Key takeaways:
~Agmatine is a compound created in the body that acts within neurons.
~ Studies show that it may be helpful for neuropathic pain, depression, and brain function.
~ Clinical trials in humans are few, though, which is something to consider when looking at the benefits of a supplement.
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What is Agmatine?
Agmatine is produced in the body from the essential amino acid L-arginine. It is found in plants, bacteria, and animals. In humans, agmatine is produced throughout the body, acting as a neurotransmitter and neuromodulator.
The amino acid L-arginine is converted to agmatine, an amine, using the enzyme agmatine decarboxylase.
In the brain, agmatine has neuroprotective effects by protecting against excitotoxicity. Some research points to it blocking the NMDA receptors and also inhibiting nitric oxide production in the brain. Protecting the brain against excess excitation may be beneficial in dementia, depression, and schizophrenia.[ref]
Research Studies and Benefits of Agmatine:
Agmatine as a supplement is being used for treating neuropathic pain, such as peripheral neuropathy or small fiber neuropathy. It has been studied for the relief of sciatica (radiating lower back pain).
It also has research for depression, and some use it as a nootropic for focus and cognitive function.
Animal studies also show that it may help with addiction, such as decreasing alcohol withdrawal symptoms.[ref] It also has anti-anxiety properties in animals.[ref]
Let’s dive into what the research shows for agmatine:
Mechanism of Action for Depression:
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