specifically interacts with HLA-DRB1*1501 to influence its expression. This study therefore provides more direct support for the already strong epidemiological evidence implicating sunlight and vitamin D in the determination of MS risk, and implies that vitamin D supplementation at critical time periods may be key to disease prevention.” [ref]

If you have genetic data from someplace like 23andMe or AncestryDNA, HLA-DRB1*1501 type corresponds to rs3135388 – the A allele.[ref]

Check your 23andMe results for rs3135388 (v4, v5):

  •  AA: 6x increase in risk for MS, Vitamin D may help
  • AG: 3x increase in risk for MS, Vitamin D may help
  • GG: no increased risk for MS

 

My take away:  If you are at an increased risk for MS due to the HLA-DRB1*1501 haplotype, you may want to get your Vitamin D levels checked.  Read more from the Vitamin D Council on how to get your daily D.  Note that there are 15 other SNPs also thought to be associated in some way with Multiple Sclerosis.

More information:

Categories: Vitamins & Minerals

3 Comments

Jessica Behan · April 17, 2018 at 8:55 pm

Hi
Yes please could you tell me what G/G refers to. Thanks

    Debbie Moon · April 18, 2018 at 1:38 pm

    Hi Jessica –
    Thanks for asking the question about GG. The results from 23andMe are always given on the forward strand of DNA, while for this study, the results were given on the reverse strand. In DNA, the bases always pair together in a specific way: C pairs with G, and T pairs with A. So for any study that gives the results in for the reverse strand, you can ‘translate’ it to the 23andMe orientation with C=G and A=T.
    So that was the long explanation… I do appreciate you asking the question! I’ve gone back and changed the article to match up with 23andMe orientation so that everyone else isn’t confused as well.

Jeanne · June 29, 2018 at 3:11 pm

This information truly resonates with me. A Promethease analysis of my 23andme raw data showed about 5 different autoimmune genes that predispose me to MS, Lupus, Graves, rheumatoid arthritis, Parkinson’s, ad nauseum. What is frustrating is that I also have a double set of mutant genes (VDR-TAQ) which make it very hard for my body to synthesize and utilize vitamin D! Any vitamin supplement with vitamin D can be problematic because : what would be a helpful dosage amount for a normal person would/does give me peripheral neuropathy. I have done trial and error with vitamin D supplements over the past 7 years. ( Even dairy products that are D3 fortified give me problems).
The result is: get my D3 from sunshine. That kind of D does not give me peripheral neuropathy. Good thing I live in Arizona!

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