Supplements… We all love the idea of taking a (usually natural) supplement and having wonderful results from it.  But the reality is often not the same as the hype. 

These articles dig into the solid, unbiased research on different supplements, and then goes one step further to explain how genetics may come into play in regards to whether the supplement will work for you.  


Berberine is a supplement that I've written about as a 'Lifehack' in a number of different articles. It is a natural compound with some amazing research on it in animal and cell studies, and it seems to be almost unbelievable. The drawback is poor absorption in the intestines, which can decrease its effectiveness.


Why do some people get such great benefits from CBD while others notice nothing? It is likely that your genes play a role in how your body responds to CBD. This article covers the research studies on CBD, the receptors that CBD binds to, and how your genetic variants could be influencing your response (or lack thereof) to CBD oil.


A decades-old diabetes drug now holds promise for increasing healthspan. Research shows that metformin may reduce the risk of some of the diseases of aging, thus increasing the number of years someone is healthy.

Will Modafinil work for you?

Modafinil is being used as a nootropic drug that increases alertness and gives a sense of well being — to some users. Like most drugs, individual results seem to vary. One reason for the variation is a common genetic variation in the COMT gene.


Quercetin is a natural flavonoid that acts both as an antioxidant and anti-inflammatory. As a supplement, quercetin has many positive health benefits. This article focuses on the results of clinical trials involving quercetin as well as linking to specific genetic topics.

NAD+ article including human studies on NR and NMN

NR and NMN to boost NAD+

Nicotinamide riboside (NR) and nicotinamide mononucleotide (NMN) are two supplements that have taken the longevity and anti-aging world by storm. With animal studies showing exciting results including reversal of age-related diseases, these supplements are an exciting glimpse into the future of reversing aging.

Lithium Orotate

For some people, supplementing with lithium orotate helps with anxiety, mood, and anger issues. Learn about the connection with vitamin B12 and genetic variants that influence B12 levels.

Folic acid vs Methylfolate

The DHFR gene is key to breaking down folic acid to be used by the body. Variants in this gene can cause limits to the amount of folic acid you can metabolize at one time.