Vitamin B6 is an important co-factor in hundreds of different enzymatic reactions. Low levels of B6 are linked to an increased risk of diabetes, cardiovascular disease, neurodegenerative diseases, and cancer. B6 is also essential for reducing oxidative stress and inflammation.
For some people, low-dose, supplemental lithium orotate is a game changer when combined with vitamin B12. But other people may have little to no response. The difference may be in your genes.
Explore how neuropilin variants shape neurodevelopment, vascular permeability, gut barrier function, viral entry (SARS‑CoV‑2, EBV, CMV), and risks for autoimmunity and cancer.
Trace minerals affect neurotransmitter levels and neuroinflammation. Getting the right levels of micronutrients can help optimize neurocognitive function.
Tyramine intolerance happens when you can’t break it down. Too much tyramine can lead to a hypertensive crisis. Learn more and check your genetic raw data for results.
Explore the genetic basis of POTS, from HLA and norepinephrine transporter variants to EDS, MCAS, and long Covid connections, plus strategies to better manage symptoms.
VMAT2, the so‑called “God gene,” packages dopamine, serotonin, and other monoamines into vesicles, protecting neurons from oxidative stress and influencing risks for Parkinson’s, PTSD, alcohol dependence, and diabetes.
Plasminogen Activator Inhibitor (PAI-1) is an important enzyme in the regulation of the breakdown of blood clots and fibrosis. Genetic variants impact the amount of PAI-1.
Discover why inflammation causes depression and how your genetic variants in inflammatory genes may play a role in depression or anxiety.
Not everyone is equally susceptible to hypnosis. Learn how your genetic variants play a role in how your brain focuses and responds to hypnotic suggestions.
Green smoothies have been a health fad for quite a while now, but these health drinks can be a double-edged sword for some people due to their high oxalate content. Find out if you are genetically prone to kidney stones and what to do about it.
Ehlers-Danlos Syndromes causes changes in the way that collagen forms in the joints, ligaments, and skin. Explore the research on EDS and the genetic mutations that cause some of the subtypes of the disorder.
Explore NLRP3 inflammasome genetics: How variants drive chronic inflammation in Alzheimer’s, diabetes, and autoimmune diseases. Discover triggers, health risks, and lifehacks like zinc & vitamin D to modulate it.
The MTHFR gene is important for how your body utilizes folate (vitamin B9) for creating neurotransmitters, detoxifying toxicants, and maintaining a healthy heart. It is a key gene in the methylation cycle.
The MAOA and MAOB genes encode enzymes that break down certain neurotransmitters. People with low MAO may be prone to mood issues in certain circumstances.
High homocysteine levels are strongly linked to an increased relative risk of cardiovascular diseases. Find out how your genes impact homocysteine levels.
Mast cells are essential to your innate immune system, defending against pathogens and allergens. For some people, mast cells can be triggered too easily, giving allergy-like responses to lots of different substances.
Genetic variants in the FOLR1 and FOLR2 genes (folate receptors alpha and beta) can impact folate in the brain and in the immune response.
Methylfolate and folic acid—what’s the difference? Learn how DHFR and MTHFR variants affect folic acid metabolism, unmetabolized folic acid, cancer and autism risk, BH4 recycling, and how to choose the right supplement for your genes.
Smarter, happier, and more focused — this section pulls together the articles on how your genetic variants impact brain function and mental health. Instead of generic advice, you’ll find research‑based explanations of how specific SNPs influence neurotransmitters, mood, cognition, and addiction risk — plus practical, low‑hype options you can try. … Read more
A genetic variant in the FUT2 gene controls whether or not you secrete your blood type into your saliva and other bodily fluids, such as your intestinal mucosa. This can alter the gut microbiome – but protect against Norovirus infections.
A couple of common mutations can cause you to build up iron, leading to iron overload or hemochromatosis. It is one genetic disease where knowledge is really powerful – you can completely prevent hemochromatosis through blood donations.
Explore how MEFV mutations drive autoinflammatory flares, the overlap of FMF with fibromyalgia, gout, lupus, and MCAS, and evidence-based options from colchicine to natural anti-inflammatory strategies.
There are several genes that can influence your absorption, transport, and need for vitamin B12. Some people need higher amounts of B12, and some people thrive on different forms of B12. Take a look at your genetic data to see if you should up your intake of B12.