Taurine: Healthspan, Mitochondrial Function, and Heart Health
Taking a deep dive into the science behind taurine – from antiaging supplement to heart and digestive health. Genetics plays a role in who may benefit most from supplemental taurine.
Supplement Research
Do you ever wonder if a supplement actually works – or if it is all just hype? My goal here is to present unbiased research on natural supplements and to explore how genetic variants impact the effect of supplements. The articles explain how each supplement is absorbed, transported, and metabolized — all areas where individual genetic variants can make a difference in outcomes.
Where to start?
- Lithium orotate and B12 – For anyone dealing with irritability, anger, or low mood.
- Nattokinase and Lumbrokinase – Preventing blood clots or dissolving microclots
- Luteolin – as an antihistamine, for decreasing brain fog, and anti-inflammatory
- Berberine – research studies on the absorption problems and benefits for the immune response and cholesterol
Latest articles about Supplement Research:
AHCC: Mushroom Compound That Modulates NK and T Cells
AHCC, a mushroom extract, boosts NK cells and T cells. Learn what the studies show for HPV, immune health, and chemotherapy support — plus drug interactions.
Which Type of Choline Works Best with Your Genes?
Which choline supplement works best based on your PEMT, MTHFD1, and CHKA genes? Compare citicoline, alpha-GPC, PC, and betaine.
Nicotinamide Riboside and NMN: Boosting NAD+ in Aging with Supplements
Explore the research about how nicotinamide riboside (NR) and NMN are being used to reverse aging. Learn about how your genes naturally affect your NAD+ levels and how this interacts with the aging process.
Urolithin A for Mitochondrial Health and Muscle Function: Genetic Connections and Research Studies
Urolithin A supports mitochondrial function and muscle health. Discover how your gut produces it, who benefits most from supplements, and what the research shows.
C15:0 (Pentadecanoic Acid): Benefits, Food Sources, Endogenous Synthesis, and Fatty 15 Supplements
C15:0 (pentadecanoic acid) is an odd-chain saturated fatty acid linked in multiple studies to health benefits. Learn how to increase synthesis through dietary changes.
Lithium Orotate and Vitamin B12: Benefits for Mood and Cognitive Support
For some people, low-dose, supplemental lithium orotate is a game changer when combined with vitamin B12. But other people may have little to no response. The difference may be in your genes.
BPC-157: Tendon Repair and More
BPC-157 (body protection compound-157) is a peptide derived from human gastric juice that is 15 amino acids in length. Studies show that it promotes the healing of different tissues, including skin, muscle, bone, and tendons.
Thymosin Beta 4: Genetics & Supplemental Peptides
Thymosin beta 4 is a natural peptide that is made in the body and helps with wound healing, muscle recovery, and decreasing inflammation. It is also available as a supplemental peptide.
Cordyceps: Clinical Trials, Mechanism of Action, and Genetic Connections
Cordyceps mushroom extract has immunomodulatory and anti-inflammatory effects. Studies show benefits for asthma, resistance training, endurance training, and kidney disease.
Alpha-Ketoglutarate (AKG) Supplements: What the Research Actually Shows [2026 Update]
Alpha-ketoglutarate for longevity: the science behind AKG supplements, including clinical trials, brain health, joint protection, supplement forms, and dosing.
DHFR and MTHFR: Folic Acid Metabolism
Methylfolate and folic acid—what’s the difference? Learn how DHFR and MTHFR variants affect folic acid metabolism, unmetabolized folic acid, cancer and autism risk, BH4 recycling, and how to choose the right supplement for your genes.
Methylene Blue: Genetic Connections and Research Studies
Methylene blue has neuroprotective and anti-inflammatory properties, but it isn’t for everyone. Learn about the genetic variants that throw a caution flag on this one.
Nattokinase and Lumbrokinase: Natural Supplements for Clotting and Heart Health
Two natural fibrinolytics to reduce clotting are nattokinase and lumbrokinase. Learn more about these options based upon the newest research and clinical trials.
Resveratrol: Studies, Genetic Interactions, and Bioavailability
Resveratrol is a polyphenol with anti-inflammatory and antioxidant properties. Studies show that it affects heart health, bone health, cognitive function, and metabolic health.
Supplements with Genetic Connections
Linking supplements and genetic SNPs so that you can more easily find out what may work for you – and what to be cautious about.
HMB Supplement and Muscle Mass
HMB – hydroxymethylbutyrate – is a supplement that helps to prevent muscle loss in aging and may help with building muscle when working out.
DAO Enzyme Supplements: Research Studies and Genetic Connections
DAO enzyme supplements work by providing the enzyme needed to break down histamine in food and from the gut microbiome.
Sulforaphane: Studies, Genetic Connections
Overview of sulforaphane research studies, bioavailability, and genetic interactions. Learn about dosage, supplements, and natural sources.
Creatine: Boosting Muscles and Increasing Brain Power
Creatine is an amino acid used in muscle tissue and the brain for energy in times of stress. Genes play a role in creatine synthesis. Find out what the research shows about creatine supplements for muscle mass and cognitive function.
Bryan Johnson’s Blueprint Protocol with Genetic Links
Overview of Bryan Johnson’s million dollar longevity protocol, with genetic insight to make it personalized and cheaper.
Shilajit: Muscles, Bones, and Testosterone
Shilajit is a supplement that contains fulvic acid, metabolites, and minerals. It has been used for centuries in Ayurvedic medicine, and clinical trials show it has positive benefits for osteoporosis, testosterone, male infertility, and muscle recovery.
Saffron Extract: What does the research show?
Recent clinical trials show that saffron extract is as effective as standard medications in some people for ADHD, Alzheimer’s, major depressive disorder, and high cholesterol.
Agmatine: Neuropathic pain and mood
Acting as a neurotransmitter and neuromodulator, agmatine holds promise for neuropathic pain, depression, and brain function.
Lion’s Mane: Cognitive function, nerve regeneration
Lion’s mane mushrooms have a long history of being used as a medicinal food for increasing energy, improving nerve function, and boosting brain power.