ABCC4 (MRP4) Gene: Drug Transport, Genetic Variants, and Medication Response
Learn how the ABCC4 (MRP4) gene transports drugs, toxins, cAMP, and prostaglandins. Explore common variants, medication interactions, and factors that alter ABCC4 activity.
Detoxification of Substances
Dive into the ways that your genes impact the detoxification of substances such as mold, arsenic, plastics, and more.
PFAS, Mitochondrial Function, Immune Response, and Genetics
PFAS “forever chemicals” accumulate in blood and tissue and resist normal clearance. This article covers their health effects and the genetic factors that shape individual susceptibility.
Risk of Osteonecrosis from Bisphosphonates
A small percentage of people taking bisphosphonates will experience osteonecrosis – bone death – in the jaw. Genetic variants are part of the susceptibility.
ABCB1 (P-glycoprotein): Response to Medications, HRT, and Environmental Toxins
ABCB1 encodes P-glycoprotein, a transporter that removes toxins – and medications – from the body. Genetic variants in the ABCB1 gene can affect how well a medication works for you.
Mold, Mycotoxins, and Your Genes: Detox Pathways, Symptoms, and SNPs
Mycotoxins from food and water-damaged buildings are cleared via CYP450, GST, and UGT pathways. Variants in these detox genes explain why mold and mycotoxin sensitivity varies.
Multiple Chemical Sensitivity (MCS): Genetics, Causes, and Solutions
Multiple Chemical Sensitivity involves systemic reactions to low-level chemical exposures. Genetic research points to detox enzyme variants and olfactory gene interactions.
Opioid Receptors Genetic Variants and Addiction
Genetic variants in the OPRM1 gene impact both the amount of pain someone experiences and their response to opioid drugs. These variants are also important in susceptibility to opioid addiction.
Microplastics Research Roundup
Microplastics research shows that these microscopic bits of plastics are a real problem for health and wellness.
BPA and BPS: How Your Genes Influence Bisphenol Detoxification
BPA, a chemical found in some plastics, has been linked to a variety of health issues in people. Learn more about BPA and the research into genetic responses to this chemical.
Mushroom Intolerance: Ergothioneine and the OCTN1 Gene
Mushrooms contain a healthy antioxidant called ergothioneine. But for people with a SLC22A4 genetic variant, this antioxidant can be too much of a good thing, leading to intestinal problems. Check your genetic data to see if you carry this mushroom intolerance variant.
Glutathione: Master Antioxidant, Reducing Oxidative Stress, and Detoxification
Glutathione is an antioxidant produced in all cells to balance out ROS. Genetic variants can impact your glutathione levels, which can alter your ability to detoxify certain substances or withstand stressors in the body.
Will statins give you muscle pain? SLCO1B1 and ABCG2
Statins are one of the most prescribed medications in the world. One side effect of statins is myopathy, or muscle pain and weakness. Your genetic variants are significant in whether you are likely to have side effects from statins.
Glyphosate Exposure: Genetics and the Impact on Our Health
Glyphosate is the active ingredient in the herbicide Round-Up. A recent study showed that people with CYP1A1 genetic variants are more likely to have problems with acetylcholinesterase inhibition from glyphosate.
Arsenic Metabolism Genes: Exposure, Elimination, and Ways to Reduce It
Explore arsenic metabolism genes, including AS3MT, GSTO1, and MTHFR, plus practical ways to reduce arsenic exposure from water and food.
Phthalates: Genes, Diet, and Detoxification Pathways
Phthalates are a type of chemical used as plasticizers to make plastics more pliable. There has been a lot of research on the endocrine-disrupting effects of phthalates. Your genetic variants may impact whether phthalates are a problem for you.
DPYD (Dihydropyrimidine Dehydrogenase) and 5-fluorouracil Reactions
Check your raw data to see if you have DPYD mutations that affect the toxicity of 5-FU (fluorouracil) cancer drugs.
Getting the Lead Out: Genetics and Lead Exposure
High blood lead levels are influenced by exposure and by genetic variants. Learn how your genes impact lead levels, and what to do about it.
Acetaminophen Toxicity: Genetic Susceptibility and Environmental Factors
Discover how genetics and liver health influence acetaminophen metabolism and the risk of liver damage. Learn about the role of CD44, SULT, UGT, and GST genes.
Low-Dose Naltrexone: LDN & Genetics
The use of low dose naltrexone (LDN) can be an effective treatment for some autoimmune diseases, pain syndromes, and chronic fatigue syndrome. Learn how this opioid antagonist works on the immune system and how your genetics can play a part in its efficacy.
Fluoride: Health Effects And Detoxification Genes
Discover the pros and cons of fluoride for dental health and overall wellness, its sources, toxicity levels, and how genetics influence fluoride sensitivity.
Mercury Detoxification: Genomics and Solutions
What are the physiological effects of mercury and how does the body eliminates it? Discover how genetic variants play a role in how quickly you excrete mercury.
Antibiotics: Genetics and Antibiotic Reactions
Genetics plays a role in the susceptibility to antibiotic allergies. Learn which genetic variants increase your risk.
Should you eat organic? Detoxifying Neonicotinoids
Is buying organic worth the extra cost? Pesticides that are sprayed on conventionally grown foods affect people differently. Some people carry genetic variants that decrease their ability to detoxify specific pesticides, others may be more resilient. This is Part One in a multipart series on pesticide detoxification. (Member’s article)
Tamiflu: Genetic Reasons it May not Work for You
Genetic variants impact how well the flu antiviral medication, Tamiflu, works for an individual. Learn how your genes impact this medication.
Allergy Medicine: Why Fexofenadine Works Better for Some People
Ever wonder why a certain medication may work great for a friend and do nothing for you? One reason could be the genes involved in transporting the medication into and out of your cells. This article looks at the research studies on fexofenadine and the Multidrug Resistance Protein variants.