You’ve spit in the little tube, mailed it off to 23andMe or AncestryDNA, and finally, your results are available. Yay! What can you learn from your genetic data?
Download it first: Here’s how to download your data from 23andMe. Here’s how to download your data from AncestryDNA.
It’s your data, and you should keep it.
Start here on Genetic Lifehacks for free information on your 23andMe raw data:
There is a ton of information on Genetic Lifehacks, all referenced to quality research studies.
My goal is to curate the best evidence and not make speculative claims. I simply explain the research and give details on which SNPs (genetic variants) to check.
Use your genetic data to find out about:
- Top 10 Genes to Check using your 23andMe data
- Brain and Mood Genes
- Longevity and healthy aging
- Autoimmune disease risk and causes
Genetic Lifehacks is member supported, which means no advertisements, no selling you stuff, and no financial biases. Privacy is extremely important, and the membership is designed to keep your data private by remaining on your computer.
Not finding what you need here at Genetic Lifehacks?
OK, I know that I can’t offer everything that everyone needs. Read on for more places offering genetic reports related to health and wellness…
Where can I upload my 23andMe raw data for health analysis?
Privacy is super important when it comes to your genetic and health data:
- Figure out if your genetic data is considered a company asset.
It isn’t enough that a company says, “We don’t sell your genetic data“. Some companies’ long-term plans include storing your genetic data (and lab tests) to be bought out by a tech giant. Thus, even if a company claims it isn’t selling your data right now, you need to know if your genetic data (user data, labs, health surveys, search history, etc.) will be sold as an asset when the company changes hands.
Big overview reports on your genetic data:
The companies listed below will scan your genetic raw data file and provide links to numerous gene research initiatives. This procedure can help you figure out if your DNA contains anything rare or distinctive.
Review of Codegen (www.codegen.eu):
Overview: This website also matches your 23andMe raw data file to information on Snpedia. They have comments from other users, which may be helpful if you like anecdotes or stories.
Note: they are partnered with a company to sell you vitamins.
Review of Impute.me:
Overview: This website allows you to upload your genome and run several ‘modules’ on it. Examples include modules on drug response and rare diseases. While not as user-friendly as other websites, Impute.me has in-depth information available on very specific topics.
Price: Free (but a $5 donation is suggested)
Review of Promethease (www.promethease.com):
Overview: This website matches your 23andMe, AncestryDNA, or other genetic data to the information on the Snpedia.com website and the ClinVar database.
Price: $12 – $16
Free resources for digging into your genetic raw data file on your own:
If you want to learn more about certain health concerns using your genetic raw data file, there are a number of free resources available to help you get started.
This search engine looks up research studies relevant to specific SNPs or genes. It is convenient because it searches by both rs id and other ways researchers can reference a gene.
Review of SNPedia (www.snpedia.com):
Overview: This is a user-edited resource (like Wikipedia) with links to research papers on specific genetic variants. If you have a specific topic in mind, SNPedia.com is a good starting point.
Overview: This is the National Institutes of Health’s searchable database for medical research studies. It’s a great starting place if you know the medical terminology to search for.
Overview: This database for clinicians and researchers to use contains information on how pharmaceutical drugs interact with genetic variants.
Overview: Database of SNP information for researchers. If you have the rs id of a SNP you are interested in learning more about, plug it in here. It will give you information on the frequency in the population and links to all published research on that SNP.
Overview: From the Broad Institute, this tool allows you to input a gene name and find out which pharmaceuticals and other genes interact with that gene.
Overview: New tool from Google using their search technology to explore medical and biology research papers. Essentially, a better way to search PubMed.
Review of paid DNA reports on specific health topics:
Review of The DNA Company
Overview: The DNA Company offers reports on various health topics such as cardiovascular health, sleep, and nutrition for $399 to $4,999.
Price: $399 and up
Review of Found My Fitness :
Overview: Dr. Rhonda Patrick offers several different reports on genetics. Her podcasts are also excellent and very informative! In my opinion, what she offers is based on high-quality research studies.
Price: $25 or $15/month for membership
Review of StrateGene:
Overview: This is a color-coded report of your methylation cycle polymorphisms that is fairly comprehensive for that specific purpose. It uses 23andMe data. Strategene is part of Seeking Health, from Dr. Ben Lynch. StrateGene recommends hiring a physician to interpret the report since the report doesn’t explain what each SNP means. There is also a Facebook group for people who have paid for a report. Update: StrateGene now offers its own DNA tests as well as the ability to use other genetic data.
Review of LiveWello:
Overview: When you upload your 23andMe data, you can see the major and minor alleles for a bunch of genetic variants. Everyone (all users) can create different ‘reports’ to share with others. Livewello also has links to snpedia.com and people’s questions or comments about that gene. There are links to practitioners who you can hire.
Review of My Gene Food:
Overview: This website takes your genetic data from 23andMe or Ancestry.com and creates a custom diet plan for you based. They also have a section of recipes. While I may have personal reservations on this type of service due to research limitations on diet/gene interaction, the blog articles and information on the MyGeneFood website seem to be solidly researched and very informative.
Review of Orig3n.com:
Overview: This company offers both genetic testing and reports on several different topics. They also offer an app, ways to share your data with other people and on social media, and community interaction.
Price: $149 (test included)
Plus: “In order to provide the Services, we extract DNA from your Sample. We retain your DNA should you desire to purchase additional Services at any time. We reserve the right to retain or destroy your DNA in our discretion.”
Review of Vitagene.com
Overview: Vitagene offers health reports and DNA tests. The health reports tell you things like whether you’re likely to be lactose intolerant or should eat more greens for folate. They also include a supplement report and a recommendation on exercising.
Additionally, they share/sell all of your information “With third parties for their own services and marketing purposes, unless you opt-out of this type of sharing by submitting this form found on our “Do Not Sell My Personal Information”.
Review of Genetic Genie:
Overview: This popular website gives you a report on your methylation cycle related genes. A lot of the information is based on outdated work from various clinicians’ websites. Much of what is written is speculative and not backed by published research.
Price: $10 donation
Review of Endocanna Health (endocanna.com)
Overview: This company sells DNA testing and reports on how you are likely to respond to cannabis.
Price: $49 – $199
Finding information about genetics on Reddit
Sometimes Reddit has some interesting information about genetics, current research, or just people talking about their 23andMe results. Check out the Genetic Lifehacks article on subReddits about genetics.
Popular Genetic Lifehacks articles:
Top 10 Genes to Check in Your Genetic Raw Data
Wondering what is actually important in your genetic data? These 10 genes have important variants with a big impact on health. Check your genes (free article).
Folate & MTHFR
The MTHFR gene codes for a key enzyme in the folate cycle. MTHFR variants can decrease the conversion to methyl folate.
Chronic headaches, sinus drainage, itchy hives, problems staying asleep, and heartburn — all of these symptoms can be caused by the body not breaking down histamine very well. Your genetic variants could be causing you to be more sensitive to foods high in histamine. Check your genetic data to see if this could be at the root of your symptoms.
ACTN3: Muscle Type Gene
The ACTN3 gene codes for actinin alpha-3, a protein found in muscles. Some people don’t produce this protein, which changes the composition of their muscles.
FUT2: Are you a non-secretor of your blood type?
People with a variant in the FUT2 gene do not secrete their blood type. This variant affects the gut microbiome – and makes you immune to the norovirus.