Is Inflammation Causing Your Depression and Anxiety? The Science Behind the Link
Discover why inflammation causes depression and how your genetic variants in inflammatory genes may play a role in depression or anxiety.
Mood and Brain
Understanding how your genes impact your neurotransmitters can help you to better optimize mood and cognitive function.
Members: Start with the Brain and Mood Topic Summary Report for a quick visual way to know which articles to read first.
ADHD Genes: Exploring the Role of Genetics, Environment, and Neurochemistry in ADHD
Discover the complex interplay of genetics and environment in ADHD susceptibility. Learn how circadian rhythm and neurotransmitter genes contribute to the disorder, and how toxicant exposure may increase risk.
The Warrior Gene: Understanding the Role of Monoamine Oxidase Enzymes (MAOA and MAOB)
The MAOA and MAOB genes encode enzymes that break down certain neurotransmitters. People with low MAO may be prone to mood issues in certain circumstances.
Alcohol Addiction: Exploring the Genetic and Environmental Factors
Discover the role of genetics, stress, and neurotransmitters in alcohol use disorder. Alcohol dependence is complex; understand your genes and the research on treatment options.
HPA Axis Dysfunction: Understanding Cortisol and Genetic Interactions
Cortisol is a hormone produced by the adrenal glands in times of stress, and it also plays many roles in your normal bodily functions. It is a multi-purpose hormone that needs to be in the right amount (not too high, not too low) and at the right time. Your genes play a big role in how likely you are to have problems with cortisol.
Lithium Orotate and Vitamin B12: Benefits for Mood and Cognitive Support
For some people, low-dose, supplemental lithium orotate is a game changer when combined with vitamin B12. But other people may have little to no response. The difference may be in your genes.
Genetics and Intelligence: IQ-Influencing Genes and Paths to Optimization
Hundreds of identified genes influence intelligence, from IQ scores to musical ability. Learn more about your intelligence strengths and ways to enhance your cognitive function.
Anxiety: Genetics, heredity, and personalized solutions
When it comes to anxiety, genetic variants combine with environmental factors (nutrition, sleep, relationships, etc) when it comes to anxiety. Understanding your anxiety genes can help you figure out which pathways to target.
Exploring the Roots of Dyslexia: How Genes and Early Life Stressors Contribute to Reading Disorders
While dyslexia is known to run in families, the role of genetics in dyslexia is still being determined. Here is a quick look at some of the genes involved in dyslexia, affecting around 10% of the population.
Brain Fog: Causes, genetics, and individualized solutions
Explore brain fog in detail, looking at the physiological causes, genetic susceptibility, and personalized solutions.
Tryptophan Pathways: Kynurenine, Serotonin, and Melatonin
Tryptophan is an amino acid that the body uses to make serotonin and melatonin. Genetic variants can impact the amount of tryptophan that is used for serotonin. This can influence mood, sleep, neurotransmitters, and immune response.
GABA: Genetics, Anxiety, and Immune Response
GABA (gamma-Aminobuyteric acid) is a neurotransmitter that acts to block or inhibit a neuron from firing. It is an essential way that the brain regulates impulses, and low GABA levels are linked with several conditions, including anxiety and PTSD.
Identify Your Root Cause(s) of Depression
Depression can have multiple physiological causes. This article ties together 9 separate articles on depression to simply your genetic search.
Migraines: Genes, Root Causes, and Personalized Solutions
Your genes play a role in your susceptibility to migraines. Find out what is going on when you have a migraine and solutions that fit your genes.
Nootropics and Genetics: Smart Drugs and Your Genes
Nootropics are supplements used to boost cognition and memory. Learn how the substance works and the genes connected to the mechanism of action.
L-theanine for anxiety: Genetics and nature’s chill pill
L-theanine is known for reducing anxiety and promoting sleep. Discover the many benefits of l-theanine and how supplementation might work for you.
Psychopaths: Born not made?
Can you be born a psychopath? Are there genes linked to psychopathy? Discover how your genes don’t predestine you to become a psychopath.
Best Supplements to Boost BDNF
Is it smart to boost your BDNF levels? Discover more by digging into the research studies that show when, how, and why it is important to focus on BDNF.
Serotonin: How your genes affect this neurotransmitter
Serotonin is a neurotransmitter that is important in depression, sleep, and many other aspects of health. Learn how your genetic variants in the serotonin receptor genes impact their function.
VMAT2 gene: The God Gene and Neurotransmitters
An examination of the current research for the ‘God gene’, explaining what it does and its importance in Parkinson’s disease.
Depression, genetics, and mitochondrial function
How does mitochondrial dysfunction relate to major depressive disorder? Learn about the causes of mitochondrial dysfunction as well as genetic variants that link the risk of depression to the mitochondria.
MTHFR, depression, anxiety, symptoms and treatment
We are all genetically unique, and a common genetic variant in the MTHFR gene causes some people to be more susceptible to having low folate levels. This article explains the research linking MTHFR variants, folate, and depression — and gives you information on how diet or supplements may help.
COMT: Slow vs. Fast, Interactions with Supplements
Some supplements interact with COMT variants to impact the rate at which neurotransmitters are broken down. Check your COMT genotype and discover how this may affect your reaction to different supplements or combinations of supplements.
Serotonin 2A receptor: Psychedelic response and Alzheimer’s disease
Learn how new research on brain aging and dementia connects the serotonin 2A receptor with psychedelics, brain aging, and Alzheimer’s.
ANK3: Bipolar Disorder and Brain Development
The genetic variants in the ANK3 gene impact the risk of psychiatric disorders that include bipolar disorder and autism spectrum disorders, and heart arrhythmia. Discover how ANK3 impacts neuronal formation and transmission and how this ties into an increased risk of psychiatric disorders.
Why Circadian Rhythm Disruption Causes Depression
For some people, circadian disruption can be chronic – and at the heart of depression or mood disorders. Genetic variants play a role in this susceptibility. Fortunately, there are solutions that may help.