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Glyphosate: Interaction with Genetics

RoundUp is the most widely used herbicide in the world. It is made by Monsanto, which is now owned by Bayer. Glyphosate is the active ingredient in RoundUp, and it will kill most broadleaf plants and grasses. [ref] Glyphosate works by blocking the shikimate…

genetic variants 23andme TNF alpha

TNF-alpha: Inflammation Genes

Do you feel like you are always dealing with inflammation? Joint pain, food sensitivity, etc? Perhaps you are genetically geared towards a higher inflammatory response. Tumor necrosis factor (TNF) is an inflammatory cytokine that acts as a signaling molecule in our immune system. In…

Sore muscles after workouts? Could be AMPD1 deficiency.

Do you end up getting sore after pretty much every work out at the gym? It could be that a deficiency caused by the AMPD1 genetic variant is the cause. (Or you could be over-doing it :-) Adenosine Monophosphate deaminase is an enzyme coded…

Living to 100: Longevity and Genetics

There are several genes known as “longevity” genes that increase your odds of becoming a centenarian. Specific variants of these genes are associated with an increased likelihood of living to be 100 or more. And…  more importantly, these genetic variants are linked to longer…

Snips about SNPs: Low LDL Cholesterol

Low LDL cholesterol throughout life and a decreased risk of heart disease? Sign me up! No, this isn’t the latest pill from a pharmaceutical company, but a genetic variant that some people have. The PCSK9 gene codes for an enzyme that is important in…

Tryptophan: Building serotonin and melatonin

For a lot of people, tryptophan brings to mind napping on the couch after eating a huge amount of Thanksgiving turkey. (Turns out that it isn’t really true that the tryptophan in turkey makes you sleepy – but the post Thanksgiving dinner nap phenomenon…

Snips about SNPs: Taste Receptors

Do you love dark chocolate and coffee? Both of them have bitter flavors that some people can taste – and some people cannot!  We have a bunch of different genes that code for different taste receptors. So different genetic variants of those taste receptor…

Snips about SNPs: High Triglycerides and APOA5

The APOA5 gene codes for a lipoprotein that is important in triglyceride metabolism. A variant in the APOA5 gene is linked to higher triglyceride levels and also an increased risk of heart disease.  [ref] Check your genetic data for rs662799 (23andMe v4, v5; AncestryDNA): A/A: normal…

Snips about SNPs: MTHFR

The MTHFR gene codes for the enzyme that converts folate into the form that your body needs in the methylation cycle (methylfolate).  There are two main SNPs that have been shown to decrease the efficiency of the MTHFR enzyme.  For both of these, it…

Snips about SNPs: Opioid Receptor

Your body’s reaction to opiates, such as oxycodone or hydrocodone, depends on the opioid receptor.  Genetic variants in OPRM1 (opioid receptor, mu 1) change your response to opioids. This can mean more pain, which leads to increased dosages… And this can lead to a…