Weight Loss & Your Genes

Wondering what your 23 and Me data indicates about your genetic susceptibility to gain weight?  I’ve dug into the research to see which genes are associated with obesity — along with specific life hacks that take into account your genetic variants.

We don’t all have the same genetic variants that cause weight gain. Thus, you need to optimize your weight loss plan for the genetic variants that you carry.

No snake-oil, no quick fixes – just science that you can apply to fit your genes

Start here:


Recent articles on Weight Loss and Your Genes:

SIRTfoods diet: Sirtuins and turning on your skinny genes - The SIRTfood diet, made popular by Adele's recent weight loss, theoretically works by affecting your sirtuin gene expression. Learn about your SIRT genes and you genetic variants.
PPAR-Delta: Burning off the Fat - Can you increase your metabolic rate  – even when resting – through eating a high-fat diet? Likewise, will exercise kick ...

Read morePPAR-Delta: Burning off the Fat

DIY Genetic Weight Loss Report - Do your genes play a role in how much you weigh? Absolutely! But before you get all excited about blaming ...

Read moreDIY Genetic Weight Loss Report

Detoxifying Phthalates:  Genes and Diet - Plastics are everywhere – and a source of the chemicals that we are exposed to on a daily basis.  One ...

Read moreDetoxifying Phthalates:  Genes and Diet

Hacking your endocannabinoids for weight loss - What drives us to eat? We spend a lot of time working to make money to buy food, prepare food, ...

Read moreHacking your endocannabinoids for weight loss

Hacking your endocannabinoid system for weight loss - What drives us to eat? We spend a lot of time working to make money to buy food, prepare food, ...

Read moreHacking your endocannabinoid system for weight loss

A Sweet Tooth Without Weight Gain: FGF21 Gene - A new study recently published in the journal Cell shows a genetic link to having a sweet tooth, but this ...

Read moreA Sweet Tooth Without Weight Gain: FGF21 Gene

Leptin Receptors: Genetics and Hunger - Do you wonder why other people don't seem to struggle with wanting to eat more? Ever wished your body could ...

Read moreLeptin Receptors: Genetics and Hunger

Digesting Carbohydrates: Amylase variants - Carbohydrate digestion begins in the mouth with an enzyme called amylase.  Saliva mixes with your food as you chew it, ...

Read moreDigesting Carbohydrates: Amylase variants

Weight Loss Genetics: Ghrelin - Your weight is controlled, in part, by your brain. There is a complex feedback system that lets your brain know ...

Read moreWeight Loss Genetics: Ghrelin

Turning up the internal heat for weight loss- UCP1 genetic variants - The dream for overweight people: just turn up the internal heat and naturally burn off the extra fat.It turns out that genetically some people do have more active 'internal heat' and they actually are burning off more energy all the time.
BPA: How Your Genes Influence BPA Detoxification - BPA, a chemical found in some plastics, has been linked to a variety of effects on people including obesity, insulin ...

Read moreBPA: How Your Genes Influence BPA Detoxification

Early to bed, early to rise – helps with weight loss and diabetes - Meal timing and light at night are modern issues that impact diabetes and obesity risk.
Circadian Rhythm: Weight Loss and Meal Timing - It isn't just what you eat, it is WHEN you eat. Learn how meal timing impact weight - and how your genes are important here.
Growing up ‘big boned’: MC4R gene and obesity - There are several key players in our body's regulation of hunger, satiety, and energy expenditure. Two pivotal hormones involved appetite ...

Read moreGrowing up ‘big boned’: MC4R gene and obesity

Hacking BDNF for weight loss - Brain-derived neurotrophic factor (BDNF) is a fascinating growth hormone that performs many functions in our brain. Its involvement helps to support neurons and neuronal growth. In addition, it plays a role in long-term memory — and it also is important in obesity.
Weight Loss: Optimizing your diet based on your genes - Diet gurus, talking heads on TV, government food pyramids, and your friend who lost 20 pounds… What do they all ...

Read moreWeight Loss: Optimizing your diet based on your genes

How our genes shape our gut microbiome and our weight - Several studies have come out recently showing that those who are overweight have a different gut microbiome composition than those ...

Read moreHow our genes shape our gut microbiome and our weight

Emulsifiers in Processed Foods: Your genes and your microbiome - Our genes and our environment both contribute to our gut microbiome, allowing some species to flourish and keeping others away. ...

Read moreEmulsifiers in Processed Foods: Your genes and your microbiome

DHEA and Your Weight - DHEA is a hormone that does a lot in the body - including influencing muscle mass and weight. This quick ...

Read moreDHEA and Your Weight

FTO: The ‘fatso’ gene & weight loss options - Research shows that about 60% of obesity susceptibility is due to genetic differences, and the FTO gene is one of ...

Read moreFTO: The ‘fatso’ gene & weight loss options

UCP2 Gene: Weight Loss Lifehacks - Turning up the heat on your metabolism is the job of UCP2. The UCP2 gene codes for an uncoupling protein ...

Read moreUCP2 Gene: Weight Loss Lifehacks

Weight Loss Genetics – MC4R Revisited - I was catching up on podcasts this weekend and listened to a fascinating one by Dr. Rhonda Patrick.  She does ...

Read moreWeight Loss Genetics – MC4R Revisited

Weight loss genetics – GNB3 C825T - There are lots of different genetic variants that add a little bit to your risk of being overweight. These genetic ...

Read moreWeight loss genetics – GNB3 C825T

Getting to the root cause – Obesity Virus? - When looking at the obesity epidemic around the world, one thing becomes clear: it is complicated!   For years we ...

Read moreGetting to the root cause – Obesity Virus?