Understand your genetic data and optimize your health and diet.

Genetic Lifehacks makes it simple to use your genetic data to learn about health and wellness, using your existing data from 23&Me, AncestryDNA, and more.

Discover your risks, learn about research-backed solutions, and find out your best diet, supplement, and lifestyle options.

Join me on the journey of optimizing health using research-backed solutions.


Metabolic Health Genes

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Detoxification & Medications
  • Glyphosate: Interaction with Genetics
    Glyphosate is the active ingredient in the herbicide Round-Up. A recent study showed that people with CYP1A1 genetic variants are more likely to have problems with acetylcholinesterase inhibition from glyphosate.
  • Detoxifying Phthalates: Genes and Diet
    Phthalates are a type of chemical used as plasticizers to make plastics more pliable. There has been a lot of research on the endocrine-disrupting effects of phthalates. Your genetic variants may impact whether phthalates are a problem for you.
  • CYP2B6: Genetic variants impacting medication reactions
    The CYP2B6 enzyme is part of the body’s first line of defense in detoxifying and breaking down certain and important for metabolizing several medications. Genetic variants of this enzyme can either speed up or slow down its function.

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Explore by Topic:

Over 370 articles explaining genetics, health, longevity, and optimization:

Popular search terms: Histamine, MTHFR, Depression, COMT

Inflammation and Immune Response:
  • TNF alpha: Inflammation, Genetics, and Natural Inhibitors
    Do you feel like you are constantly dealing with inflammation? Joint pain, food sensitivity, etc.? Perhaps you are genetically geared towards a higher inflammatory response. Tumor necrosis factor (TNF) is an inflammatory cytokine that acts as a signaling molecule in our immune system.
  • Beating Flu Season
    Are you more genetically susceptible to the flu? Will Tamiflu work for you? Learn how your genes play a role and discover research-backed natural options to beat the flu.
  • Estrogen, histamine, and mast cell connections
    Mast cells can be more easily triggered in the presence of high estrogen or estrogen-mimicking compounds. Histamine can also trigger mast cell degranulation. Together, this can cause a lot of symptoms related to mast cell activation.

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Autoimmune Disease Genes

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Mood and Brain Genes
  • Key Genes to check for Alcohol Use Disorder
    Learn more about the genetic connections to alcohol addiction, how to check your genetic raw data, and what research-backed treatment options are available.
  • HPA Axis Dysfunction: Cortisol and Stress
    Cortisol is a hormone produced by the adrenal glands in times of stress, and it also plays many roles in your normal bodily functions. It is a multi-purpose hormone that needs to be in the right amount (not too high, not too low) and at the right time. Your genes play a big role in how likely you are to have problems with cortisol.
  • Intelligence Genes
    Hundreds of identified genes influence intelligence, from IQ scores to musical ability. Learn more about your intelligence strengths and ways to enhance your cognitive function.

>>>More in Mood and Brain >>>

Traits: Genetic Guides

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Vitamins and Foods: Nutrigenomics

>>> More in Vitamins and Foods >>>

Heart Health: Genetic Guides

>>>More in Heart Health >>>

Supplements & Genes

>>>More in Supplement Research >>>

Disease Prevention: Genetic Guides
  • Key Genes to check for Alcohol Use Disorder
    Learn more about the genetic connections to alcohol addiction, how to check your genetic raw data, and what research-backed treatment options are available.
  • Parkinson’s Disease: Genetic Pathways
    Parkinson’s disease (PD) is not yet fully understood. Researchers think that it is caused by a combo of genetics and environmental factors. Learn more about this disease and the factors that lead to susceptibility.
  • BChE gene: Nightshade sensitivity, Anesthesia risk
    Genetic variants of the BChE gene decrease its enzyme’s activity. This can lead to various and seemingly unconnected consequences…such as an increased risk for Parkinson’s or food sensitivity to potatoes.

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Methylation Cycle Genes
  • Creatine: Boosting Muscles and Increasing Brain Power
    Creatine is an amino acid used in muscle tissue and the brain for energy in times of stress. Genes play a role in creatine synthesis. Find out what the research shows about creatine supplements for muscle mass and cognitive function.
  • What is MTHFR? Is it important?
    The MTHFR gene is important for how your body utilizes folate (vitamin B9) for creating neurotransmitters, detoxifying toxicants, and maintaining a healthy heart. Check your 23andMe or AncestryDNA data for the MTHFR C677T and A1298C variants.
  • CBS Gene Variants and Low Sulfur Diet
    Some clinicians recommend a low sulfur diet for people with CBS mutations. Find out what the research shows – and why that recommendation is not backed up. (Member’s article)

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Fertility & Pregnancy
  • MTHFR and Pregnancy
    MTHFR variants affect the conversion of folate into the active form. Learn how this can affect you if you are trying to get pregnant.
  • Genetic Causes of Male Infertility
    Almost 10% of couples worldwide struggle with infertility. Learn more about your genetic susceptibility and dig deeper into the lifestyle factors that could affect your sperm.
  • Recurrent miscarriage: Genes and Inflammation
    Learn about how genetic variants in certain inflammatory cytokines can increase or decrease the risk of recurrent miscarriage.

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My Story…

Hi! I’m Debbie Moon. Welcome to Genetic Lifehacks.

When I first had my genetic data sequenced, I was both amazed at the research available in academic journals and frustrated by the difficult language and disconnected topics.

Genetic Lifehacks began as a way to share what I was learning about genetics with my family and friends.

My goal has always been to freely share information so that everyone can benefit.

As the website grew in popularity, I decided that I needed to know more… both more about genetics and more about how the pieces of the biological systems fit together. Since my undergraduate degree was in engineering, I went back to school and received my Master’s degree in Biological Sciences from Clemson University in 2019.

Now a full-time endeavor, Genetic Lifehacks has reached over 2.5 million readers, equipping people to use their genetic data to optimize their health. 

Debbie Moon, Founder of Genetic Lifehacks