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- Learn how your genes influence your health, nutrition, longevity, and wellness.
- Discover the research-backed solutions that work for specific genetic variants.
- Decide what will work best for you.
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Latest Articles and Genotype Reports:
Longevity and Health Aging
- APOE and COMT: Cognitive performance in aging
Your APOE and COMT genotypes together may impact memory and cognitive function in older age. - BPIFB4 Gene: Linked to Longevity and Heart Health
Discover the impact of the BPIFB4 gene on longevity and immunity, and find out if you have the longevity variant in your genotype report. - Alpha-Ketoglutarate: A Key to Healthspan and Fighting Age-Related Diseases
Supplementing with Alpha-ketoglutarate (αKG) might be beneficial for longevity since it plays a role in energy production and inflammation reduction.
Supplements & Genes
- Saffron Extract: What does the research show?
Recent clinical trials show that saffron extract is as effective as standard medications in some people for ADHD, Alzheimer’s, major depressive disorder, and high cholesterol. - Agmatine: Neuropathic pain and mood
Acting as a neurotransmitter and neuromodulator, agmatine holds promise for neuropathic pain, depression, and brain function. - Lion’s Mane: Cognitive function, nerve regeneration
Lion’s mane mushrooms have a long history of being used as a medicinal food for increasing energy, improving nerve function, and boosting brain power.
>>>More in Supplement Research >>>
Vitamins and Foods: Nutrigenomics
- Wilson’s disease: ATP7B gene mutations and copper in the brain
Mutations in ATP7B can cause copper dysregulation and Wilson’s disease. People carrying one copy of the mutation may also have subtle changes. - Fructose Intolerance: Hereditary or Dietary?
Fructose intolerance can be due to a rare mutation in the ALDOB gene or it can be due to reduced intestinal absorption. - Nickel Allergy: Genetics, causes, natural solutions
Nickel allergy can cause sensitivity to foods that contain nickel. Learn about how genes increase susceptibility and solutions.
>>> More in Vitamins and Foods >>>
Hormones & Your Genes
- Hot flashes, genetics, and natural solutions
Hot flashes affect up to 80% of women going through menopause. Genetics, environment, and diet can make them worse. Target the right solutions. - CYP17A1: Steroid Hormone Production and Metabolism
CYP17A1 is important in the production of steroid hormones including testosterone and estrogen. SNPs in CYP17A1 impact hormone levels. - Maca Root: Research-backed Benefits and How It Works
Explore the benefits of Maca root, a cruciferous vegetable with adaptogenic properties, known for balancing hormone levels and aiding menopausal symptoms. Learn about its potential side effects, gene interactions, and the science behind its unique bioactive compounds.
Disease Prevention: Genetic Guides
- Osteoarthritis: The Role of Genetics and Natural Solutions
Inflammation and breakdown of cartilage are at the root of osteoarthritis. Learn how your genes impact the pathways involved in arthritis. - COMT in Pain Disorders
Genetic polymorphisms in COMT affect how we feel certain types of pain. These variants are linked to increased susceptibility to chronic pain disorders. - BH4: Tetrahydrobiopterin Synthesis, Recycling, and Genetic SNPs
Tetrahydrobiopterin (BH4) is an essential cofactor in the production of neurotransmitters and nitric oxide. Genetic variants impact BH4 levels which can affect heart disease, cognitive function, and immune response.
More in Disease Prevention >>>
Sleep and Circadian Rhythms
- Histamine, Mast Cell Activation, and Early Morning Insomnia
Histamine rising in the early morning hours may cause early waking insomnia. Mast cells and circadian rhythm disruption at the root. - Boost Slow-Wave Sleep with Glycine Before Bed
Sleep quality is essential for good health and our genetics play a role in how much slow wave sleep we naturally get. - DEC2 Gene: Short Sleep Mutation
Are you naturally a short sleeper? Mutations in the DEC2 gene decrease the need for sleep.
More in Sleep & Circadian Rhythm >>>
Explore by Symptoms, Supplements, Diet, or Pathway:
Lifestyle & Diet
acupuncture alcohol anthocyanins aspartame athletics caffeine carbs choline coffee cruciferous vegetables fasting fiber fodmaps gluten healthspan iron keto light at night liver longevity organic polyphenols saturated fat sauna sleep
Supplements
Akkermansia muciniphila alpha-ketogluterate alpha-lipoic acid andrographis apigenin ashwagandha astaxanthin astragalus bacopa berberine biotin calcium calcium d-glucurate carnitine cat's claw CBD cinnamon copper CoQ10 cordyceps creatine curcumin d-mannose dihydromyricetin EGCG fisetin fish oil frankincense ginkgo biloba ginseng glycine glycyrrhizin hesperidin inositol iodine l-arginine l-theanine lion's mane lithium orotate lutein luteolin magnesium manganese melatonin methylene blue methylfolate NAC naringenin niacin nicotinamide riboside nigella sativa NMN noopept PEA peppermint probiotics quercetin reishi resveratrol rhodiola riboflavin rosemary rutin selenium St. Johns wort sulforaphane taurine thiamine vitamin A vitamin B12 vitamin B6 vitamin C vitamin D vitamin E vitamin K zinc
Symptoms
allergies anemia anxiety arthritis blood pressure brain fog depression dysautonomia eyes fatigue gallbladder hair loss heavy menstrual bleeding high blood pressure intestinal issues migraines neuropathy pain peripheral nerves POTS sinus skin small fiber neuropathy stress teeth tremor
Pathways & Processes
acetylcholine AGEs anandamide arachidonic acid autophagy bile acids bone brown fat cannabinoids catecholamines cholesterol circadian rhythm clots cognitive cold collagen complement system connective tissue dopamine endothelium GABA ghrelin glutathione GSTs gut microbiome heat shock proteins histamine hypoxia inborn error of metabolism inflammation intelligence klotho lactose lungs macrophages mannose binding lectin mast cells methylation microbiome mitochondria mTOR muscle neurons non-secretor oxidative stress plant sterols platelets pro-resolving mediators senescence serotonin sirtuins T cells taste receptor tryptophan tyramine uric acid vagus nerve vascular
Diseases, Conditions
adenovirus ADHD alpha-1 antitrypsin Alzheimer's asthma autism bipolar cancer celiac cystic fibrosis diabetes dry eyes Ehlers-Danlos epilepsy Epstein-Barr virus fibroids fibromyalgia flu gout heart hemochromatosis IBD infertility lupus lyme ME/CFS miscarriage multiple sclerosis NAFLD nickel obesity osteoporosis osteoporsis Parkinson's PCOS periodontal periodontitis Propionibacterium acnes psoriasis rheumatoid arthritis seasonal affective disorder Sjogren vaccination vaccines virus
Genes, Proteins
ACE ADAMS adora2a APOE BDNF BH4 CCR5 COMT Covid GLP-1 GSTM1 GSTP1 hemoglobin HLA HMGB1 homocysteine HPA IGF1 IL-13 IL-17 IL-18 IL-1A IL-1B IL-6 interferon-gamma lp(a) MAO NF-kB nitric oxide NLRP3 telomeres TLR4 TNF-alpha TRPV1 UGTs X chromosome
Hormones
Medications
anesthesia antibiotics aspirin CYP450 drugs metformin nicotine NSAIDs psychodelics rapamycin statins
Toxins
Heart Health: Genetic Guides
- Homocysteine: Genetics and Solutions
High homocysteine levels are strongly linked to an increased relative risk of cardiovascular diseases. Find out how your genes impact homocysteine levels. - Plasminogen Activator Inhibitor-1 (PAI-1): Regulator of clotting
Plasminogen Activator Inhibitor (PAI-1) is an important enzyme in the regulation of the breakdown of blood clots and fibrosis. Genetic variants impact the amount of PAI-1. - BPIFB4 Gene: Linked to Longevity and Heart HealthDiscover the impact of the BPIFB4 gene on longevity and immunity, and find out if you have the longevity variant in your genotype report.
Metabolic Health Genes
- Lipedema: Genes, Root Causes, Possible Solutions
Lipedema is a fairly common cause of excess thigh and leg fat that is bumpy and tender to touch. Genes play a role in lipedema. - HbA1c: Heritability of A1C testing
For some people, genetic variants can cause HbA1c levels not to accurately reflect their average blood glucose levels. Find out how your genes impact A1c readings. - Blood glucose levels: how your genes impact blood sugar regulation
Genetics plays a significant role in your blood glucose regulation. Discover your genetic susceptibility to blood sugar problems to help with blood glucose stability.
Inflammation and Immune Response
- Osteoarthritis: The Role of Genetics and Natural SolutionsInflammation and breakdown of cartilage are at the root of osteoarthritis. Learn how your genes impact the pathways involved in arthritis.
- COMT in Pain DisordersGenetic polymorphisms in COMT affect how we feel certain types of pain. These variants are linked to increased susceptibility to chronic pain disorders.
- Low IgA and Selective IgA Deficiency
Partial IgA deficiency, which affects up to 1% of the population, can have a genetic component and overlaps with some autoimmune diseases.
More articles in Inflammation and Immune >>>
Traits: Genetic Guides
- Dyslexia: Genes + Early Life Stressors
While dyslexia is known to run in families, the role of genetics in dyslexia is still being determined. Here is a quick look at some of the genes involved in dyslexia, affecting around 10% of the population. - Mosquito Bite Genes: Are you a mosquito magnet?
Do you feel like you are a magnet for mosquitoes? Genetic variants do play a role in how attractive you are to mosquitoes. - Will you go bald? Genetics and hair loss
What causes male pattern baldness? A combination of genetics, nutrition, and environmental toxins come together to form the risk factors for baldness. But genetics really seems to rule the roost here.
Mood and Brain Genes
- Dyslexia: Genes + Early Life StressorsWhile dyslexia is known to run in families, the role of genetics in dyslexia is still being determined. Here is a quick look at some of the genes involved in dyslexia, affecting around 10% of the population.
- Is Inflammation Causing Your Depression and Anxiety? The Science Behind the Link
Discover why inflammation causes depression and how your genetic variants in inflammatory genes may play a role in depression or anxiety. - ADHD Genes: Exploring the Role of Genetics, Environment, and Neurochemistry in ADHD
Discover the complex interplay of genetics and environment in ADHD susceptibility. Learn how circadian rhythm and neurotransmitter genes contribute to the disorder, and how toxicant exposure may increase risk.
Fertility & Pregnancy
- Trying to get pregnant? Targeted Approaches to Improving Egg Quality
Trying to get pregnant? Healthy eggs are vital for a successful pregnancy. Discover four key ways to improve your egg quality, according to research studies. - Folate Optimization: MTHFR and Fertility
MTHFR variants affect the conversion of folate into the active form. Learn how this can affect you if you are trying to get pregnant. - Genetic Causes of Male Infertility
Almost 10% of couples worldwide struggle with infertility. Learn more about your genetic susceptibility and dig deeper into the lifestyle factors that could affect your sperm.
Detoxification & Medications
- Multiple Chemical Sensitivity (MCS): Genetics, Causes, and Solutions
Struggling with Multiple Chemical Sensitivity (MCS)? Learn about the connection between genetics, detoxification enzymes, and the olfactory system. Discover how targeting specific genetic variants can help alleviate symptoms. - Phthalates: Genes, Detoxification, and Diet
Phthalates are a type of chemical used as plasticizers to make plastics more pliable. There has been a lot of research on the endocrine-disrupting effects of phthalates. Your genetic variants may impact whether phthalates are a problem for you. - Naltrexone: LDN & Genetics
The use of low dose naltrexone (LDN) can be an effective treatment for some autoimmune diseases, pain syndromes, and chronic fatigue syndrome. Learn how this opioid antagonist works on the immune system and how your genetics can play a part in its efficacy.
Autoimmune Disease Genes
- Multiple Chemical Sensitivity (MCS): Genetics, Causes, and SolutionsStruggling with Multiple Chemical Sensitivity (MCS)? Learn about the connection between genetics, detoxification enzymes, and the olfactory system. Discover how targeting specific genetic variants can help alleviate symptoms.
- Naltrexone: LDN & GeneticsThe use of low dose naltrexone (LDN) can be an effective treatment for some autoimmune diseases, pain syndromes, and chronic fatigue syndrome. Learn how this opioid antagonist works on the immune system and how your genetics can play a part in its efficacy.
- Decoding the Genetic Factors Behind Multiple Sclerosis
MS susceptibility is linked to both genetic causes and environmental factors. Learn how those two combine – and possible solutions.
More articles in Autoimmune >>>
Methylation Cycle Genes
- Homocysteine: Genetics and SolutionsHigh homocysteine levels are strongly linked to an increased relative risk of cardiovascular diseases. Find out how your genes impact homocysteine levels.
- Folate Optimization: MTHFR and FertilityMTHFR variants affect the conversion of folate into the active form. Learn how this can affect you if you are trying to get pregnant.
- Creatine: Boosting Muscles and Increasing Brain Power
Creatine is an amino acid used in muscle tissue and the brain for energy in times of stress. Genes play a role in creatine synthesis. Find out what the research shows about creatine supplements for muscle mass and cognitive function.
My Story…
Hi! I’m Debbie Moon. Welcome to Genetic Lifehacks.
When I first had my genetic data sequenced, I was both amazed at the research available in academic journals and frustrated by the difficult language and disconnected topics.
Genetic Lifehacks began as a way to share what I was learning about genetics with my family and friends.
My goal has always been to freely share information so that everyone can benefit.
As the website grew in popularity, I decided that I needed to know more… both more about genetics and more about how the pieces of the biological systems fit together. Since my undergraduate degree was in engineering, I went back to school and received my Master’s degree in Biological Sciences from Clemson University in 2019.
Now a full-time endeavor, Genetic Lifehacks has reached over 2.5 million readers, equipping people to use their genetic data to optimize their health.
~ Debbie Moon, Founder of Genetic Lifehacks