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Addiction
- Alcohol Addiction: Exploring the Genetic and Environmental Factors
- Dopamine and Digital Addictions: Internet Use, Gaming, and Smartphones
- Opioid Receptors Genetic Variants and Addiction
- Response to Cannabis: CB1 & CB2 Genetic Variants
Alzheimer's Prevention
- Alzheimer’s and Light at Night: Taking action to prevent this disease
- APOE and COMT: Cognitive Performance in Aging
- Fibronectin, Genetics, and Alzheimer’s Prevention
- Genetic Mutations that Protect Against Alzheimer’s Disease
- Klotho VS Reduces Alzheimer’s Risk for APOE E4 Carriers
- Lion’s Mane: Cognitive function, nerve regeneration
- Lithium Orotate: Mood, Alzheimer’s, and Aging
- Melatonin Receptor Gene: Alzheimer’s Risk and Night Shift Work
- Plasmalogens: Healthy Brain Aging and More
- Prions: Genetic Mutations that Increase Prion Disease Risk
- Reelin – Long Covid, Depression, and Alzheimer’s
- Serotonin 2A receptor: Psychedelic response and Alzheimer’s disease
- SOD1 Gene: Your Antioxidant Defense System
- TREM2 and Alzheimer’s Disease Risk
- Your APOE Type and Alzheimer’s Risk: How to Find It, What It Means, and What to Do
Arrhythmia & Heart Function
- ADRA1A Receptors: Blood Vessel Reactions Under Stress
- Advanced Glycation End Products (AGEs): Genetics, Lifestyle, and Health Span
- Atrial fibrillation: Intersection of Genetic Susceptibility with Inflammation and Remodeling
- BMAL1: Core circadian gene with links to heart disease, cancer, and diabetes
- BPIFB4 Gene: Linked to Longevity and Heart Health
- Coronary Artery Disease: Genetic Susceptibility to Heart Disease
- Niacin and Heart Disease: Genetic Interaction
- Spike Protein, Mast Cells, Histamine, and Heart Rhythms
- Sudden Cardiac Death and Hypertrophic Cardiomyopathy
- TTR gene: Amyloidosis, Cardiomyopathy, hATTR CM
Articles
- 23 and Me vs Ancestry: Accuracy
- 23andMe Sale Dates: When does 23 and Me usually go on sale?
- 5 Genes That Can Help You Dial In Your Diet
- 5 ways to optimize your diet, based on your genes
- Best Reddit Forums on Genetics
- Biological Age Calculators
- Convert Your BAM/CRAM or VCF Whole Genome File to a Raw Data Format
- Converting MyHeritage .csv file to .txt
- Dante Labs Whole Genome Sequencing – Reports Review
- Dante Labs: How to Download and Convert to 23 and Me format
- Debunking the “blood-type diet”
- Dirty Genes Protocol: Book Review
- Frequently Asked Questions about 23 and Me Raw Data
- How do I check my Secretor status?
- How to Combine 23andMe and AncestryDNA Raw Data Files
- How to delete your 23andMe account
- How to delete your DNA from Ancestry.com
- How to Download Your 23andMe Raw Data
- How to download your AncestryDNA raw data
- How to login and download raw data from your 23andMe account (2026 update)
- How to Shift Your iPhone Screen to Red at Night
- Keeping Your Genetic Data Private
- Longevity Lifehacks Articles
- Nutrigenomics: Use your 23 and Me data
- Ordering Lab Tests On Your Own
- Privacy and Your Genes
- Tracking Your Vitamins and Minerals
- What happens if I have MTHFR?
- When does AncestryDNA go on sale?
Athletics & Exercise
- ACTN3 Gene: Deficiency and Muscle Type
- AMPD1 Deficiency: Post-exercise Muscle Soreness
- Athletic Performance Genes
- Creatine: Boosting Muscles and Increasing Brain Power
- HIF-1a Gene: Hypoxia, Cancer, and Athletic Superpowers
- Lactate, Lactate Dehydrogenase, and Lactate Transporters
- Motivation to Exercise: It’s Genetic.
- PPAR-Delta: Burning off the Fat
- Red Light and Photobiomodulation: ATP from Photons
- Resistance Training Genetics: Personalized Muscle Building
- Skinny Genes: Weight Loss from Aerobic Exercise
- Tendinitis (Tendonitis): Genes, Inflammation, and Targeted Solutions
Autoimmune Diseases
- Alopecia Areata: Reasons for Rapid Hair Loss
- Breast Implant Illness: The Interplay of Genetics and Symptoms
- Celiac Genes: How to Check Your Raw Data
- CTLA4 Gene: Autoimmune Risk Factor
- Familial Mediterranean Fever: MEFV Gene Variants, Overlapping Conditions, and Solutions
- Genes Involved in Autophagy
- Guillain-Barré Syndrome: Genetic Risk Factors and Known Triggers
- HLA-B27: Genetic Variant That Increases Susceptibility to Autoimmune Diseases
- IL-17: Chronic Inflammation & Autoimmune Risk with IL17A, IL17F
- Inclusion Body Myositis: Genomics and Solutions
- Low-Dose Naltrexone: LDN & Genetics
- Lupus: Genetics, Root Causes, and Possible Solutions
- Multiple Sclerosis: Genetic Factors and Susceptibility to MS
- Pernicious Anemia: Genomics and B12 Deficiency
- POTS: Genetics, Causes, and Solutions for Postural Orthostatic Tachycardia Syndrome
- Psoriasis Genes: How Genetics Point to Individualized Solutions
- PTPN22 and Autoimmune Diseases
- Raynaud’s: Causes, Symptoms, and Genetics
- Rheumatoid Arthritis: Genetics, Root Causes, and Treatment Research
- Sjogren’s: Causes, Genes, Solutions
- Thyroid Hormones: Genes, Hypothyroidism, and T4/T3 Conversion
- Tinnitus and Meniere’s Disease: Genetic Susceptibility to Ringing in Your Ears
- Vaccines, Genetics, and Autoimmune Diseases: A roundup of the research
Blood Pressure
- Blood Pressure, MTHFR, and Riboflavin
- High Blood Pressure due to AGTR1 Gene Variants
- High-fat Diet, High Blood Pressure, and the ACE Gene
- Hypertension Risk Factor: CYP11B2 Variant
- Nitric Oxide Synthase (NOS3): Heart Health, Blood Pressure, and Healthy Aging
- Salt Sensitivity and High Blood Pressure
Brain and Mood
- ADHD: Causes, Neurochemistry, and How to Check Your Genetic Raw Data
- Alcohol Addiction: Exploring the Genetic and Environmental Factors
- ANK3: Bipolar Disorder and Brain Development
- Anxiety: Genetics, heredity, and personalized solutions
- BDNF: Cognition, Stress Resilience, Introversion, and Mood
- Best Supplements to Boost BDNF
- Bipolar Disorder, Depression, and Circadian Clock Genes
- Blood-Brain Barrier Genes: SNPs, Leaky BBB Risks & Solutions
- Borderline Personality Disorder: How Genes, Trauma, and Inflammation Interact
- Brain Fog: Causes, genetics, and individualized solutions
- CBD Oil: Will it work for you?
- Circadian Rhythm Disruption as a Root Cause of Depression
- Circadian Rhythm Genes: Mood Disorders
- COMT Gene: Neurotransmitter Levels, Estrogen Metabolism, and SNPs
- COMT: How to Optimize Your Supplements for Your COMT Genotype
- Creatine: Boosting Muscles and Increasing Brain Power
- Depression, Genetics, and Mitochondrial Function
- Dopamine and Digital Addictions: Internet Use, Gaming, and Smartphones
- Dopamine Receptor SNPs: Addiction, Mood, ADHD, and Schizophrenia
- Dopamine Synthesis SNPs: Genes, lifestyle, diet, and dopamine optimization
- Dyslexia: Genes + Early Life Stressors
- GABA: Genetics, Anxiety, and Immune Response
- Genes that impact response to Modafinil
- Genetics and Intelligence: IQ-Influencing Genes and Paths to Optimization
- Genetics and Seasonal Affective Disorder
- Glutamate Receptors and Transporters
- Glutamate: Synthesis, transport, and supplement interactions
- Highly Sensitive People: Genes, Brain Function, and Sensory Sensitivity
- HPA Axis Dysfunction: Understanding Cortisol and Genetic Interactions
- Hypnosis Genes: Genetic Influences on Hypnosis
- Inflammation as a Cause of Depression and Anxiety
- Lactate, Lactate Dehydrogenase, and Lactate Transporters
- Lithium Orotate and Vitamin B12: Benefits for Mood and Cognitive Support
- MAO-A & MAO-B: Monoamine Oxidase, Warrior Gene, and Mood
- Migraine Solutions Tailored to Your Genes: Triggers, Treatments, and Tools
- MTHFR, Depression, Anxiety, Symptoms and Treatment
- Neuropilins: Neurodevelopmental Disorders, Gut Barrier, & Covid Brain
- Nootropics and Genetics: Smart Drugs and Your Genes
- OCD: Obsessive-Compulsive Disorder Genes
- Opioid Receptors Genetic Variants and Addiction
- Oxytocin Levels: Genetics of the Love Hormone
- Plasmalogens: Healthy Brain Aging and More
- Psychopaths: Born not made?
- Reelin – Long Covid, Depression, and Alzheimer’s
- Resilience: Genetic Variants Involved in Surviving Childhood Trauma
- Response to Cannabis: CB1 & CB2 Genetic Variants
- Schizophrenia: Genetic and Environmental Factors
- Serotonin 2A receptor: Psychedelic response and Alzheimer’s disease
- Serotonin: How Your Genes Affect this Neurotransmitter
- Statins and Brain Fog: Exploring how statins impact memory and cognitive function
- The Interaction Between BDNF and Serotonin
- Trace Minerals and Neurocognitive Optimization
- Tryptophan Pathways: Kynurenine, Serotonin, and Melatonin
- Underlying Cause(s) of Depression: Leveraging Your Genetic Data
- VMAT2 gene: The God Gene and Neurotransmitters
Cancer Prevention
- Aspirin, Colon Cancer Prevention, and Genetics
- BMAL1: Core circadian gene with links to heart disease, cancer, and diabetes
- BRCA1 and BRCA2 Mutations: Interactions with Environment, other Genetic Variants
- Cancer Prevention Strategies for Lynch Syndrome Mutations
- Does eating meat put you at a higher risk for colon cancer?
- FTO and m6A Methylation: Heart Health, Obesity, and Genetics
- HIF-1a Gene: Hypoxia, Cancer, and Athletic Superpowers
- MSH3 gene: Cancer Risk and DNA Repair
- PCSK9: Cancer Recurrence & Prevention
- Prostate Health: How Genes, Diet, and Lifestyle Shape Your Risk
- Skin Cancer: Genetics and Prevention
- Why Light at Night Increases Cancer Risk
Carbohydrate Metabolism
- Carbohydrate metabolism: Genetics, Insulin, and Carbs
- Digesting Carbohydrates: Amylase variants
- Do you carry the Hunter-Gatherer or the Farmer Genetic Variant
- Glucose Response: Caffeine + Sugar + Genes
Cholesterol & Lipids
- APOB gene: Apolipoprotein B Levels and Health Risks
- CoQ10: Genes, Benefits, and Mitochondrial Energy
- HDL Levels Can Be Genetic
- LDL Cholesterol: Genetics, Personalized Solutions
- Lipoprotein(a): Genetics and Lp(a) Levels
- PCSK9 Gene: Understanding the variants that cause high or low LDL cholesterol
- Plant Sterols for Lowering Cholesterol? Depends on Your Genes
- Statins and Brain Fog: Exploring how statins impact memory and cognitive function
- Triglycerides: Genes that cause high triglyceride levels
- Will statins give you muscle pain? SLCO1B1 and ABCG2
Chronic Inflammation
- Arginine: Genetics, Nitric Oxide, Immune Response, and Ammonia Clearance
- Chronic Inflammation: Causes and Natural Solutions
- Gingivitis: The Genetic Connection between Gum Disease, Inflammation, and Overall Health
- HMGB1 gene: Inflammatory Response Protein and COVID-19
- IL-13: Elevating Th2 Immune Response and Asthma risk
- IL-17: Chronic Inflammation & Autoimmune Risk with IL17A, IL17F
- IL-2 Genetics and Immune Balance
- Inflammation as a Cause of Depression and Anxiety
- Interleukin-15 (IL-15): Immune response, cancer, long Covid, and genetics
- NLRP3: Genetic Variants that Increase Chronic Inflammation
- Specialized Pro-resolving Mediators (SPMs): The Resolution of Inflammation
- TNF-alpha: Inflammation, Chronic Diseases, and Genetic Susceptibility
Clotting & Blood
- 7 Genetic Variants that Increase your Risk of Blood Clots
- ADAMTS13 and VWF Genetic Variants: blood clots and thrombocytopenia
- Aspirin, Heart Disease Prevention, and Genetics
- Blood clots, Platelets, and Adenoviruses
- Elevated Fibrinogen: Risk factor for blood clots
- Factor V Leiden Gene: Increased Risk of Blood Clots
- Genes that Impact Ferritin Levels
- Homocysteine: Genetics, High Homocysteine Levels, and Solutions
- ITGB3: PlA1/A2 variant and clotting risk
- Nattokinase and Lumbrokinase: Natural Supplements for Clotting and Heart Health
- PAI-1 (SERPINE1): Genetic Variants, Blood Clot Risk, Fibrosis, and Natural PAI-1 Inhibitors
- Prothrombin: Blood Clot Risk
- Von Willebrand Factor Deficiency: How to Check Your Raw Data
Cognitive Function
- ADHD: Causes, Neurochemistry, and How to Check Your Genetic Raw Data
- Best Supplements to Boost BDNF
- Blood-Brain Barrier Genes: SNPs, Leaky BBB Risks & Solutions
- Brain Fog: Causes, genetics, and individualized solutions
- CBD Oil: Will it work for you?
- Creatine: Boosting Muscles and Increasing Brain Power
- Dyslexia: Genes + Early Life Stressors
- Genes that impact response to Modafinil
- Genetics and Intelligence: IQ-Influencing Genes and Paths to Optimization
- Hypnosis Genes: Genetic Influences on Hypnosis
- Migraine Solutions Tailored to Your Genes: Triggers, Treatments, and Tools
- Nootropics and Genetics: Smart Drugs and Your Genes
- Plasmalogens: Healthy Brain Aging and More
- Statins and Brain Fog: Exploring how statins impact memory and cognitive function
- Trace Minerals and Neurocognitive Optimization
COVID, Long Covid, and Spike protein
- 7 Genetic Variants that Increase your Risk of Blood Clots
- Acute Respiratory Distress Syndrome Genes
- ADRA1A Receptors: Blood Vessel Reactions Under Stress
- APOBEC3 Family of Genes
- Blood clots, Platelets, and Adenoviruses
- Blood type and coronavirus susceptibility
- Brain Fog: Causes, genetics, and individualized solutions
- COVID-19 & Genetics: Who gets sick and why?
- COVID-19 and SARS-CoV2: Research Studies Related to Genetics
- Elevated Fibrinogen: Risk factor for blood clots
- Examining the Research on Vitamin D and SARS-CoV-2
- Gargling: Clinical trials on reducing respiratory infections
- Genes Linked to COVID-19: UCSF study
- Genetic Susceptibility to Viruses
- Genetic Variant Linked to Side Effects from mRNA vaccines
- Genetic variants linked to COVID-19 severity
- Guillain-Barré Syndrome: Genetic Risk Factors and Known Triggers
- HMGB1 gene: Inflammatory Response Protein and COVID-19
- Interleukin-15 (IL-15): Immune response, cancer, long Covid, and genetics
- Kawasaki Disease: Inflammatory disease in children due to pathogens
- Long Covid: 23andMe Genome Wide Association Study
- Long Covid: Genetics Research, Root Causes, and Possible Solutions
- Long Spike
- Low-Dose Naltrexone: LDN & Genetics
- Luteolin: Antihistamine, Memory, and Brain Fog
- ME/CFS and Genetics: Chronic Fatigue Syndrome Genes, Immune Pathways, and Natural Solutions
- Neuropilins: Neurodevelopmental Disorders, Gut Barrier, & Covid Brain
- NLRP3: Genetic Variants that Increase Chronic Inflammation
- PAI-1 (SERPINE1): Genetic Variants, Blood Clot Risk, Fibrosis, and Natural PAI-1 Inhibitors
- POTS: Genetics, Causes, and Solutions for Postural Orthostatic Tachycardia Syndrome
- Quercetin: Scientific Studies + Genetic Connections
- Research roundup: Preventing and mitigating COVID-19
- Research studies on melatonin and SARS-CoV-2
- Research Studies on Plant Compounds for SARS-CoV-2
- Small Fiber Neuropathy: Genetics, Causes, and Possible Solutions
- Spike Protein, Mast Cells, Histamine, and Heart Rhythms
- T Cell Exhaustion in Long COVID, ME/CFS, and Cancer: Mechanisms and Solutions
- TLR7: Susceptibility to COVID-19
- Tryptophan Pathways: Kynurenine, Serotonin, and Melatonin
Detoxification & Medication Metabolism
- ABCB1 (P-glycoprotein): Response to Medications, HRT, and Environmental Toxins
- ABCC4 (MRP4) Gene: Drug Transport, Genetic Variants, and Medication Response
- Acetaminophen Toxicity: Genetic Susceptibility and Environmental Factors
- Alcohol Metabolism: ALDH2 and ADH1B Genes
- Allergy Medicine: Why Fexofenadine Works Better for Some People
- Antibiotics: Genetics and Antibiotic Reactions
- Arsenic Metabolism Genes: Exposure, Elimination, and Ways to Reduce It
- BPA and BPS: How Your Genes Influence Bisphenol Detoxification
- CYP1A1: Detoxifying Cigarette Smoke and Estrogen
- CYP1A2 Gene: Fast or Slow Caffeine Metabolizer and More
- CYP2A6: Breaking down nicotine and other medications
- CYP2B6: Genetic Variants That Interact with Medications
- CYP2C19 Gene: SSRIs, Medications, and Toxin Metabolism
- CYP2C8 Pharmacogenetics: Ibuprofen, NSAID Risk, and Arachidonic Acid
- CYP2C9: Warfarin Dosing, NSAIDs, THC, and Drug Metabolism
- CYP2D6: Medication Interactions, Natural Inhibitors, and Anxiety Traits
- CYP2E1: Breaking down alcohol and more
- CYP2J2: Arachidonic Acid, Inflammation, and Heart Disease
- CYP3A4 Gene: Impacting Prescription Drugs, Vitamin D, and Grapefruits
- Detoxification Summary Report
- DPYD (Dihydropyrimidine Dehydrogenase) and 5-fluorouracil Reactions
- Fluoride: Health Effects And Detoxification Genes
- Getting the Lead Out: Genetics and Lead Exposure
- Glucuronidation: UGT Genetic Variants, Detoxification, and Hormone Balance
- Glutathione: Master Antioxidant, Reducing Oxidative Stress, and Detoxification
- Glyphosate Exposure: Genetics and the Impact on Our Health
- GSTM1: GST Enzymes and Glutathione for Environmental Toxins
- Gulf War Illness: Genetic Susceptibility and Current Research
- Low-Dose Naltrexone: LDN & Genetics
- Mercury Detoxification: Genomics and Solutions
- Microplastics Research Roundup
- Mold, Mycotoxins, and Your Genes: Detox Pathways, Symptoms, and SNPs
- Multiple Chemical Sensitivity (MCS): Genetics, Causes, and Solutions
- Mushroom Intolerance: Ergothioneine and the OCTN1 Gene
- NAT1 and NAT2: N-acetyltransferases and Phase II Detoxification
- NQO1 Gene: Metabolism of Quinones, Benzene, and More
- Nrf2 Pathway: Increasing the Body’s Ability to Get Rid of Toxins
- Opioid Receptors Genetic Variants and Addiction
- PFAS, Mitochondrial Function, Immune Response, and Genetics
- Phthalates: Genes, Diet, and Detoxification Pathways
- Risk of Osteonecrosis from Bisphosphonates
- Should you eat organic? Detoxifying Neonicotinoids
- Should you eat organic? Detoxifying Organophosphates
- Should you eat organic? Genes that Influence Pyrethroid Metabolism
- SOD1 Gene: Your Antioxidant Defense System
- Sulfotransferases: SULT Genes, Phase II Detoxification, and Sulfur
- Tamiflu: Genetic Reasons it May not Work for You
- Will statins give you muscle pain? SLCO1B1 and ABCG2
Detoxification of Substances
- ABCB1 (P-glycoprotein): Response to Medications, HRT, and Environmental Toxins
- ABCC4 (MRP4) Gene: Drug Transport, Genetic Variants, and Medication Response
- Acetaminophen Toxicity: Genetic Susceptibility and Environmental Factors
- Alcohol Metabolism: ALDH2 and ADH1B Genes
- Allergy Medicine: Why Fexofenadine Works Better for Some People
- Antibiotics: Genetics and Antibiotic Reactions
- Arsenic Metabolism Genes: Exposure, Elimination, and Ways to Reduce It
- BPA and BPS: How Your Genes Influence Bisphenol Detoxification
- DPYD (Dihydropyrimidine Dehydrogenase) and 5-fluorouracil Reactions
- Fluoride: Health Effects And Detoxification Genes
- Getting the Lead Out: Genetics and Lead Exposure
- Glutathione: Master Antioxidant, Reducing Oxidative Stress, and Detoxification
- Glyphosate Exposure: Genetics and the Impact on Our Health
- Gulf War Illness: Genetic Susceptibility and Current Research
- Low-Dose Naltrexone: LDN & Genetics
- Mercury Detoxification: Genomics and Solutions
- Microplastics Research Roundup
- Mold, Mycotoxins, and Your Genes: Detox Pathways, Symptoms, and SNPs
- Multiple Chemical Sensitivity (MCS): Genetics, Causes, and Solutions
- Mushroom Intolerance: Ergothioneine and the OCTN1 Gene
- Opioid Receptors Genetic Variants and Addiction
- PFAS, Mitochondrial Function, Immune Response, and Genetics
- Phthalates: Genes, Diet, and Detoxification Pathways
- Risk of Osteonecrosis from Bisphosphonates
- Should you eat organic? Detoxifying Neonicotinoids
- Should you eat organic? Detoxifying Organophosphates
- Should you eat organic? Genes that Influence Pyrethroid Metabolism
- Tamiflu: Genetic Reasons it May not Work for You
- Will statins give you muscle pain? SLCO1B1 and ABCG2
Dietary Sensitivities
- BChE gene: Nightshade sensitivity, Anesthesia risk
- Caffeine Metabolism and Your Genes
- FADS1 and FADS2: Omega-3 and Omega-6 Fatty Acids
- Oxalates: What Your Genes and Diet Say About Oxalate Health Issues
- Short-chain Acyl-CoA Dehydrogenase Deficiency
- TRPV1 Gene: Receptor for Spicy Foods, Sensing Cold, and CBD Oil
- Very Long Chain Acyl-CoA Dehydrogenase Deficiency (VLCAD)
Disease Prevention
- Age-Related Macular Degeneration Genes
- Alcohol Addiction: Exploring the Genetic and Environmental Factors
- Alpha-1 Antitrypsin Deficiency: Genetic Raw Data, Carrier Effects, Interactions with TNF
- Are Cold Sores Genetic? Who Gets Them and Why
- Aspirin, Colon Cancer Prevention, and Genetics
- Back Pain: Genetics, Root Causes, and Solutions
- BChE gene: Nightshade sensitivity, Anesthesia risk
- BH4: Tetrahydrobiopterin Synthesis, Recycling, and Genetic SNPs
- BMAL1: Core circadian gene with links to heart disease, cancer, and diabetes
- BRCA1 and BRCA2 Mutations: Interactions with Environment, other Genetic Variants
- Building Up Iron: Hemochromatosis Mutations
- Cancer Prevention Strategies for Lynch Syndrome Mutations
- Carnitine: Genetic Variants Affecting Mitochondrial Energy and Health
- Checking Your Carrier Status for Rare Genetic Diseases
- COMT in Pain Disorders
- Cystic Fibrosis: How to check to see if you are a carrier of a CFTR mutation
- Dental Implants: Genetics & Reducing the Risk of Implant Failures
- Does eating meat put you at a higher risk for colon cancer?
- Dry Eyes: Using Genetic Data to Find the Right Solutions
- Ehlers Danlos Syndrome: Genes, Types, and Treatments
- Essential Tremor: Causes and Possible Solutions
- Fibronectin, Genetics, and Alzheimer’s Prevention
- Fragile X Syndrome
- FTO and m6A Methylation: Heart Health, Obesity, and Genetics
- Gallstone Genes
- Gilbert’s Syndrome: A Genetic Disorder Causing High Bilirubin
- Gulf War Illness: Genetic Susceptibility and Current Research
- Gut Mucosal Barrier & Mucin Genes: Diet and DNA Shape Your Gut Defense
- Heat Shock Proteins: Cellular Resilience
- HIF-1a Gene: Hypoxia, Cancer, and Athletic Superpowers
- Hypophosphatasia (HPP) and the ALPL Gene
- Lymphedema: Causes and Genetic Pathways
- Malignant Hyperthermia: RYR1 Gene Mutations and Anesthesia
- MSH3 gene: Cancer Risk and DNA Repair
- Mutations common in Ashkenazi Jewish populations
- Norepinephrine: Focus, stress, genetics, and brain function
- Osteoporosis: Genetic Susceptibility and Prevention Strategies
- Pancreatitis: Genetics, Causes, and Exocrine Pancreatic Insufficiency (EPI)
- Parkinson’s Disease Risk: Genetics, Environmental Exposures, and Prevention Strategies
- PCSK9: Cancer Recurrence & Prevention
- Phenylalanine and Phenylketonuria: Mutations, Carrier Impact
- Polycythemia Vera: Understanding Inherited and Somatic Mutations behind This Rare Blood Disorder
- Primary Sclerosing Cholangitis
- Prostate Health: How Genes, Diet, and Lifestyle Shape Your Risk
- Pyruvate Dehydrogenase Deficiency – Mitochondrial Dysfunction and Lactate Production
- Risk of Osteonecrosis from Bisphosphonates
- Skin Cancer: Genetics and Prevention
- Sudden Hearing Loss: Viruses, Vaccines, and Genes
- Top 11 Genes to Check in Your Genetic Raw Data
- Trigger Points, Myofascial Pain Syndrome, and Underlying Causes
- Trimethylaminuria: FMO3 mutations that cause malodorous body odor
- TTR gene: Amyloidosis, Cardiomyopathy, hATTR CM
- Why Light at Night Increases Cancer Risk
- Wilson’s disease: ATP7B Gene Mutations and Copper Accumulation in the Brain
- Your APOE Type and Alzheimer’s Risk: How to Find It, What It Means, and What to Do
email series
- Blood clotting genotype report
- Cholesterol Genotype Report
- Homocysteine Genotype Report
- Lp(a) genotype report
- MTHFR C677T Genotype
Fertility
- Dads Matter: MTHFR Variants in Fathers Affect Miscarriage Risk
- Genetic Causes of Male Infertility
- Infertility and Genetics (for Women)
- MTHFR and Fertility: Folate Optimization for Pregnancy
- PCOS: Causes, Genetics, and Natural Solutions
- Pregnancy: How Your Genes Affect The Nutrients You Need
- Recurrent Miscarriage: Genes and Inflammation
- Trying to get pregnant? Targeted Approaches to Improving Egg Quality
- Twins: Genetic SNPs That Increase the Odds of Having Twins
Food Intolerances & Allergies
- Casein and Cow’s Milk Allergies
- Fructose Intolerance: Hereditary or Dietary?
- Genetics and Food Allergies
- Histamine Intolerance Genetics: DAO & HNMT Genes, Supplements
- Lactose Intolerance: How to Check Your Genetic Data
- Mushroom Intolerance: Ergothioneine and the OCTN1 Gene
- Nickel Allergy: Genetics, causes, natural solutions
- Tyramine Intolerance: Symptoms, High-Tyramine Foods, and Genetics
Gene Expression
- AHCY Gene: Tying together methylation and homocysteine
- Changing Your Circadian Gene Expression with Polyphenols
- FTO and m6A Methylation: Heart Health, Obesity, and Genetics
- How natural Supplements can Change Circadian Gene Expression
- Intermittent Fasting: Benefits from Changing Gene Expression
- Leveraging your Gut Microbiome to Change your Gene Expression
- miRNA: What It Is and How It Works
- SIRT3, Aging, and Mitochondrial Function
- SIRTfoods diet: Sirtuins and Turning on your Skinny Genes
Genetic Disorders
- Alpha-1 Antitrypsin Deficiency: Genetic Raw Data, Carrier Effects, Interactions with TNF
- Building Up Iron: Hemochromatosis Mutations
- Carnitine: Genetic Variants Affecting Mitochondrial Energy and Health
- Checking Your Carrier Status for Rare Genetic Diseases
- Cystic Fibrosis: How to check to see if you are a carrier of a CFTR mutation
- Fragile X Syndrome
- Gilbert’s Syndrome: A Genetic Disorder Causing High Bilirubin
- Malignant Hyperthermia: RYR1 Gene Mutations and Anesthesia
- Mutations common in Ashkenazi Jewish populations
- Phenylalanine and Phenylketonuria: Mutations, Carrier Impact
- Polycythemia Vera: Understanding Inherited and Somatic Mutations behind This Rare Blood Disorder
- Primary Sclerosing Cholangitis
- Pyruvate Dehydrogenase Deficiency – Mitochondrial Dysfunction and Lactate Production
- Top 11 Genes to Check in Your Genetic Raw Data
- Trimethylaminuria: FMO3 mutations that cause malodorous body odor
- TTR gene: Amyloidosis, Cardiomyopathy, hATTR CM
Gut Health
- Celiac Genes: How to Check Your Raw Data
- Digesting Carbohydrates: Amylase variants
- Does eating meat put you at a higher risk for colon cancer?
- Fatty Liver Disease: Genetics and Reasons for NAFLD, MAFLD
- FUT2: Check to See if You Are a Secretor or Non-Secretor
- Genetic Reasons Why Low FODMAPs Isn’t Working For You (SI Gene)
- Gut Genes: How Your Genetic Variants Impact Your Gut Microbiome
- Gut Mucosal Barrier & Mucin Genes: Diet and DNA Shape Your Gut Defense
- Histamine Intolerance Genetics: DAO & HNMT Genes, Supplements
- How Your Genes Shape Your Gut Microbiome
- Inflammatory Bowel Disease (IBD): Crohn’s, Ulcerative Colitis, Genes, and Gut Microbes
- Irritable Bowel Syndrome (IBS): Targeted Solutions Based on Your Genes
- Leaky Gut Genes: Emulsifiers in Processed Foods
- Leveraging your Gut Microbiome to Change your Gene Expression
- Mushroom Intolerance: Ergothioneine and the OCTN1 Gene
- Pancreatitis: Genetics, Causes, and Exocrine Pancreatic Insufficiency (EPI)
Heart Health
- 7 Genetic Variants that Increase your Risk of Blood Clots
- ADAMTS13 and VWF Genetic Variants: blood clots and thrombocytopenia
- ADRA1A Receptors: Blood Vessel Reactions Under Stress
- Advanced Glycation End Products (AGEs): Genetics, Lifestyle, and Health Span
- APOB gene: Apolipoprotein B Levels and Health Risks
- Aspirin, Heart Disease Prevention, and Genetics
- Atrial fibrillation: Intersection of Genetic Susceptibility with Inflammation and Remodeling
- Blood clots, Platelets, and Adenoviruses
- Blood Pressure, MTHFR, and Riboflavin
- BMAL1: Core circadian gene with links to heart disease, cancer, and diabetes
- BPIFB4 Gene: Linked to Longevity and Heart Health
- CoQ10: Genes, Benefits, and Mitochondrial Energy
- Coronary Artery Disease: Genetic Susceptibility to Heart Disease
- Elevated Fibrinogen: Risk factor for blood clots
- Factor V Leiden Gene: Increased Risk of Blood Clots
- Genes that Impact Ferritin Levels
- HDL Levels Can Be Genetic
- High Blood Pressure due to AGTR1 Gene Variants
- High-fat Diet, High Blood Pressure, and the ACE Gene
- Homocysteine: Genetics, High Homocysteine Levels, and Solutions
- Hypertension Risk Factor: CYP11B2 Variant
- ITGB3: PlA1/A2 variant and clotting risk
- Lactate, Lactate Dehydrogenase, and Lactate Transporters
- LDL Cholesterol: Genetics, Personalized Solutions
- Lipoprotein(a): Genetics and Lp(a) Levels
- Nattokinase and Lumbrokinase: Natural Supplements for Clotting and Heart Health
- Niacin and Heart Disease: Genetic Interaction
- Nitric Oxide Synthase (NOS3): Heart Health, Blood Pressure, and Healthy Aging
- PAI-1 (SERPINE1): Genetic Variants, Blood Clot Risk, Fibrosis, and Natural PAI-1 Inhibitors
- PCSK9 Gene: Understanding the variants that cause high or low LDL cholesterol
- Plant Sterols for Lowering Cholesterol? Depends on Your Genes
- Prothrombin: Blood Clot Risk
- Salt Sensitivity and High Blood Pressure
- Spike Protein, Mast Cells, Histamine, and Heart Rhythms
- Statins and Brain Fog: Exploring how statins impact memory and cognitive function
- Sudden Cardiac Death and Hypertrophic Cardiomyopathy
- Triglycerides: Genes that cause high triglyceride levels
- TTR gene: Amyloidosis, Cardiomyopathy, hATTR CM
- Von Willebrand Factor Deficiency: How to Check Your Raw Data
- Will statins give you muscle pain? SLCO1B1 and ABCG2
Hormones
- Acne: Root Causes, Genetic Variants, & Personal Solutions
- Ashwagandha: Research Backed Benefits and Side Effects
- CYP17A1: Steroid Hormone Production (Testosterone, Estrogen, and DHEA)
- DHEA and Your Weight
- Estrogen, Histamine, and Mast Cell Connections
- Estrogen: How It Is Made and How We Get Rid of It
- Fibroids: Genes, Root Causes, and Solutions
- Hormones Topic Summary
- Hot flashes in menopause: Genetics and natural solutions
- HPA Axis Dysfunction: Understanding Cortisol and Genetic Interactions
- Infertility and Genetics (for Women)
- Maca Root: Research-backed Benefits and How It Works
- Oxytocin Levels: Genetics of the Love Hormone
- PCOS: Causes, Genetics, and Natural Solutions
- PMS, PMDD, Genetics, and Solutions
- Progesterone: creation, receptors, effects, and metabolism
- Prostate Health: How Genes, Diet, and Lifestyle Shape Your Risk
- Testosterone: Genetic Variants that Impact Testosterone Levels
- Thyroid Hormones: Genes, Hypothyroidism, and T4/T3 Conversion
Infectious Disease & Immune Response
- 9 Genes that Impact the Response to Vaccines
- Acute Respiratory Distress Syndrome Genes
- Antibiotics: Genetics and Antibiotic Reactions
- APOBEC3 Family of Genes
- Are Cold Sores Genetic? Who Gets Them and Why
- Are You Genetically Less Likely To Get The Flu?
- Avoiding Getting Sick: Research-backed Ways to Prevent Covid, Colds, and Flu
- Candida Biology, Pathogenesis, and Genetic Susceptibility
- CCR5: Mutation that reduces the risk of AIDS or HIV
- Chronic Lyme: Genetic Susceptibility
- Chronic Sinus Infections: Genetics, Reasons, Solutions
- Circadian Rhythm and Your Immune Response to Viruses
- Epstein-Barr Virus: Genetic Risks, Reactivation, and Chronic Illnesses
- Flu Season: Genetics and Your Immune Response
- FUT2: Check to See if You Are a Secretor or Non-Secretor
- Genetic Susceptibility to Viruses
- Genetic Variant Linked to Side Effects from mRNA vaccines
- Genetics of Mannose-Binding Lectin (MBL) Deficiency
- How to Check Your Genetic Data for G6PD Deficiency
- ITGB3: PlA1/A2 variant and clotting risk
- Kawasaki Disease: Inflammatory disease in children due to pathogens
- Long Covid: Genetics Research, Root Causes, and Possible Solutions
- Low IgA and Selective IgA Deficiency
- Spike Protein, Mast Cells, Histamine, and Heart Rhythms
- TLR7: Susceptibility to COVID-19
- Vitamin D, Genes, and Your Immune System
Inflammation and Immune Response
- 9 Genes that Impact the Response to Vaccines
- Acne: Root Causes, Genetic Variants, & Personal Solutions
- Acupuncture and Genomics: Who is more likely to respond?
- Acute Respiratory Distress Syndrome Genes
- Alopecia Areata: Reasons for Rapid Hair Loss
- Alpha-Gal Syndrome: Meat Allergy, Tick Bites, and Genetics
- Antibiotics: Genetics and Antibiotic Reactions
- APOBEC3 Family of Genes
- Are Cold Sores Genetic? Who Gets Them and Why
- Are You Genetically Less Likely To Get The Flu?
- Arginine: Genetics, Nitric Oxide, Immune Response, and Ammonia Clearance
- Asthma Genes: Understanding your Genetic Pathways
- Avoiding Getting Sick: Research-backed Ways to Prevent Covid, Colds, and Flu
- C-Reactive Protein (CRP): Marker of Inflammation
- Can you get the COVID vaccine if you have MTHFR?
- Candida Biology, Pathogenesis, and Genetic Susceptibility
- CCR5: Mutation that reduces the risk of AIDS or HIV
- Chronic Inflammation: Causes and Natural Solutions
- Chronic Lyme: Genetic Susceptibility
- Chronic Sinus Infections: Genetics, Reasons, Solutions
- Circadian Rhythm and Your Immune Response to Viruses
- COMT in Pain Disorders
- Dental Implants: Genetics & Reducing the Risk of Implant Failures
- Epstein-Barr Virus: Genetic Risks, Reactivation, and Chronic Illnesses
- Estrogen, Histamine, and Mast Cell Connections
- Fatigue: Root Causes, Genetics, Personalized Solutions
- Fibromyalgia: Underlying Causes and Genetic Connections
- Flu Season: Genetics and Your Immune Response
- FUT2: Check to See if You Are a Secretor or Non-Secretor
- Genetic Susceptibility to Viruses
- Genetic Variant Linked to Side Effects from mRNA vaccines
- Genetic Variants that Increase Susceptibility to Lyme Disease
- Genetics of Mannose-Binding Lectin (MBL) Deficiency
- Gingivitis: The Genetic Connection between Gum Disease, Inflammation, and Overall Health
- Grass pollen: Allergies and Genes
- Hidradenitis Suppurativa: Genetic Causes and Possible Solutions
- Histamine Intolerance Genetics: DAO & HNMT Genes, Supplements
- HMGB1 gene: Inflammatory Response Protein and COVID-19
- How to Check Your Genetic Data for G6PD Deficiency
- IL-13: Elevating Th2 Immune Response and Asthma risk
- IL-17: Chronic Inflammation & Autoimmune Risk with IL17A, IL17F
- IL-2 Genetics and Immune Balance
- Inclusion Body Myositis: Genomics and Solutions
- Inflammation as a Cause of Depression and Anxiety
- Interleukin-15 (IL-15): Immune response, cancer, long Covid, and genetics
- ITGB3: PlA1/A2 variant and clotting risk
- Kawasaki Disease: Inflammatory disease in children due to pathogens
- Leveraging your Gut Microbiome to Change your Gene Expression
- Long Covid: Genetics Research, Root Causes, and Possible Solutions
- Low IgA and Selective IgA Deficiency
- Lymphedema: Causes and Genetic Pathways
- Mast Cells: MCAS, Genetics, and Solutions
- ME/CFS and Genetics: Chronic Fatigue Syndrome Genes, Immune Pathways, and Natural Solutions
- Migraine Solutions Tailored to Your Genes: Triggers, Treatments, and Tools
- MRGPRX2: Mast Cells, Itching, & Drug Hypersensitivity Reactions, Including Fluoroquinolones
- NLRP3: Genetic Variants that Increase Chronic Inflammation
- Osteoarthritis: The Role of Genetics and Natural Solutions
- POTS: Genetics, Causes, and Solutions for Postural Orthostatic Tachycardia Syndrome
- Research studies on histamine intolerance and mast cells
- Rosacea, Genetics, and Solutions
- Small Fiber Neuropathy: Genetics, Causes, and Possible Solutions
- Specialized Pro-resolving Mediators (SPMs): The Resolution of Inflammation
- Spike Protein, Mast Cells, Histamine, and Heart Rhythms
- T Cell Exhaustion in Long COVID, ME/CFS, and Cancer: Mechanisms and Solutions
- Tendinitis (Tendonitis): Genes, Inflammation, and Targeted Solutions
- Tinnitus and Meniere’s Disease: Genetic Susceptibility to Ringing in Your Ears
- TLR7: Susceptibility to COVID-19
- TNF-alpha: Inflammation, Chronic Diseases, and Genetic Susceptibility
- Trigger Points, Myofascial Pain Syndrome, and Underlying Causes
- TRPM3: The Ion Channel Behind Pain, Migraines, and ME/CFS
- TRPV1 Gene: Receptor for Spicy Foods, Sensing Cold, and CBD Oil
- Vitamin D, Genes, and Your Immune System
Longevity
- Advanced Glycation End Products (AGEs): Genetics, Lifestyle, and Health Span
- Age-Related Macular Degeneration Genes
- Alpha-Ketoglutarate (AKG) Supplements: What the Research Actually Shows [2026 Update]
- Alzheimer’s and Light at Night: Taking action to prevent this disease
- APOE and COMT: Cognitive Performance in Aging
- Aspirin, Colon Cancer Prevention, and Genetics
- Blood-Brain Barrier Genes: SNPs, Leaky BBB Risks & Solutions
- BPIFB4 Gene: Linked to Longevity and Heart Health
- Building Up Iron: Hemochromatosis Mutations
- Genes Involved in Autophagy
- Genetic Mutations that Protect Against Alzheimer’s Disease
- HMB Supplement and Muscle Mass
- Intermittent Fasting: Benefits from Changing Gene Expression
- Klotho Gene: Increased Longevity and Brain Health
- Klotho VS Reduces Alzheimer’s Risk for APOE E4 Carriers
- Longevity Genes: Hacking Healthspan Using Genomics
- Melatonin: Key to Health and Longevity
- Metformin: Longevity Research and Genetics
- Nicotinamide Riboside and NMN: Boosting NAD+ in Aging with Supplements
- Nitric Oxide Synthase (NOS3): Heart Health, Blood Pressure, and Healthy Aging
- Osteoporosis: Genetic Susceptibility and Prevention Strategies
- PAI-1 (SERPINE1): Genetic Variants, Blood Clot Risk, Fibrosis, and Natural PAI-1 Inhibitors
- Parkinson’s Disease Risk: Genetics, Environmental Exposures, and Prevention Strategies
- Rapamycin, mTOR, and Your Genes
- SIRT3, Aging, and Mitochondrial Function
- Skin Aging: Using Genomics to Solve Wrinkles and Age Spots
- Taurine: Healthspan, Mitochondrial Function, and Heart Health
- Telomere Length: How your Genes affect Telomeres and Aging
- TREM2 and Alzheimer’s Disease Risk
- Your APOE Type and Alzheimer’s Risk: How to Find It, What It Means, and What to Do
Mast Cells & Intolerances
- Alpha-Gal Syndrome: Meat Allergy, Tick Bites, and Genetics
- Asthma Genes: Understanding your Genetic Pathways
- Estrogen, Histamine, and Mast Cell Connections
- Grass pollen: Allergies and Genes
- Histamine Intolerance Genetics: DAO & HNMT Genes, Supplements
- Mast Cells: MCAS, Genetics, and Solutions
- MRGPRX2: Mast Cells, Itching, & Drug Hypersensitivity Reactions, Including Fluoroquinolones
- Research studies on histamine intolerance and mast cells
Member's Only Articles
- Autoimmune Summary Report
- Brain & Mood Summary Report
- Convert Your BAM/CRAM or VCF Whole Genome File to a Raw Data Format
- Detoxification Summary Report
- Disease Prevention Summary Report
- eBook Genotype Report
- eBook Library
- Exercise Report
- Fertility Summary Report
- Genetic Lifehacks Cheat Sheet
- Genetics & Weight Report
- Genotype (SNP) Look Up Tool
- GNB3 C825T: Obesity risk and metabolic health
- Gut Health Topic Summary Report
- Heart Health Topic Summary
- Hormones Topic Summary
- Immune System Summary Report
- Inflammation Summary Report
- Longevity Summary Report
- Member Survey: What should I write about next?
- Metabolic Health Summary Report
- Methylation Cycle Topic Summary
- Minerals and Micronutrients Topic Summary
- Mitochondria Topic Summary
- Nutrients Topic Summary Report
- Past Newsletters
- Sleep & Circadian Rhythm Topic Summary
- Sleep Report: Genetic Causes of Sleep Problems
- Summary Reports, Personalized Reports, & Lifehacks Reports
- Tools for Hacking Your Health
- Traits Summary Report
- Weight Loss Topic Summary
Metabolic Health Genetics: Blood Sugar, Weight, and Diabetes Risk
- A Sweet Tooth Without Weight Gain: FGF21 Gene
- Adenoviruses: Causing Weight Gain and Obesity
- Adiponectin levels, food choices, and genetics
- Artificial Sweeteners: Sucralose, Aspartame, and Genetic Interactions
- Blood Glucose Levels: Genetics and Blood Sugar Regulation
- Carbohydrate metabolism: Genetics, Insulin, and Carbs
- Color TV has made us fat: Melatonin, Genetics, and Light at Night
- Decrease your diabetes risk with coffee?
- Diabetes: Genetic Risk Report
- Eating Habits: Snacking and Hunger Genes
- Fatty Liver Disease: Genetics and Reasons for NAFLD, MAFLD
- FTO and m6A Methylation: Heart Health, Obesity, and Genetics
- Genetic Links to High Uric Acid and Gout
- Genetics and Type 2 Diabetes
- Ghrelin: The Hunger Hormone
- GLP-1 Genetics: How Genes Affect Appetite, Semaglutide, and Tirzepatide Response
- GLP-1: Genetic Variants Related to GLP-1 RA Medications
- Glucose Response: Caffeine + Sugar + Genes
- HbA1c: Heritability of A1C Testing
- High Blood Pressure due to AGTR1 Gene Variants
- Insulin Resistance and Genetics: Finding the Root Cause
- LDL Cholesterol: Genetics, Personalized Solutions
- Lipedema: Genes, Root Causes, Possible Solutions
- Medium Chain Acyl-CoA Dehydrogenase Deficiency: Genetics, Carriers, and Symptoms
- PCOS: Causes, Genetics, and Natural Solutions
- Picking the Right Weight Loss Diet for Your Genes
- Saturated Fat and Your Genes (ACE gene)
- SCD1: A lynchpin of metabolism
- Short-chain Acyl-CoA Dehydrogenase Deficiency
- SIRTfoods diet: Sirtuins and Turning on your Skinny Genes
- Triglycerides: Genes that cause high triglyceride levels
- Type II Diabetes – Genetic Connections
- Very Long Chain Acyl-CoA Dehydrogenase Deficiency (VLCAD)
Methylation Cycle
- AHCY Gene: Tying together methylation and homocysteine
- BHMT: Genetic Variants that Impact Methylation
- CBS Gene Variants and Low Sulfur Diet
- COMT Gene: Neurotransmitter Levels, Estrogen Metabolism, and SNPs
- COMT: How to Optimize Your Supplements for Your COMT Genotype
- Creatine: Boosting Muscles and Increasing Brain Power
- DHFR and MTHFR: Folic Acid Metabolism
- Folate Intake: How Much Is Too Much for Optimal Health?
- FOLR1 and FOLR2: Transporting Folate, Folinic Acid, and Folic Acid into Cells
- Histamine Intolerance, MTHFR, and the Methylation Cycle
- Homocysteine: Genetics, High Homocysteine Levels, and Solutions
- Methylation Cycle Topic Summary
- MTHFD1: Folate and Choline
- MTHFR and Fertility: Folate Optimization for Pregnancy
- MTHFR and Migraines
- MTHFR Gene Explained: C677T and A1298C Variants, Testing, and Solutions
- MTHFR, Depression, Anxiety, Symptoms and Treatment
- MTHFR: Going Beyond C677T and A1298C
- MTR and MTRR Genes: Methylation cycle and the need for Vitamin B12
- Riboflavin (Vitamin B2), MTHFR, and Deficiency Symptoms
- Vaccines and the MTHFR mutation
- Vitamin B12, MTR & MTRR, and Methylation
Mitochondria
- Alpha-Ketoglutarate (AKG) Supplements: What the Research Actually Shows [2026 Update]
- Arsenic Metabolism Genes: Exposure, Elimination, and Ways to Reduce It
- Biotin Deficiency: Genetic Reasons for Increasing Biotin
- Carnitine: Genetic Variants Affecting Mitochondrial Energy and Health
- CoQ10: Genes, Benefits, and Mitochondrial Energy
- Creatine: Boosting Muscles and Increasing Brain Power
- Depression, Genetics, and Mitochondrial Function
- Glutathione: Master Antioxidant, Reducing Oxidative Stress, and Detoxification
- Inclusion Body Myositis: Genomics and Solutions
- Medium Chain Acyl-CoA Dehydrogenase Deficiency: Genetics, Carriers, and Symptoms
- Mold, Mycotoxins, and Your Genes: Detox Pathways, Symptoms, and SNPs
- Multiple Sclerosis: Genetic Factors and Susceptibility to MS
- Nicotinamide Riboside and NMN: Boosting NAD+ in Aging with Supplements
- Pyruvate Dehydrogenase Deficiency – Mitochondrial Dysfunction and Lactate Production
- Red Light and Photobiomodulation: ATP from Photons
- Short-chain Acyl-CoA Dehydrogenase Deficiency
- SIRT3, Aging, and Mitochondrial Function
- Statins and Brain Fog: Exploring how statins impact memory and cognitive function
- Thiamine: Genomics, Cellular Energy, and Cognitive Function
- Trying to get pregnant? Targeted Approaches to Improving Egg Quality
- Very Long Chain Acyl-CoA Dehydrogenase Deficiency (VLCAD)
Mood & Mental Health
- ANK3: Bipolar Disorder and Brain Development
- Anxiety: Genetics, heredity, and personalized solutions
- Bipolar Disorder, Depression, and Circadian Clock Genes
- Borderline Personality Disorder: How Genes, Trauma, and Inflammation Interact
- Circadian Rhythm Disruption as a Root Cause of Depression
- Circadian Rhythm Genes: Mood Disorders
- Depression, Genetics, and Mitochondrial Function
- Genetics and Seasonal Affective Disorder
- HPA Axis Dysfunction: Understanding Cortisol and Genetic Interactions
- Inflammation as a Cause of Depression and Anxiety
- MTHFR, Depression, Anxiety, Symptoms and Treatment
- OCD: Obsessive-Compulsive Disorder Genes
- Psychopaths: Born not made?
- Reelin – Long Covid, Depression, and Alzheimer’s
- Resilience: Genetic Variants Involved in Surviving Childhood Trauma
- Schizophrenia: Genetic and Environmental Factors
- The Interaction Between BDNF and Serotonin
- Underlying Cause(s) of Depression: Leveraging Your Genetic Data
Neurological & Neurodegenerative
- Age-Related Macular Degeneration Genes
- Back Pain: Genetics, Root Causes, and Solutions
- BChE gene: Nightshade sensitivity, Anesthesia risk
- BH4: Tetrahydrobiopterin Synthesis, Recycling, and Genetic SNPs
- Essential Tremor: Causes and Possible Solutions
- Fibronectin, Genetics, and Alzheimer’s Prevention
- Gulf War Illness: Genetic Susceptibility and Current Research
- Parkinson’s Disease Risk: Genetics, Environmental Exposures, and Prevention Strategies
- Sudden Hearing Loss: Viruses, Vaccines, and Genes
- Wilson’s disease: ATP7B Gene Mutations and Copper Accumulation in the Brain
- Your APOE Type and Alzheimer’s Risk: How to Find It, What It Means, and What to Do
Neurotransmitters
- BDNF: Cognition, Stress Resilience, Introversion, and Mood
- COMT Gene: Neurotransmitter Levels, Estrogen Metabolism, and SNPs
- COMT: How to Optimize Your Supplements for Your COMT Genotype
- Dopamine Receptor SNPs: Addiction, Mood, ADHD, and Schizophrenia
- Dopamine Synthesis SNPs: Genes, lifestyle, diet, and dopamine optimization
- GABA: Genetics, Anxiety, and Immune Response
- Glutamate Receptors and Transporters
- Glutamate: Synthesis, transport, and supplement interactions
- MAO-A & MAO-B: Monoamine Oxidase, Warrior Gene, and Mood
- Neuropilins: Neurodevelopmental Disorders, Gut Barrier, & Covid Brain
- Oxytocin Levels: Genetics of the Love Hormone
- Serotonin 2A receptor: Psychedelic response and Alzheimer’s disease
- Serotonin: How Your Genes Affect this Neurotransmitter
- Tryptophan Pathways: Kynurenine, Serotonin, and Melatonin
- VMAT2 gene: The God Gene and Neurotransmitters
News and Research
Nutrients
- 5 ways to optimize your diet, based on your genes
- AHCY Gene: Tying together methylation and homocysteine
- Alcohol & Histamine Intolerance: Understanding the Connection
- Arginine: Genetics, Nitric Oxide, Immune Response, and Ammonia Clearance
- BChE gene: Nightshade sensitivity, Anesthesia risk
- BCO1 Gene: Converting Beta-Carotene to Vitamin A
- BHMT: Genetic Variants that Impact Methylation
- Biotin Deficiency: Genetic Reasons for Increasing Biotin
- Caffeine Metabolism and Your Genes
- Carbohydrate metabolism: Genetics, Insulin, and Carbs
- Carnitine: Genetic Variants Affecting Mitochondrial Energy and Health
- Casein and Cow’s Milk Allergies
- CBS Gene Variants and Low Sulfur Diet
- Choline, An Essential Nutrient Impacted By Genes
- Coffee: Benefits based on your genes
- COMT Gene: Neurotransmitter Levels, Estrogen Metabolism, and SNPs
- COMT: How to Optimize Your Supplements for Your COMT Genotype
- Creatine: Boosting Muscles and Increasing Brain Power
- Debunking the “blood-type diet”
- DHFR and MTHFR: Folic Acid Metabolism
- Digesting Carbohydrates: Amylase variants
- Do you carry the Hunter-Gatherer or the Farmer Genetic Variant
- Drug-Induced Depletions: Medications and Missing Micronutrients
- FADS1 and FADS2: Omega-3 and Omega-6 Fatty Acids
- Folate Intake: How Much Is Too Much for Optimal Health?
- Folate-rich recipes for MTHFR
- FOLR1 and FOLR2: Transporting Folate, Folinic Acid, and Folic Acid into Cells
- Foods rich in vitamin A – retinol form
- Fructose Intolerance: Hereditary or Dietary?
- Genetics and Food Allergies
- Glucose Response: Caffeine + Sugar + Genes
- Histamine Intolerance Genetics: DAO & HNMT Genes, Supplements
- Histamine Intolerance, MTHFR, and the Methylation Cycle
- Homocysteine: Genetics, High Homocysteine Levels, and Solutions
- Is intermittent fasting right for you?
- Lactose Intolerance: How to Check Your Genetic Data
- Magnesium Deficiency? Genes that Impact Magnesium Levels
- Manganese: Genetic Interactions, Diet, and Supplements
- Mediterranean Diet and Your Genes
- Methylation Cycle Topic Summary
- MMUT Gene Variants & Methylmalonic Acid: B12 Status & Genetics
- Molybdenum: Genetic Connections, Sulfur Metabolism, and Cofactor Deficiency
- MTHFD1: Folate and Choline
- MTHFR and Fertility: Folate Optimization for Pregnancy
- MTHFR and Migraines
- MTHFR Gene Explained: C677T and A1298C Variants, Testing, and Solutions
- MTHFR, Depression, Anxiety, Symptoms and Treatment
- MTHFR: Going Beyond C677T and A1298C
- MTR and MTRR Genes: Methylation cycle and the need for Vitamin B12
- Mushroom Intolerance: Ergothioneine and the OCTN1 Gene
- Nickel Allergy: Genetics, causes, natural solutions
- Nutrients Topic Summary Report
- Nutrigenomics: Use your 23 and Me data
- Oxalates: What Your Genes and Diet Say About Oxalate Health Issues
- Pregnancy: How Your Genes Affect The Nutrients You Need
- Recipes and Foods for Histamine Intolerance
- Riboflavin (Vitamin B2), MTHFR, and Deficiency Symptoms
- Saturated Fat and Your Genes (ACE gene)
- SCD1: A lynchpin of metabolism
- Selenium and Your Genes
- Short-chain Acyl-CoA Dehydrogenase Deficiency
- Thiamine: Genomics, Cellular Energy, and Cognitive Function
- TRPV1 Gene: Receptor for Spicy Foods, Sensing Cold, and CBD Oil
- Tyramine Intolerance: Symptoms, High-Tyramine Foods, and Genetics
- Vaccines and the MTHFR mutation
- Very Long Chain Acyl-CoA Dehydrogenase Deficiency (VLCAD)
- Vitamin B12, MTR & MTRR, and Methylation
- Vitamin B5 (Pantothenic Acid): Genetics, Deficiency, and Neurodegenerative Disease
- Vitamin B6: Genetics, Absorption, and Deficiency
- Vitamin C: Nutrigenomics, Transport, and Genetic Deficiency
- Vitamin D Genes
- Vitamin E, Genetics, and Inflammation
- Vitamin K: Bone Strength, Blood Clots, Calcification, and Genetics
- Which Type of Choline Works Best with Your Genes?
- Wilson’s disease: ATP7B Gene Mutations and Copper Accumulation in the Brain
- Zinc, Genetics, and Your Risk for Depression, Infection, or Diabetes
Pain & Connective Tissue
- COMT in Pain Disorders
- Dry Eyes: Using Genetic Data to Find the Right Solutions
- Ehlers Danlos Syndrome: Genes, Types, and Treatments
- Gut Mucosal Barrier & Mucin Genes: Diet and DNA Shape Your Gut Defense
- Osteoporosis: Genetic Susceptibility and Prevention Strategies
- Pancreatitis: Genetics, Causes, and Exocrine Pancreatic Insufficiency (EPI)
- Trigger Points, Myofascial Pain Syndrome, and Underlying Causes
Pain, Neurological & Musculoskeletal
- Acupuncture and Genomics: Who is more likely to respond?
- COMT in Pain Disorders
- Fatigue: Root Causes, Genetics, Personalized Solutions
- Fibromyalgia: Underlying Causes and Genetic Connections
- Inclusion Body Myositis: Genomics and Solutions
- ME/CFS and Genetics: Chronic Fatigue Syndrome Genes, Immune Pathways, and Natural Solutions
- Migraine Solutions Tailored to Your Genes: Triggers, Treatments, and Tools
- Osteoarthritis: The Role of Genetics and Natural Solutions
- POTS: Genetics, Causes, and Solutions for Postural Orthostatic Tachycardia Syndrome
- Small Fiber Neuropathy: Genetics, Causes, and Possible Solutions
- Tendinitis (Tendonitis): Genes, Inflammation, and Targeted Solutions
- Tinnitus and Meniere’s Disease: Genetic Susceptibility to Ringing in Your Ears
- Trigger Points, Myofascial Pain Syndrome, and Underlying Causes
- TRPM3: The Ion Channel Behind Pain, Migraines, and ME/CFS
Personalized Nutrition
- 5 ways to optimize your diet, based on your genes
- Alcohol & Histamine Intolerance: Understanding the Connection
- Coffee: Benefits based on your genes
- Drug-Induced Depletions: Medications and Missing Micronutrients
- Folate-rich recipes for MTHFR
- Foods rich in vitamin A – retinol form
- Is intermittent fasting right for you?
- Nutrigenomics: Use your 23 and Me data
- Recipes and Foods for Histamine Intolerance
- Saturated Fat and Your Genes (ACE gene)
- SCD1: A lynchpin of metabolism
Phase I Detoxification
- CYP1A1: Detoxifying Cigarette Smoke and Estrogen
- CYP1A2 Gene: Fast or Slow Caffeine Metabolizer and More
- CYP2A6: Breaking down nicotine and other medications
- CYP2B6: Genetic Variants That Interact with Medications
- CYP2C19 Gene: SSRIs, Medications, and Toxin Metabolism
- CYP2C8 Pharmacogenetics: Ibuprofen, NSAID Risk, and Arachidonic Acid
- CYP2C9: Warfarin Dosing, NSAIDs, THC, and Drug Metabolism
- CYP2D6: Medication Interactions, Natural Inhibitors, and Anxiety Traits
- CYP2E1: Breaking down alcohol and more
- CYP2J2: Arachidonic Acid, Inflammation, and Heart Disease
- CYP3A4 Gene: Impacting Prescription Drugs, Vitamin D, and Grapefruits
Phase II detoxification
- Glucuronidation: UGT Genetic Variants, Detoxification, and Hormone Balance
- GSTM1: GST Enzymes and Glutathione for Environmental Toxins
- NAT1 and NAT2: N-acetyltransferases and Phase II Detoxification
- NQO1 Gene: Metabolism of Quinones, Benzene, and More
- Nrf2 Pathway: Increasing the Body’s Ability to Get Rid of Toxins
- SOD1 Gene: Your Antioxidant Defense System
- Sulfotransferases: SULT Genes, Phase II Detoxification, and Sulfur
Pro Members
- Batch SNP lookup
- Case Examples: Heart Health
- Case Examples: Inflammation Summary
- Case Examples: Metabolic Health
- Case Examples: Nutrigenomics
- Diabetes: Genetic Risk Factors
- Expanded SNP Lookup Tool
- Gene Function Explorer
- Genotype Summary Report: All Topics
- Genotype Summary Report: Autoimmune
- Genotype Summary Report: Detoxification
- Genotype Summary Report: Disease Susceptibility
- Genotype Summary Report: Exercise
- Genotype Summary Report: Fertility
- Genotype Summary Report: Gut Health
- Genotype Summary Report: Heart
- Genotype Summary Report: Immune System
- Genotype Summary Report: Inflammation
- Genotype Summary Report: Longevity
- Genotype Summary Report: Metabolic Health
- Genotype Summary Report: Mood and Brain
- Genotype Summary Report: Rare Mutations
- Genotype Summary Report: Sleep and Circadian Rhythm
- Genotype Summary Report: Traits
- Genotype Summary Report: Vitamins
- Keeping Your Genetic Data Private
- PRO Member: Tools and Printables
- PRO Members: Learning Resources
- PRO: Supplement Research Connections
- PRO: Technical Resources for Helping Clients
- SNP Lookup Tools (PRO)
- Summary Reports (PRO Members)
- Unlock the Power of Genetics: Enhance Your Practice with Genetic Lifehacks PRO Membership
Recipes
- Choline-rich foods and recipe ideas
- Folate-rich recipes for MTHFR
- Foods rich in vitamin A – retinol form
- Low Histamine Mint Shake
- Low Histamine Salsa Recipe
- Low Histamine Smoothie Bowl
Skin, Hair & Connective Tissue
- Alopecia Areata: Reasons for Rapid Hair Loss
- Hidradenitis Suppurativa: Genetic Causes and Possible Solutions
- Lymphedema: Causes and Genetic Pathways
- Rosacea, Genetics, and Solutions
Sleep & Circadian Rhythm
- Alzheimer’s and Light at Night: Taking action to prevent this disease
- Bipolar Disorder, Depression, and Circadian Clock Genes
- Blue-blocking Glasses: Why? Which ones?
- BMAL1: Core circadian gene with links to heart disease, cancer, and diabetes
- Boost Slow-Wave Sleep with Glycine Before Bed
- Changing Your Circadian Gene Expression with Polyphenols
- Circadian Rhythm and Your Immune Response to Viruses
- Circadian Rhythm Disruption as a Root Cause of Depression
- Circadian Rhythm Genes: Mood Disorders
- Circadian Rhythm Genes: Our Internal Clocks
- Circadian Rhythm: Weight Loss and Meal Timing
- Color TV has made us fat: Melatonin, Genetics, and Light at Night
- DEC2 Gene: Short Sleep Mutation
- Do you Wake up at 4 AM? Genetic Variants of Morning Insomnia
- Genetics and Seasonal Affective Disorder
- Genomics and Teeth Grinding: Root Causes of Bruxism
- Histamine, Mast Cell Activation, and Early Morning Insomnia
- How natural Supplements can Change Circadian Gene Expression
- How to Shift Your iPhone Screen to Red at Night
- Increased Slow Wave Sleep
- Insomnia Solutions Based on Your Genes
- Leveraging your Gut Microbiome to Change your Gene Expression
- Melanopsin: Light response, Circadian Rhythm, and Blue Light Exposure
- Melatonin Receptor Gene: Alzheimer’s Risk and Night Shift Work
- Melatonin: Key to Health and Longevity
- Problems sleeping? Your genes can point to individualized solutions
- Restless Leg Syndrome and Periodic Limb Movement Disorder (PLMD): Genes and Solutions
- Sleep & Circadian Rhythm Topic Summary
- Snoring: Genes and Solutions
- Supplemental Melatonin: Immune Response and Inflammation
- Why Light at Night Increases Cancer Risk
SNP Snips
Supplement Research
- Agmatine: Neuropathic pain and mood
- AHCC: Mushroom Compound That Modulates NK and T Cells
- Alpha-Ketoglutarate (AKG) Supplements: What the Research Actually Shows [2026 Update]
- Ashwagandha: Research Backed Benefits and Side Effects
- Berberine: Research, Benefits, Absorption, and Genetics
- Best Supplements to Boost BDNF
- Boost Slow-Wave Sleep with Glycine Before Bed
- BPC-157: Tendon Repair and More
- Bryan Johnson’s Blueprint Protocol with Genetic Links
- C15:0 (Pentadecanoic Acid): Benefits, Food Sources, Endogenous Synthesis, and Fatty 15 Supplements
- CBD Oil: Will it work for you?
- Cordyceps: Clinical Trials, Mechanism of Action, and Genetic Connections
- Creatine: Boosting Muscles and Increasing Brain Power
- Curcumin Supplements: Decreasing Inflammation
- DAO Enzyme Supplements: Research Studies and Genetic Connections
- DHFR and MTHFR: Folic Acid Metabolism
- Examining the Research on Vitamin D and SARS-CoV-2
- Fisetin: Antioxidant and Senolytic
- Hesperidin: An Anti-inflammatory and Immune Boosting Citrus Flavonoid
- HMB Supplement and Muscle Mass
- L-theanine for anxiety: Genetics and Nature’s Chill Pill
- Lion’s Mane: Cognitive function, nerve regeneration
- Lithium Orotate and Vitamin B12: Benefits for Mood and Cognitive Support
- Lithium Orotate: Mood, Alzheimer’s, and Aging
- Luteolin: Antihistamine, Memory, and Brain Fog
- Maca Root: Research-backed Benefits and How It Works
- Metformin: Longevity Research and Genetics
- Methylene Blue: Genetic Connections and Research Studies
- Nattokinase and Lumbrokinase: Natural Supplements for Clotting and Heart Health
- Nicotinamide Riboside and NMN: Boosting NAD+ in Aging with Supplements
- Nootropics and Genetics: Smart Drugs and Your Genes
- Oxytocin and Weight Loss
- Plant Sterols for Lowering Cholesterol? Depends on Your Genes
- Quercetin: Scientific Studies + Genetic Connections
- Rapamycin, mTOR, and Your Genes
- Research studies on melatonin and SARS-CoV-2
- Resveratrol: Studies, Genetic Interactions, and Bioavailability
- Saffron Extract: What does the research show?
- Shilajit: Muscles, Bones, and Testosterone
- Sulforaphane: Studies, Genetic Connections
- Supplemental Melatonin: Immune Response and Inflammation
- Supplements with Genetic Connections
- Taurine: Healthspan, Mitochondrial Function, and Heart Health
- Thymosin Beta 4: Genetics & Supplemental Peptides
- Urolithin A for Mitochondrial Health and Muscle Function: Genetic Connections and Research Studies
- Which Type of Choline Works Best with Your Genes?
Traits: Genes for Taste, Hair, Skin & More
- ABCC11 Gene: Ear Wax and No Body Odor
- Are Your Cavities Caused by Genetics?
- Asparagus Pee: Do You have the Gene Variant to Smell It?
- Caffeine Metabolism and Your Genes
- Does Cilantro Taste like Soap to You?
- Dyslexia: Genes + Early Life Stressors
- Genetic Differences in How we Smell Things
- Genetic Superpowers Report
- Genetics and Color Blindness
- Genetics of Double Eyelashes
- Lactose Intolerance: How to Check Your Genetic Data
- Mosquito Bite Genes: Are you a mosquito magnet?
- Red Hair and the MC1R Gene
- Skin Aging: Using Genomics to Solve Wrinkles and Age Spots
- Skinny Genes: Weight Loss from Aerobic Exercise
- Taste Receptors: Bitter, Sweet, and Much More
- The Genetics Behind Gray Hair: Causes, Factors, and Natural Solutions
- Tools for Hacking Your Health
- Traits Summary Report
- Trimethylaminuria: FMO3 mutations that cause malodorous body odor
- TRPV1 Gene: Receptor for Spicy Foods, Sensing Cold, and CBD Oil
- Twins: Genetic SNPs That Increase the Odds of Having Twins
- Will you go bald? Genetics and hair loss
- Wine Preferences: How Genetic Variants Affect the Taste of Wines
Vitamins and Micronutrients
- Arginine: Genetics, Nitric Oxide, Immune Response, and Ammonia Clearance
- BCO1 Gene: Converting Beta-Carotene to Vitamin A
- Carnitine: Genetic Variants Affecting Mitochondrial Energy and Health
- Choline, An Essential Nutrient Impacted By Genes
- Magnesium Deficiency? Genes that Impact Magnesium Levels
- Manganese: Genetic Interactions, Diet, and Supplements
- MMUT Gene Variants & Methylmalonic Acid: B12 Status & Genetics
- Molybdenum: Genetic Connections, Sulfur Metabolism, and Cofactor Deficiency
- MTHFR Gene Explained: C677T and A1298C Variants, Testing, and Solutions
- Pregnancy: How Your Genes Affect The Nutrients You Need
- Selenium and Your Genes
- Thiamine: Genomics, Cellular Energy, and Cognitive Function
- Vitamin B12, MTR & MTRR, and Methylation
- Vitamin B5 (Pantothenic Acid): Genetics, Deficiency, and Neurodegenerative Disease
- Vitamin B6: Genetics, Absorption, and Deficiency
- Vitamin C: Nutrigenomics, Transport, and Genetic Deficiency
- Vitamin D Genes
- Vitamin E, Genetics, and Inflammation
- Vitamin K: Bone Strength, Blood Clots, Calcification, and Genetics
- Which Type of Choline Works Best with Your Genes?
- Wilson’s disease: ATP7B Gene Mutations and Copper Accumulation in the Brain
- Zinc, Genetics, and Your Risk for Depression, Infection, or Diabetes
Weight Loss
- A Sweet Tooth Without Weight Gain: FGF21 Gene
- Adenoviruses: Causing Weight Gain and Obesity
- Adiponectin levels, food choices, and genetics
- Blood Glucose Levels: Genetics and Blood Sugar Regulation
- BPA and BPS: How Your Genes Influence Bisphenol Detoxification
- Circadian Rhythm: Weight Loss and Meal Timing
- Color TV has made us fat: Melatonin, Genetics, and Light at Night
- DHEA and Your Weight
- Genetics & Weight Report
- Ghrelin: The Hunger Hormone
- GLP-1 Genetics: How Genes Affect Appetite, Semaglutide, and Tirzepatide Response
- GLP-1: Genetic Variants Related to GLP-1 RA Medications
- GNB3 C825T: Obesity risk and metabolic health
- Hacking BDNF for Weight Loss
- How Your Genes Shape Your Gut Microbiome
- Is intermittent fasting right for you?
- Leptin Receptors: Genetics and Hunger
- MC4R: Leptin, Melanin, Genes and Weight Gain
- Oxytocin and Weight Loss
- Picking the Right Weight Loss Diet for Your Genes
- PLIN1: Storing and Breaking Down Fat
- PPAR-Delta: Burning off the Fat
- PPARG: Regulating Fat Storage and Glucose Levels
- SCD1: A lynchpin of metabolism
- SIRTfoods diet: Sirtuins and Turning on your Skinny Genes
- Skinny Genes: Weight Loss from Aerobic Exercise
- The Endocannabinoid System and Weight Loss
- The FTO Gene and Weight
- UCP1: Brown Fat and Increased Fat Burning
- UCP2 Gene: Weight Loss and Mitochondrial Heat
- Weight Loss Topic Summary
- Weight Loss: Optimizing your diet based on your genes