Find out how YOUR genes interact with supplements. Understanding your genetic variants (SNPs):
- Can help you narrow down the supplements more likely to work for YOU.
- Helps sort out the supplements that aren’t likely to have a large benefit.
- Give you a heads up about supplements likely to cause you side effects.
This is just an overview.
Be sure to click through to the full article for supplements you’re interested in. The full article includes clinical trials, safety data, quality testing of supplement brands, and full references.
Jump to: Ashwagandha, Luteolin, Curcumin, Berberine, Quercetin, Hesperidin, Nattokinase, CoQ10, Nicotinamide Riboside, Creatine
Full article on ashwagandha research studies.
| Key Benefits | Who May Benefit | Who Should Use Caution |
|---|---|---|
| – Stress and anxiety relief – Muscle gains, increase T – Subclinical hypothyroidism – Cognitive function, focus, mood – Improved sleep quality – Sexual function (women) |
– Individuals with HPA axis/cortisol dysfunction – High anxiety/stress with certain genotypes – Men seeking to boost testosterone levels |
– People with BChE mutations (possible nightshade-family issues) |
Ashwagandha may be beneficial for these highlighted variants:
Cortisol and HPA axis dysfunction:
Research shows ashwagandha effectively regulates cortisol levels in people with HPA axis dysfunction. Genetic variants can increase susceptibility to issues with the HPA (hypothalamus – pituitary – adrenal) axis, including altered cortisol rhythm. (Please read the full article for details):
| Gene | RS ID | Your Genotype | Effect Allele | Effect Allele Frequency | Notes About Effect Allele |
|---|---|---|---|---|---|
| NR3C1 | rs6189 | -- | T | 0.02 | Glucocorticoid receptor mutation linked to cortisol resistance |
| NR3C1 | rs6190 | -- | T | 0.022 | Glucocorticoid receptor mutation linked to cortisol resistance |
| NR3C1 | rs6198 | -- | C | 0.16 | Glucocorticoid receptor mutation linked to cortisol resistance |
| NR3C1 | rs56149945 | -- | C | 0.02 | Increased sensitivity to glucocorticoids;increased risk of obesity; hypertension |
| NR3C1 | rs41423247 | -- | C | 0.33 | Hypersensitivity to glucocorticoids |
| NR3C1 | rs6191 | -- | A | 0.37 | GR variant linked to some resistance to cortisol (minor) |
| NR3C1 | rs10052957 | -- | A | 0.3 | Linked to hypersensitivity to cortisol (minor) |
| NR3C2 | rs5522 | -- | C | 0.11 | Associated with resistance to cortisol; depression. |
| CRHR1 | rs110402 | -- | G | 0.55 | Elevated adult cortisol if exposed to childhood trauma; increased risk of depression or anxiety |
| CRHR1 | rs242924 | -- | G | 0.54 | Elevated adult cortisol if exposed to childhood trauma; increased risk of depression or anxiety |
| CRHR1 | rs242941 | -- | A | 0.34 | Increased risk of depression |
| CRHR1 | rs242939 | -- | C | 0.07 | Increased risk of depression |
| FKBP5 | rs1360780 | -- | T | 0.31 | Incomplete cortisol recovery; risk of depression; anxiety |
| FKBP5 | rs3800373 | -- | C | 0.28 | Incomplete cortisol recovery; risk of depression; anxiety |
| MC2R | rs1941088 | -- | A | 0.36 | low cortisol response |
| MC2R | rs28940892 | -- | C | 0.00003 | Mutation linked to ACTH resistance (important) |
| SERPINA6 | rs11621961 | -- | T | 0.34 | Less cortisol binding globulin; lower plasma cortisol |
| SERPINA6 | rs941601 | -- | T | 0.14 | Less cortisol binding globulin; lower plasma cortisol |
| NR3C1 | i4990006 | -- | C | 0.02 | Increased sensitivity to glucocorticoids;increased risk of obesity; hypertension |
Genetics and Anxiety:
Ashwagandha has many studies on it showing that it may help with anxiety if it is due to stress and high cortisol. One study tested 300 mg, 2x a day vs. placebo. After 8 weeks, cortisol was reduced by an average of 22%, which is significant.[ref] (Please read the full article for details):
| Gene | RS ID | Your Genotype | Effect Allele | Effect Allele Frequency | Notes About Effect Allele |
|---|---|---|---|---|---|
| ADORA2A | rs5751876 | -- | T | 0.42 | TT: Increased risk panic disorder; Increased anxiety with high caffeine |
| OXTR | rs53576 | -- | A | 0.32 | less empathetic, less sensitive to social rejection (more resilient); G/G: increased separation anxiety risk |
| GNB3 | rs5443 | -- | T | 0.33 | When combined with OXTR rs5443 GG - Increased separation anxiety |
| SLC6A4 | rs140701 | -- | T | 0.43 | Increased risk panic disorder; social anxiety disorder |
| BDNF | rs6265 | -- | T | 0.18 | Decreased BDNF; Increased risk anxiety disorders |
| FKBP5 | rs1360780 | -- | T | 0.31 | TT only: incomplete cortisol recovery; Increased anxiety after psychosocial stress |
| CHCR1 | rs110402 | -- | G | 0.55 | Increased cortisol in childhood trauma |
| ACCN2 | rs10875995 | -- | C | 0.31 | Heightened reactivity to high CO2 levels; Increased risk panic disorders |
| ACCN2 | rs685012 | -- | C | 0.36 | Heightened reactivity to high CO2 levels; Increased risk panic disorders |
Testosterone:
Ashwagandha increases testosterone levels in men who are weight-lifting or doing resistance training. One study showed an average increase in testosterone of about 15%.[ref] In another eight-week placebo-controlled trial of ashwagandha, 300 mg ashwagandha root extract 2x/day increased muscle strength, arm size, and more than tripled testosterone levels.[ref] (Please read the full article for details):
| Gene | RS ID | Your Genotype | Effect Allele | Effect Allele Frequency | Notes About Effect Allele |
|---|---|---|---|---|---|
| SHBG | rs12150660 | -- | G | 0.78 | Lower free testosterone |
| SHBG | rs6258 | -- | T | 0.006 | Lower free testosterone |
| SHBG | rs6259 | -- | A | 0.1 | Higher SHBG levels |
| SHBG | rs1799941 | -- | A | 0.23 | Higher SHBG levels |
| FAM9B | rs5934505 | -- | T | 0.72 | Lower free testosterone |
| LIN28B | rs7759938 | -- | C | 0.32 | Lower free testosterone |
| FSHB | rs10835638 | -- | T | 0.06 | Lower free testosterone |
| SHBG | rs727428 | -- | T | 0.43 | lower SHBG levels, higher DHT levels |
Cautions with Ashwagandha:
BChE and Nightshades:
Ashwagandha is a plant in the nightshade family. People with BChE severe mutations (A variant, F variants below) may need to be cautious with nightshades.
| Gene | RS ID | Your Genotype | Effect Allele | Effect Allele Frequency | Notes About Effect Allele |
|---|---|---|---|---|---|
| BChE | rs1803274 | -- | T | 0.19 | K-variant; Decreased BChE; possible problems w/ organophosphates and nightshades |
| BChE | rs1799807 | -- | C | 0.01 | A-variant; possibly delayed recovery from succinylcholine (anesthesia) (important) |
| BChE | rs28933389 | -- | A | 0.0008 | F1-variant; possibly delayed recovery from succinylcholine (anesthesia) (important) |
| BChE | rs28933390 | -- | A | 0.005 | F2-variant; possibly delayed recovery from succinylcholine (anesthesia) (important) |
| BChE | rs2668207 | -- | C | 0.04 | Minor decrease in BChE levels |
| BChE | rs1126680 | -- | T | 0.07 | Decreased BChE; Increased risk of hyperhidrosis combined with K-variant |
Additional Articles that reference Ashwagandha:
- Leptin: Ashwagandha, an adaptogenic Ayurvedic herb, appears to be a leptin sensitizer.
- Thyroid: A randomized, double-blind, placebo-controlled trial in adults with hypothyroidism found that ashwagandha reduced serum TSH levels.[ref]
- Male infertility: Ashwagandha increases sperm count, volume, and motility.[ref]
- Sleep report: For sleep issues due to stress, ashwagandha may help.[ref][ref]
Luteolin research studies – full article here
Luteolin is a flavonoid found in abundance in broccoli, parsley, and celery.
| Key Benefits | Who May Benefit | Who Should Use Caution |
|---|---|---|
| – Anti-inflammatory (TNF inhibitor) – Mast cell stabilizer – Neuroprotective, reduces brain fog – Improves intestinal barrier integrity – Improves sleep, reduces histamine |
– Individuals with brain fog that is due to inflammation – Inflammation due to TNF-alpha – People with histamine intolerance or MCAS |
– People with slow COMT function, especially if stacking with methyl donors |
Luteolin may work well for these highlighted variants:
Brain Fog from Inflammation:
While there are multiple causes of brain fog, luteolin may be a good option for anyone with inflammation-related cognitive dysfunction. (Please read the full article for details):
| Gene | RS ID | Your Genotype | Effect Allele | Effect Allele Frequency | Notes About Effect Allele |
|---|---|---|---|---|---|
| TNF | rs1800629 | -- | A | 0.15 | Higher TNF levels, increased risk of many chronic inflammatory conditions |
| TNF | rs361525 | -- | A | 0.05 | Higher TNF levels, increased risk of many chronic inflammatory conditions |
| IL8 | rs4073 | -- | A | 0.5 | A/A: Increased IL8; increased risk of periodontitis, gastritis, Alzheimers, diabetic nephropathy |
| IL6 | rs1800795 | -- | C | 0.34 | C/C: lower risk of gingivitis |
| IL1B | rs16944 | -- | G | 0.63 | G - Typical risk of septic shock; A/A: Increased risk of septic shock |
| IL1B | rs1143634 | -- | A | 0.22 | Increased risk of gingivitis |
| IL1A | rs1800587 | -- | A | 0.28 | Increased IL1A, increased risk of gum disease, tinnitus, acne, hearing loss |
| IL10 | rs1800896 | -- | C | 0.45 | CC: higher IL-10 (usually good!) |
| NLRP3 | rs35829419 | -- | A | 0.03 | Increased susceptibility to several chronic inflammatory diseases. |
| HMGB1 | rs1045411 | -- | T | 0.23 | increased sepsis risk, higher HMGB1 levels in infection; |
| INFG | rs2430561 | -- | A | 0.39 | increased inflammatory and sickness behavior |
| MTHFR | rs1801133 | -- | A | 0.33 | Decreased methyl group production, decreased detoxification of mercury and arsenic, possibly decreased melatonin production |
| GSTM1 | rs366631 | -- | A | 0.78 | AA: GSTM1 null, increased risk of cancer, increased negative effects of smoking |
| GSTO1 | rs4925 | -- | A | 0.3 | Decreased detoxification of arsenic; increased risk of PCOS |
| GSTA1 | rs3957357 | -- | A | 0.38 | Decreased detoxification, increased risk of depression, |
| NFE2L2 | rs6721961 | -- | T | 0.11 | Decreased Nrf2, increased risk of male infertility, increased risk of CVD, |
| AS3MT | rs11191439 | -- | C | 0.1 | Arsenic is more harmful |
| NQO1 | rs1800566 | -- | A | 0.2 | Increased risk of cancer from benzene and smoking, increased risk of Parkinson’s from pesticide exposure |
| SOD1 | rs1041740 | -- | T | 0.3 | Increased ROS, increased risk of kidney problems, heart disease |
| SOD2 | rs5746136 | -- | T | 0.28 | Increased ROS, increased risk of asthma, PCOS |
Inflammation and TNF alpha:
Luteolin supplementation has been shown to decrease TNF levels in clinical trials.
([ref]Please read the full article for details):
| Gene | RS ID | Your Genotype | Effect Allele | Effect Allele Frequency | Notes About Effect Allele |
|---|---|---|---|---|---|
| TNF | rs1800629 | -- | A | 0.15 | Increased TNF alpha, increased risk of many chronic inflammatory diseases |
| TNF | rs361525 | -- | A | 0.05 | Increased TNF alpha, increased risk of many chronic inflammatory diseases |
| TNF | rs1799964 | -- | C | 0.21 | Increased TNF alpha, increased risk of many chronic inflammatory diseases |
| TNF | rs1799724 | -- | T | 0.12 | Increased TNF alpha, increased risk of many chronic inflammatory diseases |
| TNFRSF1A | rs1800693 | -- | C | 0.39 | Increased risk of multiple sclerosis; increased NF-kB signaling |
| TNFRSF1A | rs767455 | -- | C | 0.42 | Increased risk of inflammatory diseases. |
| TNFRSF1B | rs1061622 | -- | G | 0.23 | Increased risk of psoriasis, lupus |
| TNF | rs1800610 | -- | A | 0.08 | Lower TNF; less inflammation but more susceptible to infectious diseases |
Histamine intolerance:
Studies have shown Luteolin to inhibit histamine release from mast cells.[ref](Please read the full histamine intolerance article for details):
| Gene | RS ID | Your Genotype | Effect Allele | Effect Allele Frequency | Notes About Effect Allele |
|---|---|---|---|---|---|
| AOC1 | rs10156191 | -- | T | 0.26 | Reduced production of DAO |
| AOC1 | rs2052129 | -- | T | 0.23 | Reduced production of DAO |
| AOC1 | rs1049742 | -- | T | 0.07 | Reduced production of DAO |
| AOC1 | rs1049793 | -- | G | 0.31 | Reduced production of DAO |
| AOC1 | rs2071514 | -- | A | 0.19 | possibly slightly higher DAO |
| HMNT | rs1050891 | -- | A | 0.79 | Reduced breakdown of serum histamine |
| HMNT | i3000469 | -- | T | 0.1 | Reduced breakdown of serum histamine |
| HMNT | rs2071048 | -- | T | 0.58 | T/T: Reduced breakdown of serum histamine (common) |
| HMNT | rs11558538 | -- | T | 0.1 | Reduced breakdown of serum histamine |
| HDC | rs2073440 | -- | G | 0.02 | Decreased histamine production |
| HDC | rs267606861 | -- | A | 0 | rare pathogenic mutation, linked to Tourettes |
| HRH1 | rs901865 | -- | T | 0.17 | Increased H1 receptor, increased asthma risk |
| HRH2 | rs2067474 | -- | A | 0.04 | Decreased H2 receptor |
| HRH4 | rs11662595 | -- | G | 0.09 | decreased HRH4 activation (receptor dysfunction), increased risk of progression in non-small cell lung cancer |
| MTHFR | rs1801133 | -- | A | 0.33 | MTHFR C677T, decreased enzyme function, affects methylation cycle |
| MTHFR | rs1801131 | -- | G | 0.3 | MTHFR A1298C, slightly decreased enzyme function, slightly affects methylation cycle |
Cautions with Luteolin:
COMT interaction:
Luteolin is metabolized using the COMT enzyme, so individuals with slow COMT may want to use with caution and watch for mood changes. This may be more important if taking more than one supplement that utilizes COMT (or at high doses).
| Gene | RS ID | Your Genotype | Effect Allele | Effect Allele Frequency | Notes About Effect Allele |
|---|---|---|---|---|---|
| COMT | rs4680 | -- | A | 0.48 | GG = higher activity; AG=Intermediate activity AA = lower activity |
| COMT | rs4633 | -- | T | 0.48 | CC = higher activity ; TT = lower COMT activity |
| COMT | rs6267 | -- | T | 0.003 | Minor decrease in COMT |
| COMT | rs165599 | -- | A | 0.64 | Minor decrease in COMT |
| COMT | rs165774 | -- | A | 0.29 | lower COMT activity; more likely to have irrational beliefs if subjected to maltreatment in childhood |
More articles that reference luteolin:
- Long Covid: Supplemental luteolin or quercetin can block the inflammasome production initiated by activating the toll-like receptors. The researcher suggests combining luteolin, quercetin, and olive oil (for absorption and additional antiviral properties).[ref]
- NAFLD (fatty liver): Luteolin protects against fatty liver by improving intestinal barrier integrity. It also increases microbial diversity in the gut, according to animal studies.[ref]
- Chronic Lyme: A study looked at baicalein and luteolin, combined with either iodine or rosmarinic acid, and found that they may be effective against the typical spirochaete form and persistent forms as well.[ref]
Get the full details on curcumin here.
Curcumin, a polyphenol found in turmeric, is a spice used in traditional Indian cuisine and other areas of Asia. It has a long history of use as a spice and in traditional Ayurvedic medicine.
| Key Benefits | Who May Benefit | Who Should Use Caution |
|---|---|---|
| – Anti-inflammatory – Improving depression (if depression is due to inflammation) – Decreasing joint pain in arthritis – Improves cognitive function in middle age – Improves liver markers in NAFLD |
– Individuals with depression that is due to inflammation – Detoxification of mold and mycotoxins – People with chronic migraines |
– People with variants related to oxalates or kidney stones |
Curcumin may work well for:
Mold detoxification:
Curcumin increases the UGT enzymes and upregulates the glucuronidation pathway, essential for mycotoxin elimination.[ref]
| Gene | RS ID | Your Genotype | Effect Allele | Effect Allele Frequency | Notes About Effect Allele |
|---|---|---|---|---|---|
| XPC | rs2228001 | -- | G | 0.4 | Increased relative risk of liver cancer with aflatoxin B1 exposure |
| CYP1A2 | rs12720461 | -- | T | 0.002 | Decreased CYP1A2 enzyme activity, which may impact detoxification of aflatoxin B1 |
| CYP1A2 | rs72547517 | -- | A | 0 | Decreased CYP1A2 enzyme activity, which may impact detoxification of aflatoxin B1 |
| CYP1A2 | rs72547515 | -- | A | 0.00004 | Decreased CYP1A2 enzyme activity, which may impact detoxification of aflatoxin B1 |
| CYP3A4 | rs4987161 | -- | G | 0.00006 | CYP3A4*17, decreased function of enzyme; involved in phase I detoxification of aflatoxin G1 |
| CYP3A4 | rs4986909 | -- | A | 0.0001 | CYP3A4*13, decreased function of enzyme; involved in phase I detoxification of aflatoxin G1 |
| CYP3A4 | rs2740574 | -- | C | 0.11 | CYP3A4*1B, decreased function of enzyme; involved in phase I detoxification of aflatoxin G1 |
| CYP3A4 | rs4986910 | -- | G | 0.006 | CYP3A4*3, decreased function of enzyme; involved in phase I detoxification of aflatoxin G1 |
| CYP3A4 | rs4986907 | -- | T | 0.002 | CYP3A4*15A, decreased function of enzyme; involved in phase I detoxification of aflatoxin G1 |
| GSTM1 | rs366631 | -- | A | 0.78 | A/A: deletion (null) GSTM1 gene; increased risk of liver cancer with aflatoxin B1 exposure |
| GSTA1 | rs3957357 | -- | A | 0.38 | GSTA1*B, low/ non-functioning enzyme; increased risk of kidney disease with ochratoxin A exposure |
| GSTP1 | rs1695 | -- | G | 0.32 | G/G: reduced function, increased risk of liver damage with aflatoxin B1 exposure |
| SLCO1B1 | rs4149056 | -- | C | 0.14 | Increased risk of liver damage with aflatoxin B1 exposure |
| ADRA1A | rs1048101 | -- | G | 0.48 | G/G: This genotype may have fewer problems with reactions to patulin (theoretical); A/G and A/A: typical |
| GSDMB | rs7216389 | -- | T | 0.53 | increased risk of childhood asthma; 3-fold increased risk of asthma with known mold exposure |
| IL13 | rs20541 | -- | A | 0.2 | higher IgE levels; increased risk of allergic bronchopulmonary aspergillosis (fungal infection of the lung); increased risk of allergies, COPD |
Migraines:
Curcumin has been shown to reduce inflammatory cytokines in the brain, including TNF-alpha. A clinical trial found that the combo of curcumin and CoQ10 effectively reduced the number of migraines.[ref][ref](see full article on Migraines):
| Gene | RS ID | Your Genotype | Effect Allele | Effect Allele Frequency | Notes About Effect Allele |
|---|---|---|---|---|---|
| TRPM8 | rs10166942 | -- | C | 0.23 | decreased risk of migraines (temperature and menthol receptor gene) |
| BDNF | rs6265 | -- | T | 0.18 | Increased risk of migraines due to lower BDNF |
| MMP16 | rs10504861 | -- | T | 0.21 | Reduced risk of migraines |
| NNMT | rs694539 | -- | T | 0.18 | TT only: 4-fold increase in migraine risk (methylation cycle) |
| MTHFR | rs1801133 | -- | A | 0.33 | Increased risk of migraines (methylation cycle) |
| C7orf10 | rs4379368 | -- | T | 0.11 | Decreased risk of migraines (serotonin) |
| SLC6A4 | rs2066713 | -- | A | 0.37 | Decreased risk of migraines (serotonin) |
| AOC1 | rs1049793 | -- | G | 0.31 | Increased risk of migraines (histamines from foods) |
| AOC1 | rs10156191 | -- | T | 0.26 | Increased risk of migraines (histamines from foods) |
| TNF | rs3093664 | -- | G | 0.07 | Increased risk of migraines (inflammatory pathway) |
| TNF | rs1800750 | -- | A | 0.01 | Increased risk of migraines (inflammatory pathway) |
| TNF | rs1800629 | -- | A | 0.15 | Increased risk of migraines (inflammatory pathway) |
| IL1A | rs17561 | -- | A | 0.28 | Increased risk of migraines (inflammatory pathway) |
| KCNK18 | rs869025175 | -- | D | 0.0003 | rare mutation (talk with your doctor) |
| MTDH | rs1835740 | -- | T | 0.24 | This variant is linked to glutamate regulation. Glutamate is an excitatory neurotransmitter. |
| LRP1 | rs11172113 | -- | C | 0.39 | Less likely to have migraines caused by cholesterol |
| NRP1 | rs2506142 | -- | G | 0.19 | 2-fold increased risk of menstrual migraine |
| PHACTR1 | rs9349379 | -- | A | 0.61 | Increased risk of migraines |
| TRPV1 | rs8065080 | -- | C | 0.37 | C/T: more likely to have chronic migraines; C/C: protective against chronic migraines |
Depression and Inflammation:
A randomized clinical trial showed curcumin (500 mg/2x per day) to be more effective than a placebo for improving depression.[ref]
| Gene | RS ID | Your Genotype | Effect Allele | Effect Allele Frequency | Notes About Effect Allele |
|---|---|---|---|---|---|
| TNF | rs1800629 | -- | A | 0.15 | Increased TNF-alpha |
| IL6 | rs1800796 | -- | G | 0.92 | GG only: Increased depression with inflammation |
| IL6 | rs1800795 | -- | C | 0.34 | CC only: Increased risk depression with stress |
| IL6 | rs1800797 | -- | A | 0.36 | Increased depression risk (Chinese pop.) |
| IL6R | rs4129267 | -- | C | 0.62 | CC only: Increased risk anxiety; depression |
| IL1B | rs16944 | -- | G | 0.63 | GG only: Increased risk depression |
| IDO1 | rs9657182 | -- | C | 0.41 | CC only: more likely to have depr. with inflammation |
| KMO | rs1053230 | -- | T | 0.2 | increased 3-OH-kynurenine, decreased risk of bipolar with psychosis (good) |
Cautions with curcumin:
Curcumin may increase oxalate excretion in the urine. People with genetic SNPs that increase susceptibility to kidney stones (or with a history of kidney stones) may want to consult their physician before starting curcumin.
Check your kidney stone variants.
| Gene | RS ID | Your Genotype | Effect Allele | Effect Allele Frequency | Notes About Effect Allele |
|---|---|---|---|---|---|
| CASR | rs1501899 | -- | A | 0.38 | Increased risk of kidney stones |
| UMOD | rs4293393 | -- | G | 0.18 | Increased risk of kidney stones |
| DGKH | rs4142110 | -- | T | 0.62 | Decreased risk of kidney stones |
| CLND14 | rs219780 | -- | T | 0.2 | Decreased risk of kidney stones |
| AGXT | rs34116584 | -- | T | 0.13 | Adds to hyperoxaluria risk; increased risk kidney stones |
| GRHPR | i5012629 | -- | D | 0 | Mutation for hyperoxaluria. (important) |
| GRHPR | i5012628 | -- | D | 0.0003 | Mutation for hyperoxaluria. (important) |
| GRHPR | rs180177309 | -- | D | 0 | Mutation for hyperoxaluria. (important) |
| GRHPR | rs80356708 | -- | D | 0.0003 | Mutation for hyperoxaluria. (important) |
| GOX1 | rs2235250 | -- | T | 0.05 | T/T: increased risk of oxalate kidney stones |
| AGTX | rs121908524 | -- | A | 0.00009 | carrier of a primary hyperoxaluria mutation |
| AGTX | i5012625 | -- | A | 0.00009 | carrier of a primary hyperoxaluria mutation |
| AGTX | rs121908527 | -- | A | 0.00003 | carrier of a primary hyperoxaluria mutation |
| AGTX | i5001077 | -- | A | 0.00003 | carrier of a primary hyperoxaluria mutation |
| SLC26A6 | rs13324142 | -- | T | 0.1 | 30% reduction in oxalate transport from the kidney, increased relative risk of kidney stones in people with high oxalate levels |
| AGXT | rs180177197 | -- | C | 0 | primary hyperoxaluria likely pathogenic mutation |
| AGXT | rs180177195 | -- | C | 0 | primary hyperoxaluria likely pathogenic mutation |
| AGXT | rs180177193 | -- | I | 0 | primary hyperoxaluria likely pathogenic mutation |
More articles that reference curcumin:
- Mercury detoxification: Curcumin increases the GLCM, the rate-limiting enzyme for glutathione production, which is important in mercury detoxification.[ref][ref]
- Fatigue: Curcumin inhibits TNF-alpha production.[ref]
- Diabetes and blood glucose genes: The curcumin-treated group had a decrease in HOMA-IR.[ref]
- PCOS genes: Curcumin decreased blood glucose levels as well as LDL cholesterol.[ref]
- Estrogen metabolism: Curcumin induces the expression of GSTP1 (glutathione S-transferase P1), which is important in estrogen metabolism.
- Boosting BDNF: Curcumin reverses the decrease in BDNF levels from chronic stress.[ref]
- Rheumatoid Arthritis: Curcumin is beneficial in reducing inflammation in RA.[ref]
- IL-17 and Autoimmune Risk: Curcumin was found to decrease IL-17 (in an animal study).[ref]
- HMGB1 and Inflammasome activation: In animal studies, Curcumin inhibits HMGB1 release.[ref][ref]
- Osteoarthritis: A natural TNF-alpha blocker, curcumin has been shown in several studies to be effective for osteoarthritis.[ref][ref] A clinical trial found that curcumin (500mg / 3x per day) was as effective as diclofenac for osteoarthritis – but with fewer side effects.[ref]
- MRGPRX2 receptor on Mast Cells: Curcumin is likely a MRGPRX2 receptor blocker (animal and cell studies).[ref]
Full article and details on berberine
Berberine is a natural supplement with some amazing research for reducing high blood glucose levels and high cholesterol. The drawback, though, is poor absorption in the intestines, decreasing its effectiveness.
| Key Benefits | Who May Benefit | Who Should Use Caution |
|---|---|---|
| – Lowers blood glucose – Improves LDL cholesterol and triglyceride levels – Helpful for NAFLD (fatty liver disease) – Improves intestinal barrier function – Beneficial for PCOS |
– Individuals with high LDL due to PCSK9 variants – People with high Lp(a) |
– People on prescription medications that utilize CYP3A4 and CYP2D6 (especially if combined with SNPs) -People with G6PD deficiency |
Berberine may work well for:
PCSK9 variant with high LDL cholesterol:
Berberine is a natural inhibitor of PCSK9 and has been shown in human studies[ref][ref] and cell studies[ref] to decrease cholesterol.For someone with variants that increase PCSK9 and increase cholesterol (below), berberine may be beneficial for lowering cholesterol. Talk to your doctor, of course, if you have questions.
| Gene | RS ID | Your Genotype | Effect Allele | Effect Allele Frequency | Notes About Effect Allele |
|---|---|---|---|---|---|
| PCSK9 | rs11591147 | -- | T | 0.01 | Decreased LDL-cholesterol; lower risk of heart disease. (good) |
| PCSK9 | rs28362286 | -- | A | 0.0003 | Decreased LDL-cholesterol; lower risk of heart disease. (good) |
| PCSK9 | rs67608943 | -- | G | 0.00004 | Decreased LDL-cholesterol; lower risk of heart disease. (good) |
| PCSK9 | rs72646508 | -- | T | 0.0001 | Decreased LDL-cholesterol; lower risk of heart disease. (good) |
| PCSK9 | rs505151 | -- | G | 0.04 | Increased LDL, increased risk of heart disease |
| PCSK9 | rs28942112 | -- | C | 0 | High LDL (important) |
| PCSK9 | rs28942111 | -- | A | 0 | High LDL (important) |
| PCSK9 | i5000370 | -- | C | 0 | High LDL (important) |
| PCSK9 | rs562556 | -- | G | 0.16 | GG: increased LDL, increased risk of adverse coronary events | AG: typical risk |
Lipoprotein(a):
Berberine has been shown to decrease cholesterol levels as well as decrease Lp(a) levels.[ref][ref](Be sure to read the full article on Lp(a) if you have either of the first two variants.)
| Gene | RS ID | Your Genotype | Effect Allele | Effect Allele Frequency | Notes About Effect Allele |
|---|---|---|---|---|---|
| LPA | rs3798220 | -- | C | 0.02 | risk of elevated Lp(a), increased risk for heart disease (important) |
| LPA | rs10455872 | -- | G | 0.06 | risk of elevated Lp(a), increased risk for heart disease (important) |
| LPA | rs6919346 | -- | T | 0.16 | decreased Lp(a) |
| LPA | rs41272114 | -- | T | 0.03 | decreased Lp(a) |
| LPA | rs143431368 | -- | C | 0.002 | decreased Lp(a) |
| LPA | rs6415084 | -- | T | 0.47 | higher Lp(a) levels, increased risk of heart disease (Chinese population group); no increased risk in Iranian or European Caucasian populations |
Cautions with berberine:
Berberine uses CYP3A4 and CYP2D6 enzymes for metabolism. Thus, it may interact with medications that also use those enzymes. If you are on prescription medications, talk with your doctor before adding in a bunch of berberine.
Check your CYP2D6 genetic variants and check your CYP3A4 variants here.
The interaction with berberine may be important if you have slower CYP2D6 or CYP3A4 function – along with taking a medication that utilizes these enyzmes.
Researchers also caution that people with G6PD deficiency may have side effects from berberine.
Your G6PD gene variants (full article):
| Gene | RS ID | Your Genotype | Effect Allele | Effect Allele Frequency | Notes About Effect Allele |
|---|---|---|---|---|---|
| G6PD | rs5030868 | -- | A | 0.001 | G6PD deficiency mutation |
| G6PD | rs72554664 | -- | T | 0.00007 | G6PD deficiency mutation |
| G6PD | rs1050828 | -- | T | 0.006 | G6PD deficiency mutation |
| G6PD | rs72554665 | -- | T | 0 | G6PD deficiency mutation |
| G6PD | rs5030869 | -- | T | 0.00009 | G6PD deficiency mutation |
| G6PD | rs137852327 | -- | T | 0.0001 | G6PD deficiency mutation |
| G6PD | rs137852330 | -- | A | 0 | G6PD deficiency mutation |
| G6PD | i5012739 | -- | T | 0 | G6PD deficiency mutation |
| G6PD | i3003411 | -- | T | 0.00009 | G6PD deficiency mutation |
| G6PD | i5008436 | -- | T | 0.0001 | G6PD deficiency mutation |
| G6PD | i5008440 | -- | A | 0 | G6PD deficiency mutation |
More articles that reference berberine:
- NAFLD: Berberine (500mg, 3x per day) resulted in a more significant decrease in liver fat and a greater reduction in weight, HOMAR-IR, and lipid profiles.[ref]
- PCOS: Several randomized clinical trials have found that berberine is as effective as metformin for PCOS.[ref][ref]
- SCD1 and metabolism: Berberine decreases SCD1 levels and decreases fatty liver in animal studies.[ref][ref]
- Leptin: Improved leptin ratios and decreased BMI after three months of berberine (300mg/3x per day).[ref]
- Psoriasis: Berberine decreases psoriasis symptoms when used topically.[ref][ref]
Detailed article on quercetin here.
Quercetin is a natural flavonoid that acts as both an antioxidant and an anti-inflammatory. It is found in low levels in many fruits and vegetables, including elderberries, apples, and onions.
| Key Benefits | Who May Benefit | Who Should Use Caution |
|---|---|---|
| – Decreases oxidative stress – Reduces blood pressure – Inhibits mast cell activation – Decreases uric acid – Fights upper respiratory infections |
– Individuals with histamine intolerance SNPs – Someone who wants to prevent gout – Individuals looking for natural ways to lower blood pressure |
– People on with slow COMT function who are also taking methyl donor supplements |
Quercetin may work well for:
Histamine intolerance:
Quercetin stabilizes mast cells and inhibits histamine release.[ref]Histamine intolerance genes (Please read the full article for details):
| Gene | RS ID | Your Genotype | Effect Allele | Effect Allele Frequency | Notes About Effect Allele |
|---|---|---|---|---|---|
| AOC1 | rs10156191 | -- | T | 0.26 | Reduced production of DAO |
| AOC1 | rs2052129 | -- | T | 0.23 | Reduced production of DAO |
| AOC1 | rs1049742 | -- | T | 0.07 | Reduced production of DAO |
| AOC1 | rs1049793 | -- | G | 0.31 | Reduced production of DAO |
| AOC1 | rs2071514 | -- | A | 0.19 | possibly slightly higher DAO |
| HMNT | rs1050891 | -- | A | 0.79 | Reduced breakdown of serum histamine |
| HMNT | i3000469 | -- | T | 0.1 | Reduced breakdown of serum histamine |
| HMNT | rs2071048 | -- | T | 0.58 | T/T: Reduced breakdown of serum histamine (common) |
| HMNT | rs11558538 | -- | T | 0.1 | Reduced breakdown of serum histamine |
| HDC | rs2073440 | -- | G | 0.02 | Decreased histamine production |
| HDC | rs267606861 | -- | A | 0 | rare pathogenic mutation, linked to Tourettes |
| HRH1 | rs901865 | -- | T | 0.17 | Increased H1 receptor, increased asthma risk |
| HRH2 | rs2067474 | -- | A | 0.04 | Decreased H2 receptor |
| HRH4 | rs11662595 | -- | G | 0.09 | decreased HRH4 activation (receptor dysfunction), increased risk of progression in non-small cell lung cancer |
| MTHFR | rs1801133 | -- | A | 0.33 | MTHFR C677T, decreased enzyme function, affects methylation cycle |
| MTHFR | rs1801131 | -- | G | 0.3 | MTHFR A1298C, slightly decreased enzyme function, slightly affects methylation cycle |
Gout genes:
A clinical trial using 500mg/day of quercetin for four weeks found that it decreased uric acid by 26·5 µmol/l on average.[ref]
| Gene | RS ID | Your Genotype | Effect Allele | Effect Allele Frequency | Notes About Effect Allele |
|---|---|---|---|---|---|
| ABCG2 | rs2231142 | -- | T | 0.1 | Increased risk of gout; higher uric acid |
| ABCG2 | rs72552713 | -- | A | 0.0003 | Increased risk of gout; higher uric acid |
| SLC2A9 | rs6449213 | -- | C | 0.19 | Decreased risk for gout; lower uric acid |
| SLC2A9 | rs7442295 | -- | G | 0.22 | Decreased risk for gout; lower uric acid |
| SLC2A9 | rs12510549 | -- | C | 0.2 | Decreased risk for gout; lower uric acid |
| SLC2A9 | rs12498742 | -- | G | 0.29 | Decreased risk for gout; lower uric acid |
| SLC2A9 | rs16890979 | -- | T | 0.23 | Decreased risk for gout; lower uric acid |
| SLC2A9 | rs1014290 | -- | G | 0.25 | Decreased risk for gout; lower uric acid |
| SLC2A9 | rs10805346 | -- | T | 0.54 | Decreased risk for gout; lower uric acid |
| SLC22A12 | rs475688 | -- | C | 0.74 | Higher risk of gout (common) |
| GCKR | rs780094 | -- | T | 0.04 | TT: higher risk of gout; CT and CC: lower risk of gout |
| SLC28A2 | rs2271437 | -- | G | 0.002 | Increased risk of gout |
Precautions with Quercetin:
COMT interaction:
Quercetin has a catechol structure and is partly metabolized through the COMT enzyme. If you carry the slower version of COMT, you may want to be careful and not go overboard with quercetin. This may be more important if taking more than one supplement that utilizes COMT (or at high doses).
| Gene | RS ID | Your Genotype | Effect Allele | Effect Allele Frequency | Notes About Effect Allele |
|---|---|---|---|---|---|
| COMT | rs4680 | -- | A | 0.48 | GG = higher activity; AG=Intermediate activity AA = lower activity |
| COMT | rs4633 | -- | T | 0.48 | CC = higher activity ; TT = lower COMT activity |
| COMT | rs6267 | -- | T | 0.003 | Minor decrease in COMT |
| COMT | rs165599 | -- | A | 0.64 | Minor decrease in COMT |
| COMT | rs165774 | -- | A | 0.29 | lower COMT activity; more likely to have irrational beliefs if subjected to maltreatment in childhood |
More articles that reference quercetin:
- Alopecia Areata: Animal and cell studies show quercetin stopped hair loss in AA.[ref][ref]
- NLRP3 inflammasome activation: Quercetin inhibits NLRP3 activation in cell and animal studies.[ref]
- Fatigue: Quercetin significantly inhibits IL-1β production.[ref]
- Inflammation and Depression: Animal studies show that quercetin effectively reduces depression and anxiety behavior.[ref][ref]
- Mast Cell Activation Syndrome Genes: Quercetin stabilizes mast cells and inhibits histamine release.[ref]
- APOE and Alzheimer’s Risk: Researchers theorize that oxidative stress contributes to Alzheimer’s disease pathology. Animal and cell studies show that quercetin can protect against oxidative stress in the brain and partially prevent the associated neuronal toxicity.[ref]
- Sirt3, Aging, and Mitochondrial Function: Quercetin also has beneficial effects in part through the SIRT3 pathway.[ref][ref]
- Lipedema: Quercetin is another antioxidant supplement that researchers suggest as being a likely candidate to help with lipedema.[ref]
- Nickel Allergy: In patients with known nickel allergies, quercetin supplements for three days before nickel contact decreased their reaction by more than 50%.[ref]
- Cold Sores: Quercetin has been shown in cell studies to lower herpes simplex virus infectivity.[ref]
| Key Benefits | Who May Benefit | Who Should Use Caution |
|---|---|---|
| – Decreases inflammatory cytokines – Reduces neuroinflammation – Better vascular function – Enhances immune response |
– Individuals with slow COMT wanting a natyrak anti-inflammatory – Someone who wants to prevent gout – Individuals looking for natural ways to lower blood pressure |
– People with CYP2C9 variants if taking other medications that utilize this enzyme |
Hesperidin may work well for:
Increased TNF-alpha:
Hesperidin, a natural flavonoid from citrus fruits, inhibits the release of TNF-alpha.[ref]
| Gene | RS ID | Your Genotype | Effect Allele | Effect Allele Frequency | Notes About Effect Allele |
|---|---|---|---|---|---|
| TNF | rs1800629 | -- | A | 0.15 | Increased TNF alpha, increased risk of many chronic inflammatory diseases |
| TNF | rs361525 | -- | A | 0.05 | Increased TNF alpha, increased risk of many chronic inflammatory diseases |
| TNF | rs1799964 | -- | C | 0.21 | Increased TNF alpha, increased risk of many chronic inflammatory diseases |
| TNF | rs1799724 | -- | T | 0.12 | Increased TNF alpha, increased risk of many chronic inflammatory diseases |
| TNFRSF1A | rs1800693 | -- | C | 0.39 | Increased risk of multiple sclerosis; increased NF-kB signaling |
| TNFRSF1A | rs767455 | -- | C | 0.42 | Increased risk of inflammatory diseases. |
| TNFRSF1B | rs1061622 | -- | G | 0.23 | Increased risk of psoriasis, lupus |
| TNF | rs1800610 | -- | A | 0.08 | Lower TNF; less inflammation but more susceptible to infectious diseases |
Lupus:
Blocking TNF may benefit lupus patients with specific variants.
| Gene | RS ID | Your Genotype | Effect Allele | Effect Allele Frequency | Notes About Effect Allele |
|---|---|---|---|---|---|
| HLA-DQA1 | rs2187668 | -- | T | 0.11 | HLA-DRB1*0301. 2-fold increase in risk for lupus. |
| TNXB | rs1150754 | -- | T | 0.12 | 2-fold increase in lupus risk |
| TNF | rs1800629 | -- | A | 0.15 | Some increase in Lupus risk |
| TNFAIP3 | rs5029939 | -- | G | 0.07 | 2x Increased risk of lupus |
| STAT4 | rs7574865 | -- | T | 0.22 | Increased risk of discoid lupus |
| STAT4 | rs10181656 | -- | G | 0.21 | Increased risk of lupus |
| IRF5 | rs3807306 | -- | T | 0.46 | Increased risk of lupus |
| IRF8 | rs2280381 | -- | C | 0.36 | Decreased risk of lupus |
| IFIH1 | rs1990760 | -- | T | 0.43 | Increased risk of lupus |
| BLK | rs13277113 | -- | A | 0.26 | B lymphoid tyrosine kinase, increased risk of lupus |
| BLK | rs2248932 | -- | A | 0.36 | B lymphoid tyrosine kinase, increased risk of lupus |
| IRF5 | rs10954213 | -- | A | 0.59 | Increased risk of lupus |
| TLR7 | rs179010 | -- | T | 0.3 | Increased relative risk of lupus |
| SLC15A4 | rs1385374 | -- | T | 0.1 | Increased relative risk of lupus |
| SLC15A4 | rs1385374 | -- | T | 0.1 | Increased relative risk of lupus |
Cautions with hesperidin:
Hesperetin is an inhibitor of CYP2C9. If you have variants below, read more here, and then use caution when combining with medications that are metabolized through that pathway.
CYP2C9 gene variants:
| Gene | RS ID | Your Genotype | Effect Allele | Effect Allele Frequency | Notes About Effect Allele |
|---|---|---|---|---|---|
| CYP2C9 | rs1799853 | -- | T | 0.1 | CYP2C9*2 decreased function |
| CYP2C9 | rs1057910 | -- | C | 0.06 | CYP2C9*3 decreased function |
| CYP2C9 | rs2256871 | -- | G | 0.006 | CYP2C9*9 decreased function |
| CYP2C9 | rs9332131 | -- | D | 0.0003 | CYP2C9*6 decreased function |
| CYP2C9 | rs28371685 | -- | T | 0.002 | CYP2C9*11 decreased function |
More articles that reference hesperidin:
- Alpha-1 Antitrypsin Deficiency: Hesperidin inhibits inflammation by blocking the release of TNF-alpha.[ref]
- Advanced Glycation End Products: Hesperidin can help upregulate glyoxalase 1, which may be helpful with AGEs. It does this by activating the Nrf2 pathway.[ref]
- Lipedema: A metabolite of hesperidin is recommended by researchers for lipedema, but there aren’t clinical trials on it yet.[ref][ref]
- Flu season: Hesperidin has been shown in several cell studies to inhibit the replication of influenza A. However, there aren’t any clinical trials of hesperidin for the flu.[ref]
Detailed article on Nattokinase
A natural component of Japanese Natto, nattokinase is an enzyme that helps to break down blood clots. The full article is full of references and clinical trial data on nattokinase.
| Key Benefits | Who May Benefit | Who Should Use Caution |
|---|---|---|
| – Helps to break down clots | – Individuals with elevated fibrinogen | – People on blood thinners, talk with your doctor if on medications |
Consider nattokinase for:
Elevated Fibrinogen:
Nattokinase may be something to consider for anyone with variants related to higher fibrinogen levels
| Gene | RS ID | Your Genotype | Effect Allele | Effect Allele Frequency | Notes About Effect Allele |
|---|---|---|---|---|---|
| FGA | rs6050 | -- | C | 0.26 | Increased risk of stroke, DVT, heart disease |
| FGA | rs2070022 | -- | A | 0.18 | Decreased fibrinogen, lower clot risk |
| FGB | rs1800787 | -- | T | 0.2 | Increased fibrinogen, incr. stroke risk |
| FGB | rs1800789 | -- | A | 0.2 | Increased fibrinogen, incr. stroke risk |
| FGB | rs1800790 | -- | A | 0.18 | Increased fibrinogen, incr. stroke risk |
| FGG | rs2066865 | -- | A | 0.23 | Increased fibrinogen; increased risk for DVT |
| FGG | rs2066860 | -- | T | 0.03 | Slightly increased risk of DVT |
Clotting and microclots may factor in small fiber neuropathy.
| Gene | RS ID | Your Genotype | Effect Allele | Effect Allele Frequency | Notes About Effect Allele |
|---|---|---|---|---|---|
| SCN9A | rs6746030 | -- | A | 0.12 | increased risk of arthritis pain, back pain (lumbar disc), and phantom pain |
| SCN9A | rs4369876 | -- | A | 0.009 | More sensitive to pain, increased risk of small fiber neuropathy |
| SCN9A | rs74449889 | -- | G | 0.005 | Increased risk of neuropathic pain |
| SCN9A | rs80356470 | -- | T | 0 | (rare) primary erythromelalgia |
| SCN9A | rs182650126 | -- | C | 0.003 | (rare) increased risk of neuropathy pain |
| SCN10A | rs6795970 | -- | A | 0.37 | Higher pain threshhold; decreased pain in inflammatory bowel disease |
| SCN10A | rs12632942 | -- | G | 0.24 | GG: lower pain threshold |
| SCN10A | rs151090729 | -- | T | 0.0008 | (rare mutation) hyperexcitable NaV1.8; increased risk of small fiber neuropathy |
| SCN11A | rs138607170 | -- | A | 0.00003 | (rare mutation) familial episodic pain syndrome, hereditary autonomic neuropathy |
| SCN11A | rs483352921 | -- | C | 0 | (rare mutation) familial episodic pain syndrome |
| SCN11A | rs483352920 | -- | G | 0 | (rare mutation) congenital insensitivity to pain |
| SCN11A | rs141686175 | -- | G | 0.0005 | (rare mutation) increased nerve firing, pain and neuropathy |
| TRPV1 | rs8065080 | -- | C | 0.37 | C/C: higher pain tolerance to pinprick pain (in Asian populations) |
Cautions with Nattokinase:
Please be sure to talk with your doctor if you are already on any anticoagulant or heart-related medications before taking nattokinase. Additionally, nattokinase is derived from natto, which is fermented. It is possible that people with histamine-related issues could notice an increase in histamine from nattokinase.
More articles that reference nattokinase:
- Factor V Leiden: A Mutation in factor V increases the risk of aberrant clotting and DVTs.
Read the full CoQ10 article
CoQ10 is used in cells as an antioxidant, immune modulator, and regulator of NAD+ — and for ATP production in the mitochondria.
| Key Benefits | Who May Benefit | Who Should Use Caution |
|---|---|---|
| – Lipid-soluble antioxidant to prevent oxidized LDL and promote heart health – Anti-inflammatory, impacting IL-1 and TNF-alpha – Benefits the immune response – Benefits mitochondrial function |
– Individuals with statin side effects
– Migraine sufferers – People with ME/CFS |
– People on blood thinners, talk with your doctor if on medications |
Consider CoQ10 for:
Statins and Brain Fog:
In addition to lowering cholesterol, statins reduce CoQ10 levels. A meta-analysis of randomized controlled trials shows that CoQ10 levels are reduced in all types of statin users.[ref][ref]
| Gene | RS ID | Your Genotype | Effect Allele | Effect Allele Frequency | Notes About Effect Allele |
|---|---|---|---|---|---|
| HMGCR | rs17244841 | -- | A | 0.96 | A/A: statins are more likely to work well in reducing LDL through inhibiting HMGCR |
| HMGCR | rs12916 | -- | C | 0.4 | C/C: less cholesterol-lowering response on moderate doses of statins |
| HMGCR | rs17238540 | -- | T | 0.97 | T/T: statins are more likely to work well in reducing LDL through inhibiting HMGCR |
| HMGCR | rs3846662 | -- | G | 0.45 | typical response to statins |
Migraine prevention:
CoQ10 (400 mg/day) reduced the frequency and severity of migraines.[ref]
| Gene | RS ID | Your Genotype | Effect Allele | Effect Allele Frequency | Notes About Effect Allele |
|---|---|---|---|---|---|
| TRPM8 | rs10166942 | -- | C | 0.23 | decreased risk of migraines (temperature and menthol receptor gene) |
| BDNF | rs6265 | -- | T | 0.18 | Increased risk of migraines due to lower BDNF |
| MMP16 | rs10504861 | -- | T | 0.21 | Reduced risk of migraines |
| NNMT | rs694539 | -- | T | 0.18 | TT only: 4-fold increase in migraine risk (methylation cycle) |
| MTHFR | rs1801133 | -- | A | 0.33 | Increased risk of migraines (methylation cycle) |
| C7orf10 | rs4379368 | -- | T | 0.11 | Decreased risk of migraines (serotonin) |
| SLC6A4 | rs2066713 | -- | A | 0.37 | Decreased risk of migraines (serotonin) |
| AOC1 | rs1049793 | -- | G | 0.31 | Increased risk of migraines (histamines from foods) |
| AOC1 | rs10156191 | -- | T | 0.26 | Increased risk of migraines (histamines from foods) |
| TNF | rs3093664 | -- | G | 0.07 | Increased risk of migraines (inflammatory pathway) |
| TNF | rs1800750 | -- | A | 0.01 | Increased risk of migraines (inflammatory pathway) |
| TNF | rs1800629 | -- | A | 0.15 | Increased risk of migraines (inflammatory pathway) |
| IL1A | rs17561 | -- | A | 0.28 | Increased risk of migraines (inflammatory pathway) |
| KCNK18 | rs869025175 | -- | D | 0.0003 | rare mutation (talk with your doctor) |
| MTDH | rs1835740 | -- | T | 0.24 | This variant is linked to glutamate regulation. Glutamate is an excitatory neurotransmitter. |
| LRP1 | rs11172113 | -- | C | 0.39 | Less likely to have migraines caused by cholesterol |
| NRP1 | rs2506142 | -- | G | 0.19 | 2-fold increased risk of menstrual migraine |
| PHACTR1 | rs9349379 | -- | A | 0.61 | Increased risk of migraines |
| TRPV1 | rs8065080 | -- | C | 0.37 | C/T: more likely to have chronic migraines; C/C: protective against chronic migraines |
Cautions with CoQ10:
Talk with your doctor if you are on warfarin or statins and have concerns about interactions with CoQ10.
More articles that reference CoQ10:
- Egg Quality when TTC: CoQ10 may be helpful in improving egg quality for women trying to get pregnant.
- Migraine prevention: CoQ10 (400 mg/day) reduced the frequency and severity of migraines.[ref]
- Fatigue (ME/CFS): Supplementing with 150mg of ubiquinol, a form of CoQ10, improved cognitive function in people with CFS/ME.[ref]
- Inclusion Body Myositis: CoQ10 and carnitine may help reduce symptoms for some individuals.[ref]
Nicotinamide Riboside (NR) and Nicotinamide Mononucleotide (NMN)
NAD+ is an essential part of mitochondrial energy production. As we age, our NAD+ levels decline, and researchers believe this may tie into a lot of chronic diseases related to aging. NR and NMN are supplements that can increase NAD+ levels.
Consider NR or NMN for:
Infertility:
Several studies have shown that NMN or NAD+ precursors restore fertility at the end of an animal’s normal reproductive age. It seems to do this through rejuvenating egg quality.[ref]
| Gene | RS ID | Your Genotype | Effect Allele | Effect Allele Frequency | Notes About Effect Allele |
|---|---|---|---|---|---|
| MTHFR | rs1801133 | -- | A | 0.33 | MTHFR C677T; reduced folate enzyme efficiency |
| MTHFR | rs1801131 | -- | G | 0.3 | MTHFR A1298C; reduced folate enzyme efficiency |
| F5 | rs6025 | -- | T | 0.02 | Factor V Leiden; increased clot risk and miscarriage risk |
| F2 | rs1799963 | -- | A | 0.01 | Prothrombin variant; increased risk of clots and miscarriage |
| LHCGR | rs13405728 | -- | G | 0.08 | Luteinizing hormone and hCG receptor; Increased risk of PCOS |
| LHCGR | rs2293275 | -- | T | 0.41 | Luteinizing hormone and hCG receptor; Increased risk of PCOS |
| DENND1A | rs10818854 | -- | A | 0.04 | Increased androgen synthesis; Increased risk of PCOS |
| FSHB | rs11031006 | -- | A | 0.13 | Increased lutenizing hormone to FSH ratio |
| FSHR | rs6166 | -- | C | 0.44 | Folicle-stimulating hormone receptor; Increased PCOS risk |
| ADIPOQ | rs2241766 | -- | G | 0.1 | lower risk of PCOS (good); T/T has higher risk of PCOS which can impact fertility |
| ADIPOQ | rs1501299 | -- | T | 0.25 | TT: Decreased risk of PCOS (good) |
| MTNR1B | rs10830963 | -- | G | 0.27 | Melatonin receptor in pancreas; increased risk of PCOS and higher insulin levels |
| F2 | i3002432 | -- | A | 0.001 | Prothrombin variant; increased risk of clots and miscarriage |
Tendonitis:
Cell and animal studies show that NMN decreases inflammation while promoting healing in tendons.[ref]
| Gene | RS ID | Your Genotype | Effect Allele | Effect Allele Frequency | Notes About Effect Allele |
|---|---|---|---|---|---|
| COL1A1 | rs1800012 | -- | A | 0.16 | A/A: significantly reduced risk of Achilles’ tendon tear (good) |
| COL5A1 | rs12722 | -- | T | 0.49 | higher risk of Achilles’ tendinopathy (lower levels of COL5A1); increased risk of tennis elbow |
| MIR608 | rs4919510 | -- | G | 0.21 | Associated with chronic Achilles' tendinopathy |
| BMP4 | rs2761884 | -- | T | 0.4 | Increased risk of tendinopathies |
| FCRL3 | rs7528684 | -- | G | 0.45 | Increased risk of tendinopathies |
| TNF | rs1800629 | -- | A | 0.15 | Higher TNF-alpha levels; increased risk of Achilles tendon problems and knee tendon problems |
| MMP13 | rs2252070 | -- | T | 0.68 | Increased risk of posterior tibial tendon problems (flat foot) |
| MMP1 | rs1144393 | -- | C | 0.35 | Increased risk of posterior tibial tendon problems (flat foot) |
| MMP3 | rs650108 | -- | G | 0.72 | G/G: increased risk of tendinopathies (athletes) |
| MMP3 | rs679620 | -- | T | 0.48 | T/T: increased risk of tendinopathies (athletes) |
| GDF5 | i6011281 | -- | A | 0.57 | A/A: higher risk of achilles tendon (common genotype) |
| GDF5 | rs143383 | -- | A | 0.57 | A/A: higher risk of achilles tendon (common genotype) |
Precautions with NR or NMN:
The research is not totally clear on whether NR or NMN could promote cancer growth. I would err on the side of caution until the research is conclusive if I was battling cancer. NAD+ levels decline significantly with age. Research doesn’t show a benefit for taking NR or NMN in people who are young and healthy since they are likely to have sufficient NAD+ already.
More articles that reference NR and NMN:
- Long Covid: AgelessRX has a clinical trial underway using low-dose naltrexone and nicotinamide riboside.[ref]
- Depression and Mitochondrial Function: Nicotinamide riboside (NR) reduces inflammation in the brain and improves cognitive function in animal studies.[ref]
- Inclusion Body Myositis: A recent study (Jan. 2021) showed that increasing NAD+ levels via nicotinamide riboside may help with mitochondrial muscle function. The study used animal and cell models (not a randomized trial).[ref]
Read the full article on creatine
Creatine is an amino acid important in energy production in brain tissue and muscles. It is produced from a reaction that includes the amino acids glycine and arginine, along with a methyl group.
Consider creatine for:
Creatine synthesis genetic variants: Genetic variants can impact how your cells make creatine.
| Gene | RS ID | Your Genotype | Effect Allele | Effect Allele Frequency | Notes About Effect Allele |
|---|---|---|---|---|---|
| GATM | rs1346268 | -- | C | 0.29 | reduced risk of muscle pain with statins; likely higher levels of GATM |
| GATM | rs80338737 | -- | A | 0 | rare mutation linked to Arginine:glycine amidinotransferase deficiency |
| CKM | rs8111989 | -- | C | 0.32 | found in higher frequency in elite combat sport athletes; slightly better physical performance; possibly more creatine kinase |
| CKM | rs11559024 | -- | C | 0.01 | decreased creatine kinase levels |
| CKM | rs4884 | -- | G | 0.69 | protective against knee osteoarthritis (good) |
MTHFR:
The MTHFR gene encodes an enzyme that is important in the methylation cycle and production of methyl groups. A methyl group is needed for the synthesis of creatine, so for people who have limitations on the methylation cycle, supplemental creatine may help take the strain off the pathway.
| Gene | RS ID | Your Genotype | Effect Allele | Effect Allele Frequency | Notes About Effect Allele |
|---|---|---|---|---|---|
| MTHFR C677T | rs1801133 | -- | A | 0.33 | 40-70% decrease in MTHFR enzyme function (folate metabolism) |
| MTHFR A1298C | rs1801131 | -- | G | 0.3 | 10-20% decrease in MTHFR enzyme function (folate metabolism) |
High homocysteine:
Supplemental creatine can help to lower homocysteine levels in healthy people with good kidney function.[ref][ref][ref]
| Gene | RS ID | Your Genotype | Effect Allele | Effect Allele Frequency | Notes About Effect Allele |
|---|---|---|---|---|---|
| MTHFR | rs1801133 | -- | A | 0.33 | MTHFR C677T, higher homocysteine levels, especially if folate is lacking |
| NOX4 | rs11018628 | -- | C | 0.06 | decreased homocysteine, decreased stroke risk |
| MTR | rs1805087 | -- | G | 0.19 | increased risk of cognitive impairment due to higher homocysteine |
| MTR | rs2275565 | -- | T | 0.22 | associated with higher homocysteine levels |
| MTRR | rs1801394 | -- | G | 0.5 | somewhat increased homocysteine levels, especially if riboflavin is low |
| CBS | rs5742905 | -- | G | 0.005 | risk of increased homocysteine, responsive to vitamin B6 |
| PEMT | rs7946 | -- | T | 0.68 | TT: homocysteine increases with low folate diet |
| BHMT | rs3733890 | -- | A | 0.3 | reduced conversion of choline to betaine |
Cautions with creatine:
Creatine is used in clinical trials without side effects, but there are cautions for people with kidney disease. Talk with your doctor if you have any health concerns with creatine.
More articles that reference creatine:
- AMPD1 deficiency:
Creatine supplements have been used to prevent muscle soreness in people with AMPD1 deficiency. Studies have shown varying results for the impact of creatine.[ref][ref] - Mood or depression:
Clinical trials show creatine may help with depression caused by a lack of brain energy or oxidative stress.[ref]