APOE and COMT: Cognitive Performance in Aging
Your APOE and COMT genotypes together may impact memory and cognitive function in older age.
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COMT in Pain Disorders
Genetic polymorphisms in COMT affect how we feel certain types of pain. These variants are linked to increased susceptibility to chronic pain disorders.
COMT: How to Optimize Your Supplements for Your COMT Genotype
Some supplements interact with COMT variants to impact the rate at which neurotransmitters are broken down. Check your COMT genotype and discover how this may affect your reaction to different supplements or combinations of supplements.
COMT Gene: Neurotransmitter Levels, Estrogen Metabolism, and SNPs
Wondering why your neurotransmitters are out of balance? It could be due to your COMT genetic variants. The COMT gene codes for the enzyme catechol-O-methyltransferase which breaks down (metabolizes) the neurotransmitters dopamine, epinephrine, and norepinephrine.
NQO1 Gene: Metabolism of Quinones, Benzene, and More
The NQO1 gene codes for an important enzyme in phase II detoxification. This enzyme is responsible for metabolizing the cancer-causing benzene (e.g. from air pollution) and cigarette toxins. Learn more and check your genes. (Member’s article)
Magnesium Deficiency? Genes that Impact Magnesium Levels
Genes like TRPM6, TRPM7, and CNNM2 affect how well your body absorbs and retains magnesium. See your genotype report for Mg deficiency and types of supplements.
2026 Guide: Tools for Analyzing Your Genetic Raw Data
This guide helps you find your best options for analyzing 23andMe, Sequencing.com, and AncestryDNA raw data. It compares major interpretation tools and genetic report services, and highlights privacy and safety tips to protect your genetic information. What to Look For in a Genetic Analysis Service: Before uploading your genetic data … Read more
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Article Directory Genetic Lifehacks Every published article on geneticlifehacks.com, grouped by topic. 502 articles · 50 topics · snapshot June 16, 2026 Expand all Collapse all Addiction4 Alzheimer's Prevention16 Arrhythmia & Heart Function10 Athletics & Exercise12 Autoimmune Diseases23 Blood Pressure6 Brain and Mood55 Cancer Prevention12 Carbohydrate Metabolism4 Cholesterol & Lipids10 Chronic … Read more
Norepinephrine: Focus, stress, genetics, and brain function
Discover how norepinephrine and your genes affect ADHD, ME/CFS, long COVID, POTS, and mood, plus evidence‑based ways to support healthy norepinephrine balance.
Dopamine and Digital Addictions: Internet Use, Gaming, and Smartphones
Genetics plays a role in susceptibility to addictive behavior, including internet and smartphone addiction. This article examines the latest fad of dopamine fasting along with genetic variants tied to internet use problems, smartphone usage disorder, and gaming disorders.
Methylation Cycle
Key takeaways: The methylation cycle runs billions of times per day in nearly every cell, providing methyl groups (one carbon atom bonded to three hydrogens) to DNA, proteins, and small molecules. These methyl groups influence everything from how your genes are expressed to how your brain produces neurotransmitters, and from … Read more
Blood-Brain Barrier Genes: SNPs, Leaky BBB Risks & Solutions
Genetic variants can increase susceptibility to blood-brain barrier (BBB) dysfunction. This can increase the risk of Alzheimer’s, ADHD, and mood disorders.
Gene Function Explorer
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Which Type of Choline Works Best with Your Genes?
Which choline supplement works best based on your PEMT, MTHFD1, and CHKA genes? Compare citicoline, alpha-GPC, PC, and betaine.
ME/CFS and Genetics: Chronic Fatigue Syndrome Genes, Immune Pathways, and Natural Solutions
Genetic variants in immune, mitochondrial, and inflammatory pathways (NK cells, NLRP3, interferon, complement, TRP channels) increase ME/CFS susceptibility. Check your genes and explore research-backed solutions.
T Cell Exhaustion in Long COVID, ME/CFS, and Cancer: Mechanisms and Solutions
T cell exhaustion reduces your immune response in chronic infections, long Covid, and cancer. Check your genes, read the new studies on interventions, and understand the mechanisms.
Histamine Intolerance Genetics: DAO & HNMT Genes, Supplements
Genetic variants in DAO and HNMT genes affect histamine breakdown. Check your AOC1, HNMT, and HDC genotype. Low-histamine diet, DAO supplements, and more.
Thiamine: Genomics, Cellular Energy, and Cognitive Function
Thiamine (vitamin B1) is essential for energy production and brain function. Learn how SLC19A2, SLC19A3, and other genes affect your need for thiamine.
Vitamin B5 (Pantothenic Acid): Genetics, Deficiency, and Neurodegenerative Disease
Pantothenic acid (vitamin B5) is essential for coenzyme A synthesis and brain energy. Learn about B5 deficiency, PANK2 mutations, and links to Alzheimer’s.
TNF-alpha: Inflammation, Chronic Diseases, and Genetic Susceptibility
TNF-alpha is a key inflammatory cytokine linked to autoimmune, cardiovascular, mood, and neurodegenerative diseases. Learn how TNF gene variants affect your risk and potential natural TNF inhibitors.
Nicotinamide Riboside and NMN: Boosting NAD+ in Aging with Supplements
Explore the research about how nicotinamide riboside (NR) and NMN are being used to reverse aging. Learn about how your genes naturally affect your NAD+ levels and how this interacts with the aging process.
PFAS, Your Genes, and Your Health: From Mitochondrial Function to Immune Response
PFAS “forever chemicals” accumulate in blood and tissue and resist normal clearance. This article covers their health effects and the genetic factors that shape individual susceptibility.
Trigger Points, Myofascial Pain Syndrome, and Underlying Causes
Trigger points are hyperirritated knots in the muscle and fascia that can refer pain to a nearby region of the body.