GLP-1 Genetics: How Genes Affect Appetite, Semaglutide, and Tirzepatide Response
Genes affect how well semaglutide (Ozempic) and tirzepatide work. Check your GLP-1 receptor gene variants linked to weight loss response. Genotype report included.
Metabolic Health Genetics: Blood Sugar, Weight, and Diabetes Risk
Metabolic health encompasses good blood glucose regulation, ideal LDL and triglycerides, normal blood pressure, and an average waist circumference.
Where to start for metabolic health:
- Check out how your genes impact your risk for diabetes.
- See whether you’re at a higher genetic risk of NAFLD (fatty liver).
- Find out about your GLP-1 genes and medications.
Looking for information on weight loss? Check out all the articles specific to weight.
Members: Check out the Metabolic Health Topic Summary Report for a quick overview of all your genetic variants related to your metabolic health.
Latest articles about Metabolic Health:
Artificial Sweeteners: Sucralose, Aspartame, and Genetic Interactions
Health effects of artificial sweeteners, including sucralose and aspartame, and their genetic interactions.
GLP-1: Genetic Variants Related to GLP-1 RA Medications
GLP-1 receptor agonists are used for weight loss by increasing the body’s sensitivity to insulin and reducing hunger. However, genetic variants can alter the response in some people.
Very Long Chain Acyl-CoA Dehydrogenase Deficiency (VLCAD)
VLCAD deficiency causes the mitochondria to be unable to use long-chain fatty acids for energy production. This can result in hypoglycemia or mitochondrial dysfunction.
Lipedema: Genes, Root Causes, Possible Solutions
Lipedema is a fairly common cause of excess thigh and leg fat that is bumpy and tender to the touch. Genes play a role in lipedema.
FTO and m6A Methylation: Heart Health, Obesity, and Genetics
Recently, researchers discovered that FTO is an m6A eraser that removes methyl groups from mRNA. This discovery has opened up huge avenues of research on topics from cancer to immune response to heart disease.
Fatty Liver Disease: Genetics and Reasons for NAFLD, MASLD
Non-alcoholic fatty liver disease (NAFLD) can be caused by genetic susceptibility, diet, and lifestyle factors. The good news is that fatty liver disease is reversible.
Medium Chain Acyl-CoA Dehydrogenase Deficiency: Genetics, Carriers, and Symptoms
Medium-chain acyl-CoA dehydrogenase (MCAD) deficiency is an “inborn error of metabolism” which impairs the body’s ability to break down medium-chain fatty acids for fuel. Learn more about this metabolic disorder.
Picking the Right Weight Loss Diet for Your Genes
Is there an easy way to compare what diet might be best based on your genotype? Research shows some interesting associations between genotype and diet interactions and weight loss.
Adenoviruses: Causing Weight Gain and Obesity
There have been several interesting studies linking obesity to a viral infection, specifically an adenovirus. Learn more about this virus and its association with obesity.
Insulin Resistance and Genetics: Finding the Root Cause
Genetics combined with diet causes insulin resistance. While dietary sugar can be involved, genetic research points to BCAAs as having a causal role in IR.
Short-chain Acyl-CoA Dehydrogenase Deficiency
If you have tried fasting or perhaps a ketogenic diet and felt horrible, there could be a genetic reason. You might carry a genetic mutation that causes SCADD (short-chain acyl-CoA dehydrogenase deficiency).
Eating Habits: Snacking and Hunger Genes
Your genetic variants can influence your propensity for snacking and how/when you feel hungry. Learn about Leptin, FGF21, FTO, emotional eating, and more.
LDL Cholesterol: Genetics, Personalized Solutions
Your genes combine with your diet to influence your LDL cholesterol level. Learn more about why LDL cholesterol levels may matter in heart disease and find out how your genes are important here.
Genetics and Type 2 Diabetes
Not all type 2 diabetes risk is from what you eat… Genetics plays a big role in diabetes. Learn more about your genetic susceptibility.
HbA1c: Heritability of A1C Testing
For some people, genetic variants can cause HbA1c levels not to accurately reflect their average blood glucose levels. Find out how your genes impact A1c readings.
Blood Glucose Levels: Genetics and Blood Sugar Regulation
Genetics plays a significant role in your blood glucose regulation. Discover your genetic susceptibility to blood sugar problems to help with blood glucose stability.
Adiponectin levels, food choices, and genetics
Although production occurs in adipose tissue, those with more fat tissue usually have lower adiponectin levels. Lower adiponectin levels (and thus high inflammation) have links to chronic issues associated with obesity.
Genetic Links to High Uric Acid and Gout
High uric acid levels can cause the pain and inflammation seen in gout. Find out how your genetic variants influence your uric acid levels and gout risk.
SCD1: A lynchpin of metabolism
The SCD1 enzyme converts saturated fatty acids to unsaturated fats. Learn how your genes impact this enzyme, and how this relates to weight loss.
Decrease your diabetes risk with coffee?
Does coffee increase or decrease your risk of prediabetes? Learn more about coffee consumption and your genetic risk. (Member’s article)
PCOS: Causes, Genetics, and Natural Solutions
Explore the complexities of PCOS, including symptoms, hormonal dysregulation, and the role of genetics. Learn how to target individual pathways.
Diabetes: Genetic Risk Report
We often talk about diabetes as though it is one disease, but diabetes can have several different causes or pathways that are impacting glucose regulation. Tailoring your diabetes prevention (or reversal) efforts to fit your genetic susceptibility may be more effective. Use your genetic raw data to learn more about diabetes and your genetic risk.
SIRTfoods diet: Sirtuins and Turning on your Skinny Genes
The SIRTfood diet, made popular by Adele’s recent weight loss, theoretically works by affecting your sirtuin gene expression. Learn about your SIRT genes and your genetic variants.
Ghrelin: The Hunger Hormone
The hunger hormone, ghrelin, is important in appetite regulation and satiety. Learn how your genes interact with your diet when it comes to ghrelin levels. (Member’s article)