APOE and COMT: Cognitive performance in aging
Your APOE and COMT genotypes together may impact memory and cognitive function in older age.
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COMT in Pain Disorders
Genetic polymorphisms in COMT affect how we feel certain types of pain. These variants are linked to increased susceptibility to chronic pain disorders.
COMT Supplements Report
~ Clear Your Data ~ Understanding your data:If you have COMT rs4680 GG, you likely have faster (higher) COMT enzyme function.If you have COMT rs4680 AG, you likely have intermediate COMT enzyme function (highlighted in yellow).If you have COMT rs4680 AA, you likely have slow (lower) COMT enzyme function (highlighted in orange). The rs4633 genotype usually is inherited in conjunction with rs4680. It is included here in case your genetic data file didn’t contain rs4680. The additional COMT variants (rs6267 and rs165599) can add a little to your individual variation in COMT function. Background science:The catechol-O-methyltransferase (COMT) gene plays a critical role in the metabolic breakdown of catechols, including neurotransmitters dopamine, epinephrine, and norepinephrine, estrogen metabolites, and other substances with a catechol structure. COMT is crucial in controlling neurotransmitter levels and protecting cells from oxidative stress. The process involves the use of a methyl group, changing one substance to another, such as serotonin into melatonin. COMT and Supplement Interactions:Supplements that inhibit COMT function include natural flavonoids such as quercetin, fisetin, luteolin, rutin, and oleacein. COMT is also used in the … Read more
COMT: How to Optimize Your Supplements for Your COMT Genotype
Some supplements interact with COMT variants to impact the rate at which neurotransmitters are broken down. Check your COMT genotype and discover how this may affect your reaction to different supplements or combinations of supplements.
COMT Gene: Neurotransmitter levels and estrogen metabolism.
Wondering why your neurotransmitters are out of balance? It could be due to your COMT genetic variants. The COMT gene codes for the enzyme catechol-O-methyltransferase which breaks down (metabolizes) the neurotransmitters dopamine, epinephrine, and norepinephrine.
Rosacea, genetics, and solutions
Rosacea is a chronic inflammatory skin condition that is driven by upregulated inflammation. Learn how your genes interact with environmental factors to cause rosacea.
Dopamine Synthesis SNPs: Genes, lifestyle, diet, and dopamine optimization
Two key enzymes are needed for dopamine synthesis. Genetics, diet, and lifestyle can influence your dopamine production.
Sulfotransferases: SULT family of genes
The SULT genes help with phase II detoxification of estrogens, neurotransmitters, certain carcinogens, and steroid hormones.
ADHD Genes: Exploring the Role of Genetics, Environment, and Neurochemistry in ADHD
Discover the complex interplay of genetics and environment in ADHD susceptibility. Learn how circadian rhythm and neurotransmitter genes contribute to the disorder, and how toxicant exposure may increase risk.
Estrogen: How it is made and how we get rid of it
Estrogen – from how much is made to how it is broken down – is dependent on both genetics and lifestyle factors and affects both men and women. This article explains how estrogen is made, how it is eliminated from the body, which genes are involved, and how this influences the risk of breast cancer, prostate cancer, and fibroids.
Histamine, Mast Cell Activation, and Early Morning Insomnia
Histamine rising in the early morning hours may cause early waking insomnia. Mast cells and circadian rhythm disruption at the root.
Familial Mediterranean Fever: Mimics fibromyalgia, arthritis, inflammation
Familial Mediterranean fever (FMF) is a genetic condition of inflammatory episodes that cause painful joints, pain in the abdomen, or pain in the chest. It is most often accompanied by a fever. FMF is often misdiagnosed as various pain-related conditions such as fibromyalgia, myofascial pain syndrome, or gouty arthritis.
Adenoviruses: Causing Weight Gain and Obesity
There have been several interesting studies linking obesity to a viral infection, specifically an adenovirus. Learn more about this virus and its association with obesity.
Nicotinamide Riboside and NMN: Boosting NAD+ in Aging
Explore the research about how nicotinamide riboside (NR) and NMN are being used to reverse aging. Learn about how your genes naturally affect your NAD+ levels and how this interacts with the aging process.
Bryan Johnson’s Blueprint Protocol with Genetic Links
Overview of Bryan Johnson’s million dollar longevity protocol, with genetic insight to make it personalized and cheaper.
Supplements with Genetic Connections
Linking supplements and genetic SNPs so that you can more easily find out what may work for you – and what to be cautious about.
Hot flashes in menopause: Genetics and natural solutions
Hot flashes affect up to 80% of women going through menopause. Genetics, environment, and diet can make them worse. Target the right solutions.
Homocysteine: Genetics and Solutions
High homocysteine levels are strongly linked to an increased relative risk of cardiovascular diseases. Find out how your genes impact homocysteine levels.
Is Inflammation Causing Your Depression and Anxiety? The Science Behind the Link
Discover why inflammation causes depression and how your genetic variants in inflammatory genes may play a role in depression or anxiety.
Chronic Lyme: Genetic Susceptibility
The interesting thing about Lyme disease is that the genetic variants you carry impact both how the disease affects you and how well antibiotics work for you. Learn whether your genetic variants are linked to post-treatment Lyme disease symptoms such as joint pain. (Member’s article)