~ Clear Your Data ~ Understanding your data:If you have COMT rs4680 GG, you likely have faster (higher) COMT enzyme function.If you have COMT rs4680 AG, you likely have intermediate COMT enzyme function (highlighted in yellow).If you have COMT rs4680 AA, you likely have slow (lower) COMT enzyme function (highlighted in orange). The rs4633 genotype usually is inherited in conjunction with rs4680. It is included here in case your genetic data file didn’t contain rs4680. The additional COMT variants (rs6267 and rs165599) can add a little to your individual variation in COMT function. Background science:The catechol-O-methyltransferase (COMT) gene plays a critical role in the metabolic breakdown of catechols, including neurotransmitters dopamine, epinephrine, and norepinephrine, estrogen metabolites, and other substances with a catechol structure. COMT is crucial in controlling neurotransmitter levels and protecting cells from oxidative stress. The process involves the use of a methyl group, changing one substance to another, such as serotonin into melatonin. COMT and Supplement Interactions:Supplements that inhibit COMT function include natural flavonoids such as quercetin, fisetin, luteolin, rutin, and oleacein. COMT is also used in the … Read more
Estrogen – from how much is made to how it is broken down – is dependent on both genetics and lifestyle factors and affects both men and women. This article explains how estrogen is made, how it is eliminated from the body, which genes are involved, and how this influences the risk of breast cancer, prostate cancer, and fibroids.
Familial Mediterranean fever (FMF) is a genetic condition of inflammatory episodes that cause painful joints, pain in the abdomen, or pain in the chest. It is most often accompanied by a fever. FMF is often misdiagnosed as various pain-related conditions such as fibromyalgia, myofascial pain syndrome, or gouty arthritis.