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COMT in Pain Disorders

Genetic polymorphisms in COMT affect how we feel certain types of pain. These variants are linked to increased susceptibility to chronic pain disorders.

COMT Supplements Report

~ Clear Your Data ~ Understanding your data:If you have COMT rs4680 GG, you likely have faster (higher) COMT enzyme function.If you have COMT rs4680 AG,  you likely have intermediate COMT enzyme function (highlighted in yellow).If you have COMT rs4680 AA, you likely have slow (lower) COMT enzyme function (highlighted in orange). The rs4633 genotype usually is inherited in conjunction with rs4680. It is included here in case your genetic data file didn’t contain rs4680.  The additional COMT variants (rs6267 and rs165599) can add a little to your individual variation in COMT function.  Background science:The catechol-O-methyltransferase (COMT) gene plays a critical role in the metabolic breakdown of catechols, including neurotransmitters dopamine, epinephrine, and norepinephrine, estrogen metabolites, and other substances with a catechol structure. COMT is crucial in controlling neurotransmitter levels and protecting cells from oxidative stress. The process involves the use of a methyl group, changing one substance to another, such as serotonin into melatonin. COMT and Supplement Interactions:Supplements that inhibit COMT function include natural flavonoids such as quercetin, fisetin, luteolin, rutin, and oleacein. COMT is also used in the … Read more

COMT: How to Optimize Your Supplements for Your COMT Genotype

Some supplements interact with COMT variants to impact the rate at which neurotransmitters are broken down. Check your COMT genotype and discover how this may affect your reaction to different supplements or combinations of supplements.

COMT neurotransmitter levels

COMT Gene: Neurotransmitter levels and estrogen metabolism.

Wondering why your neurotransmitters are out of balance? It could be due to your COMT genetic variants. The COMT gene codes for the enzyme catechol-O-methyltransferase which breaks down (metabolizes) the neurotransmitters dopamine, epinephrine, and norepinephrine.

Estrogen: How it is made and how we get rid of it

Estrogen – from how much is made to how it is broken down – is dependent on both genetics and lifestyle factors and affects both men and women. This article explains how estrogen is made, how it is eliminated from the body, which genes are involved, and how this influences the risk of breast cancer, prostate cancer, and fibroids.

Familial Mediterranean Fever: Mimics fibromyalgia, arthritis, inflammation

Familial Mediterranean fever (FMF) is a genetic condition of inflammatory episodes that cause painful joints, pain in the abdomen, or pain in the chest. It is most often accompanied by a fever. FMF is often misdiagnosed as various pain-related conditions such as fibromyalgia, myofascial pain syndrome, or gouty arthritis.

featured image representing a scale with subtle adenovirus es on it.

Adenoviruses: Causing Weight Gain and Obesity

There have been several interesting studies linking obesity to a viral infection, specifically an adenovirus. Learn more about this virus and its association with obesity.

Nicotinamide Riboside and NMN: Boosting NAD+ in Aging

Explore the research about how nicotinamide riboside (NR) and NMN are being used to reverse aging. Learn about how your genes naturally affect your NAD+ levels and how this interacts with the aging process.

Supplements with Genetic Connections

Linking supplements and genetic SNPs so that you can more easily find out what may work for you – and what to be cautious about.

Homocysteine: Genetics and Solutions

High homocysteine levels are strongly linked to an increased relative risk of cardiovascular diseases. Find out how your genes impact homocysteine levels.

Chronic Lyme: Genetic Susceptibility

The interesting thing about Lyme disease is that the genetic variants you carry impact both how the disease affects you and how well antibiotics work for you. Learn whether your genetic variants are linked to post-treatment Lyme disease symptoms such as joint pain. (Member’s article)

Naltrexone: LDN & Genetics

The use of low dose naltrexone (LDN) can be an effective treatment for some autoimmune diseases, pain syndromes, and chronic fatigue syndrome. Learn how this opioid antagonist works on the immune system and how your genetics can play a part in its efficacy.

Genetics and Vitamin B12

There are several genes that can influence your absorption, transport, and need for vitamin B12. Some people need higher amounts of B12, and some people thrive on different forms of B12. Take a look at your genetic data to see if you should up your intake of B12.

Riboflavin (Vitamin B2), MTHFR, and Genetics

Riboflavin, or vitamin B2, is an essential cofactor for many biological pathways. Learn how to check your genetic raw data to see if you may need more riboflavin.