Dive into the ways that your genes impact the detoxification of substances such as mold, arsenic, plastics, and more.
PFAS “forever chemicals” accumulate in blood and tissue and resist normal clearance. This article covers their health effects and the genetic factors that shape individual susceptibility.
A small percentage of people taking bisphosphonates will experience osteonecrosis – bone death – in the jaw. Genetic variants are part of the susceptibility.
ABCB1 encodes P-glycoprotein, a transporter that removes toxins – and medications – from the body. Genetic variants in the ABCB1 gene can affect how well a medication works for you.
Multiple Chemical Sensitivity involves systemic reactions to low-level chemical exposures. Genetic research points to detox enzyme variants and olfactory gene interactions.
Genetic variants in the ORPM1 gene impact both the amount of pain someone experiences and their response to opioid drugs. These variants are also important in susceptibility to opiate addiction.
Microplastics research shows that these microscopic bits of plastics are a real problem for health and wellness.
BPA, a chemical found in some plastics, has been linked to a variety of health issues in people. Learn more about BPA and the research into genetic responses to this chemical.
Mushrooms contain a healthy antioxidant called ergothioneine. But for people with a SLC22A4 genetic variant, this antioxidant can be too much of a good thing, leading to intestinal problems. Check your genetic data to see if you carry this mushroom intolerance variant.
Glutathione is an antioxidant produced in all cells to balance out ROS. Genetic variants can impact your glutathione levels, which can alter your ability to detoxify certain substances or withstand stressors in the body.
Statins are one of the most prescribed medications in the world. One side effect of statins is myopathy, or muscle pain and weakness. Your genetic variants are significant in whether you are likely to have side effects from statins.
Mycotoxins from food and water-damaged buildings are cleared via CYP450, GST, and UGT pathways. Variants in these detox genes explain why mold and mycotoxin sensitivity varies.
Glyphosate is the active ingredient in the herbicide Round-Up. A recent study showed that people with CYP1A1 genetic variants are more likely to have problems with acetylcholinesterase inhibition from glyphosate.
Phthalates are a type of chemical used as plasticizers to make plastics more pliable. There has been a lot of research on the endocrine-disrupting effects of phthalates. Your genetic variants may impact whether phthalates are a problem for you.
Check your raw data to see if you have DPYD mutations that affect the toxicity of 5-FU (fluorouracil) cancer drugs.
High blood lead levels are influenced by exposure and by genetic variants. Learn how your genes impact lead levels, and what to do about it.
Discover how genetics and liver health influence acetaminophen metabolism and the risk of liver damage. Learn about the role of CD44, SULT, UGT, and GST genes.
The use of low dose naltrexone (LDN) can be an effective treatment for some autoimmune diseases, pain syndromes, and chronic fatigue syndrome. Learn how this opioid antagonist works on the immune system and how your genetics can play a part in its efficacy.
Discover the pros and cons of fluoride for dental health and overall wellness, its sources, toxicity levels, and how genetics influence fluoride sensitivity.
What are the physiological effects of mercury and how does the body eliminates it? Discover how genetic variants play a role in how quickly you excrete mercury.
Arsenic exposure occurs via well water, in certain foods, and through breathing. This article covers the pathways the body uses to get rid of arsenic, and it includes information on genetic variants that may impair the detoxification of arsenic.
Genetics plays a role in the susceptibility to antibiotic allergies. Learn which genetic variants increase your risk.
Is buying organic worth the extra cost? Pesticides that are sprayed on conventionally grown foods affect people differently. Some people carry genetic variants that decrease their ability to detoxify specific pesticides, others may be more resilient. This is Part One in a multipart series on pesticide detoxification. (Member’s article)
Genetic variants impact how well the flu antiviral medication, Tamiflu, works for an individual. Learn how your genes impact this medication. (Member’s article)
Ever wonder why a certain medication may work great for a friend and do nothing for you? One reason could be the genes involved in transporting the medication into and out of your cells. This article looks at the research studies on fexofenadine and the Multidrug Resistance Protein variants.
Wondering why you don’t react the same way to alcohol as your friends do? Some people metabolize alcohol faster leaving a build-up of acetaldehyde. Learn more about why this can be a health problem for some.