Methylation Cycle

Methylation is a process that involves moving a methyl group (a carbon plus three hydrogens, CH3) to another molecule. For example, methylation occurs in the cell nucleus where it is involved in turning on or off genes for transcription. It is also involved in converting numerous substances into their active version (e.g. melatonin) or into their inactive version. It is a process that is taking place billions of times per second throughout your body.

These methyl groups are formed, in part, through the conversion of folate to methyl folate using the gene MTHFR along with vitamin B12. The other way you can produce methyl groups is from choline.

Methylation cycle – Wikimedia Commons Image, Modified

The first stop in learning about your methylation cycle gene variants is:
Check Your Genetic Data for MTHFR.


Recent articles on methylation cycle genetics:

MTHFR and Depression - If you are dealing with depression, you are not alone. It is estimated that 322 million people are suffering from ... Read more
Genetic links to infertility for women - The statistics on infertility are astounding. The CDC estimates that 12% of women overall in the US have impaired fertility. For ... Read more
Choline – An Essential Nutrient - Choline is an essential nutrient that a lot of us don’t get enough of. In fact, the majority of the ... Read more
Should you vaccinate your kids if they have the MTHFR mutation? - You may have read or heard that anyone who carries MTHFR variants should not be vaccinated. Usually, the reason given ... Read more
COMT – A gene that affects your neurotransmitter levels - Having trouble with supplements containing methyl groups? Wondering why your neurotransmitters are out of balance? It could be due to ... Read more
Hacking your migraines: solutions personalized for you - Migraines plague more than a billion people worldwide and affect women three times more often than men.[ref] That is a ... Read more
Should you take folic acid if you have MTHFR variants? - There is a lot of buzz online about MTHFR variants and the need to avoid folic acid. I’ve seen recommendations ... Read more
MTHFR and Migraines - The MTHFR C677T variant increases the risk of migraines. Learn how to check your genetic data and how to mitigate the risk.
Dads matter: MTHFR variants in fathers affect miscarriage risk - Dads matter - MTHFR variants affect sperm quality and infertility risk. They also affect the risk of miscarriage.
‘MTHFR Coffee’ with Eggs and Kale for Breakfast - Quick post this morning to recommend a good podcast to anyone looking into MTHFR variants.  Chris Masterjohn put out a ... Read more
MTHFR C677T: Benefits of this mutation - Much has been written about the MTHFR C677T variant, with websites and Facebook groups named after it and proclaiming doom ... Read more
MTR / MTRR – Homocysteine, methionine, and B12 - MTR (methionine synthase) and MTRR (methionine synthase reductase) are two genes that code for enzymes that are involved in the ... Read more
Histamine intolerance and the methylation cycle - Histamine is a molecule that plays many roles in the body. It is involved in allergic reactions, plays a role ... Read more