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Longevity

Learn how YOUR genes impact longevity and healthspan, and then apply the research-based Lifehacks to optimize your health and prevent the diseases of aging.

Where to start?

Members: Check out the Longevity Topic Summary Report for a quick overview of all your genetic variants related to longevity.
Genetic variants that cause Hemochromatosis, symptoms of Hemochromatosis

Building Up Iron: Hemochromatosis Mutations

A couple of common mutations can cause you to build up iron, leading to iron overload or hemochromatosis. It is one genetic disease where knowledge is really powerful – you can completely prevent hemochromatosis through blood donations.

HMB for muscle growth, HMB for to prevent age related muscle loss, HMB caution with autoimmune diseases

HMB Supplement and Muscle Mass

HMB – hydroxymethylbutyrate – is a supplement that helps to prevent muscle loss in aging and may help with building muscle when working out.

SIRT3 gene variants, Aging, longevity, and Mitochondrial Function

SIRT3, Aging, and Mitochondrial Function

How we age is just as important as how long we live. Examine how sirtuins play a part in the aging process by how they regulate our cellular health.

Genetics and Environmental factors of Skin Aging

Skin Aging: Using Genomics to Solve Wrinkles and Age Spots

Some people age naturally with beautiful-looking skin. Others slather on creams and odd gunk in a futile battle to chase away wrinkles and age spots. What is the difference? Genetics and environmental factors, of course.

Longevity Genes: Hacking healthspan using genomics

Longevity Genes: Hacking Healthspan Using Genomics

Several genes have been identified as longevity genes, linked to an increase in lifespan. Most importantly, these particular genetic variants show links to a longer ‘healthspan’. Check your genetic data to see if you carry the FOXO3A and IGF1R variants associated with healthy longevity.

mTOR, how rapamycin works, downsides of rapamycin

Rapamycin, mTOR, and Your Genes

Rapamycin is an antibiotic used as an immunosuppressant, an anti-cancer agent, and to prevent blocked arteries. Rapamycin is now the focus of longevity and healthspan-extending research by inhibiting mTOR.

Genetic Mutations (variants) that protect against alzheimers, strategies for reducing alzheimer's

Genetic Mutations that Protect Against Alzheimer’s Disease

Just like there are genetic variants that increase the risk of Alzheimer’s, there are also variants that protect against this disease. Check your genetic data to get a better picture of your risk factors. (Member’s article)

TREM2 Gene and Alzheimer’s Disease Risk, role of TREM2 in microglia autophagy, ways to increase TREM2

TREM2 and Alzheimer’s Disease Risk

The TREM2 gene is important in how the brain’s immune system functions. Learn how variants in this gene impact the risk for Alzheimer’s disease.

Age-Related Macular Degeneration Genes

Age-Related Macular Degeneration Genes

Age-related macular degeneration (AMD) is the most common cause of blindness in the elderly. You will find supplements specifically promoted for preventing AMD. This article explains age-related macular degeneration, delves into the genetic risks, and then explains which supplements are likely to be protective and which may do more harm than good.

NOS3: Heart Health, Blood Pressure, and Healthy Aging

Nitric Oxide Synthase (NOS3): Heart Health, Blood Pressure, and Healthy Aging

Nitric Oxide Synthase is an important signaling molecule in the endothelium of our blood vessels. It has roles in the regulation of blood pressure, cardiovascular disease, brain health, and more. Genetic variants in nitric oxide genes are important for a healthy heart. Find out how your genes could play a part in the interactions with cardiovascular disease risk and blood pressure.

Melatonin: Key to Health and Longevity, melatonin synthesis pathway

Melatonin: Key to Health and Longevity

More than just a sleep hormone, melatonin is at the heart of many health topics. Your genetic variants play a big role in the production of melatonin. Learn how your lifestyle and diet interact with your melatonin-related genes.

Metformin: Longevity Research and Genetics

Metformin: Longevity Research and Genetics

A decades-old diabetes drug now holds promise for increasing healthspan. Research shows that metformin may reduce the risk of some of the diseases of aging, thus increasing the number of years someone is healthy.

Advanced Glycation End Products

Advanced Glycation End Products (AGEs): Genetics, Lifestyle, and Health Span

One cause of many of the diseases of aging is the buildup of advanced glycation end products (AGEs). Your genes interact with your diet – and cooking methods – in the build-up of AGEs. Learn whether this is something that is important for you to focus on. (Member’s article)