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NLRP3 Inflammasome, Genetics, and Chronic Inflammation

NLRP3: Genetic Variants that Increase Chronic Inflammation

Explore NLRP3 inflammasome genetics: How variants drive chronic inflammation in Alzheimer’s, diabetes, and autoimmune diseases. Discover triggers, health risks, and lifehacks like zinc & vitamin D to modulate it.

mTOR, how rapamycin works, downsides of rapamycin

Rapamycin, mTOR, and Your Genes

Rapamycin is an antibiotic used as an immunosuppressant, an anti-cancer agent, and to prevent blocked arteries. Rapamycin is now the focus of longevity and healthspan-extending research by inhibiting mTOR.

HMGB1: From Nuclear Organizer to Inflammatory Alarmin

HMGB1 gene: inflammatory response protein important in sepsis and COVID-19

The HMGB1 protein has a unique role in activating the inflammatory response pathways. Increased HMGB1 levels will call up the troops for a big response to an infection. Discover how genetic variants of this protein vary the risk of cancer, inflammation, and sepsis to name a few.