Methylation is a process that involves moving a methyl group (a carbon plus three hydrogens, CH3) to another molecule. For example, methylation occurs in the cell nucleus where it is involved in turning on or off genes for transcription. It is also involved in converting numerous substances into their active version (e.g. melatonin) or into their inactive version. It is a process that is taking place billions of times per second throughout your body.
These methyl groups are formed, in part, through the conversion of folate to methyl folate using the gene MTHFR along with vitamin B12. The other way you can produce methyl groups is from choline.
MTHFR and Depression-We are all genetically unique, and a common genetic variant in the MTHFR gene causes some people to be more susceptible to having low folate levels. This article explains the research linking MTHFR variants, folate, and depression -- and gives you information on how diet or supplements may help.
COMT – A gene that affects your neurotransmitter levels-Wondering why your neurotransmitters are out of balance? It could be due to your COMT genetic variants. The COMT gene codes for the enzyme catechol-O-methyltransferase which breaks down (metabolizes) the neurotransmitters dopamine, epinephrine, and norepinephrine.
MTHFR and Migraines-The MTHFR C677T variant increases the risk of migraines. Learn how to check your genetic data and how to mitigate the risk.
Dads matter: MTHFR variants in fathers affect miscarriage risk-Dads matter – in conception, pregnancy, and throughout life. It is easy to see how prospective moms need to clean up their diets, exercise, and sleep well before getting pregnant, but recent studies show that a dad's MTHFR variants also affect infertility and miscarriage risk.
‘MTHFR Coffee’ with Eggs and Kale for Breakfast-Spurred on by a podcast, I share a great breakfast that supports the methylation cycle. Gelatin is an excellent source of glycine, an amino acid that is often short-changed in our modern diet. You can even add it to your morning coffee.
Supplements for Methylation and More…-It is a good idea to know what the supplements you take do inside your body. Learn about the extra additives in supplements and how to work around ones you don't want.
MTHFR C677T: Benefits of this mutation-The MTHFR C677T variant is one that has been studied extensively and there are negative risks associated with it. However, there are also protective effects from it. Learn more about the positive benefits of this variant.
MTHFR – Beyond C677T and A1298C-The MTHFR C677T and A1298C variants get a lot of press but they do not give the whole picture for the MTHFR gene. There are additional variants impacting the functionality of the enzyme.
Histamine intolerance and the methylation cycle-Genetics plays a role in how well your body breaks down histamine. Histamine that is out of balance with the body's ability to break it down can cause symptoms that are collectively known as histamine intolerance. Discover how to check your genes that are involved with histamine levels.