Weight Loss & Your Genes

Wondering what your 23 and Me data indicates about your genetic susceptibility to gain weight?  I’ve dug into the research to see which genes are associated with obesity — along with specific life hacks that take into account your genetic variants.

We don’t all have the same genetic variants that cause weight gain. Thus, you need to optimize your weight loss plan for the genetic variants that you carry.

No snake-oil, no quick fixes – just science that you can apply to fit your genes

Start here:


Recent articles on Weight Loss and Your Genes:

Detoxifying Phthalates:  Genes and Diet - Plastics are everywhere – and a source of the chemicals that we are exposed to on a daily basis.  One ... Read more
Hacking your endocannabinoids for weight loss - What drives us to eat? We spend a lot of time working to make money to buy food, prepare food, ... Read more
Hacking your endocannabinoid system for weight loss - What drives us to eat? We spend a lot of time working to make money to buy food, prepare food, ... Read more
Turning up the internal heat for weight loss- UCP1 genetic variants - The dream for overweight people: just turn up the internal heat and naturally burn off the extra fat.It turns out that genetically some people do have more active 'internal heat' and they actually are burning off more energy all the time.
BPA: How Your Genes Influence BPA Detoxification - BPA, a chemical found in some plastics, has been linked to a variety of effects on people including obesity, insulin ... Read more
Early to bed, early to rise – helps with weight loss and diabetes - Meal timing and light at night are modern issues that impact diabetes and obesity risk.
Circadian Rhythm: Weight Loss and Meal Timing - There are five key elements to weight loss from a circadian point of view: Timing of Meals; Light Exposure; Sleep; ... Read more
Hacking BDNF for weight loss - Brain-derived neurotrophic factor (BDNF) is a fascinating growth hormone that performs many functions in our brain. Its involvement helps to ... Read more
Weight Loss: Optimizing your diet based on your genes - Diet gurus, talking heads on TV, government food pyramids, and your friend who lost 20 pounds… What do they all ... Read more
Circadian Rhythms: Genes at the Core of Our Internal Clocks - Circadian rhythms are the natural biological rhythms that shape our biology.  Most people know about the master clock in our ... Read more
Digesting Carbohydrates: Amylase variants - Carbohydrate digestion begins in the mouth with an enzyme called amylase.  Saliva mixes with your food as you chew it, ... Read more
How our genes shape our gut microbiome and our weight - Several studies have come out recently showing that those who are overweight have a different gut microbiome composition than those ... Read more
Emulsifiers in Processed Foods: Your genes and your microbiome - Our genes and our environment both contribute to our gut microbiome, allowing some species to flourish and keeping others away. ... Read more
Adiponectin levels, food choices, and genetics - Adiponectin, a hormone discovered in the 1990’s, is secreted by adipose (fat) tissue.  It is an anti-inflammatory protein, protective against the effects ... Read more
Weight Loss Genetics – DHEA - Dehydroepiandrosterone (DHEA) is one of our body’s most abundantly produced steroid hormones. It is secreted by the adrenal glands, gonads, ... Read more
Weight Loss Genetics – PLIN1 - The perilipin 1 gene codes for the protein that covers lipid droplets in fat cells.  This coating protects the lipid droplets ... Read more
PPARG: A genetic variant that can protect against obesity and type-2 diabetes, but only if you eat the right diet. - The PPARG (peroxisome proliferator-activated receptor-gamma) gene has been associated with obesity, metabolic syndrome, and risk for type-2 diabetes. This gene ... Read more
FTO: The ‘fatso’ gene & weight loss options - Research shows that about 60% of obesity susceptibility is due to genetic differences, and the FTO gene is one of ... Read more
UCP2 Gene: Weight Loss Lifehacks - Turning up the heat on your metabolism is the job of UCP2. The UCP2 gene codes for an uncoupling protein ... Read more
Weight Loss Genetics – MC4R Revisited - I was catching up on podcasts this weekend and listened to a fascinating one by Dr. Rhonda Patrick.  She does ... Read more
Weight loss genetics – GNB3 C825T - There are lots of different genetic variants that add a little bit to your risk of being overweight. These genetic ... Read more
Weight Loss Genetics – Obesity Virus? - When looking at the obesity epidemic around the world, one thing becomes clear: it is complicated!  For years we have ... Read more
Adiponectin levels, glucose regulation, and your genes - Adiponectin, a hormone secreted from adipose (fat) tissue, is involved in glucose regulation.  Studies show that low levels of adiponectin ... Read more