What a tantalizing idea to take a natural supplement and notice fabulous results – energy, health, immunity!  But, reality is often not the same as the sales hype.

This section consists of unbiased research on different supplements, without the sales pitch. We are all unique, so the articles explain  how genetics matters in how a supplement may work for you.  


In a nutshell, hesperidin is a flavonoid found in citrus fruits that is anti-inflammatory and may help with cardiovascular health and preventing neuroinflammation. Learn more about the research studies on this interesting flavonoid, including a link to COVID-19.


Why do some people get such great benefits from CBD while others notice nothing? It is likely that your genes play a role in how your body responds to CBD. This article covers the research studies on CBD, the receptors that CBD binds to, and how your genetic variants could be influencing your response (or lack thereof) to CBD oil.


Berberine is a supplement that I've written about as a 'Lifehack' in a number of different articles. It is a natural compound with some amazing research on it in animal and cell studies, and it seems to be almost unbelievable. The drawback is poor absorption in the intestines, which can decrease its effectiveness.

Supplemental Plant Sterols

Plant sterols are known as a 'heart healthy' way to lower cholesterol. But, it turns out that they may only lower cholesterol only in people with certain genetic variants. Check your genes to see if adding plant sterols is worthwhile for you.


Quercetin is a natural flavonoid that acts both as an antioxidant and anti-inflammatory. As a supplement, quercetin has many positive health benefits. This article focuses on the results of clinical trials involving quercetin as well as linking to specific genetic topics.

NAD+ article including human studies on NR and NMN

NR and NMN to boost NAD+

Nicotinamide riboside (NR) and nicotinamide mononucleotide (NMN) are two supplements that have taken the longevity and anti-aging world by storm. With animal studies showing exciting results including reversal of age-related diseases, these supplements are an exciting glimpse into the future of reversing aging.


A decades-old diabetes drug now holds promise for increasing healthspan. Research shows that metformin may reduce the risk of some of the diseases of aging, thus increasing the number of years someone is healthy.

Will Modafinil work for you?

Modafinil is being used as a nootropic drug that increases alertness and gives a sense of well being — to some users. Like most drugs, individual results seem to vary. One reason for the variation is a common genetic variation in the COMT gene.

Lithium: Alzheimer's prevention, telomeres, longevity

Several good studies link higher natural levels of lithium in the ground water to decreased Alzheimer's rate. Additionally, clinical trial on lithium for Alzheimer's show promise. Learn more and decide whether this may be a longevity supplement for you. ​

Fisetin: Antioxidant and Senolytic

Could this natural flavonol found in fruits and vegetables be the newest piece to the anti-aging puzzle? New studies are starting to show support for its benefits. This article probes the evidence for using fisetin as a longevity compound and explores the research on supplemental fisetin’s health benefits.

Lithium Orotate

For some people, supplementing with lithium orotate helps with anxiety, mood, and anger issues. Learn about the connection with vitamin B12 and genetic variants that influence B12 levels.

Folic acid vs Methylfolate

The DHFR gene is key to breaking down folic acid to be used by the body. Variants in this gene can cause limits to the amount of folic acid you can metabolize at one time.