Tetrahydrobiopterin (BH4) is an essential cofactor in the production of neurotransmitters and nitric oxide. Genetic variants impact BH4 levels which can affect heart disease, cognitive function, and immune response.
Glyphosate is the active ingredient in the herbicide Round-Up. A recent study showed that people with CYP1A1 genetic variants are more likely to have problems with acetylcholinesterase inhibition from glyphosate.
Rosacea is a chronic inflammatory skin condition that is driven by upregulated inflammation. Learn how your genes interact with environmental factors to cause rosacea.
Biological pathways are complex to describe, and often a visual diagram makes it easier to conceptualize. This is an evolving Genetic Lifehacks project, so check back soon for more pathway diagrams and updates to current planners. Folate pathway (absorption, cellular cycles):
The MTHFD1 gene encodes an enzyme in the folate cycle. Genetic variants here can indicate a greater need for choline or folate in the diet.
Phthalates are a type of chemical used as plasticizers to make plastics more pliable. There has been a lot of research on the endocrine-disrupting effects of phthalates. Your genetic variants may impact whether phthalates are a problem for you.
Alpha-gal syndrome causes allergic reactions to meat (beef, pork, lamb) after being bitten by a tick. Find out why and which genetic pathways are involved.
Two natural fibrinolytics to reduce clotting are nattokinase and lumbrokinase. Learn more about these options based upon the newest research and clinical trials.
Estrogen – from how much is made to how it is broken down – is dependent on both genetics and lifestyle factors and affects both men and women. This article explains how estrogen is made, how it is eliminated from the body, which genes are involved, and how this influences the risk of breast cancer, prostate cancer, and fibroids.
Emulsifiers, found in many processed and packaged foods, can trigger an inflammatory response in the intestines based on whether you carry specific genetic variants.
Take a deep dive into the causes of chronic inflammation and learn how to target specific inflammatory pathways to reverse or prevent chronic disease.
Long Covid is the persistence of symptoms after having COVID-19. Learn more about the underlying causes and treatments backed by the newest research.
Wondering what is important in your raw genetic data? Check out this list of 10 genes in your 23andMe or AncestryDNA data.
Many know the frustration of disrupted sleep due to RLS and periodic limb movement disorder (PLMD). Genes play a role in your risk for these disorders, and there are specific research-based treatments to explore.
MRGPRX2 is a recently discovered mast cell receptor. It is linked to drug hypersensitivity reactions as well as asthma, rosacea, and IBD.
Hot flashes affect up to 80% of women going through menopause. Genetics, environment, and diet can make them worse. Target the right solutions.
Plasminogen Activator Inhibitor (PAI-1) is an important enzyme in the regulation of the breakdown of blood clots and fibrosis. Genetic variants impact the amount of PAI-1.
Do you feel like you are a magnet for mosquitoes? Genetic variants do play a role in how attractive you are to mosquitoes.
Fructose intolerance can be due to a rare mutation in the ALDOB gene or it can be due to reduced intestinal absorption.
Ehlers-Danlos Syndromes causes changes in the way that collagen forms in the joints, ligaments, and skin. Explore the research on EDS and the genetic mutations that cause some of the subtypes of the disorder.
What causes male pattern baldness? A combination of genetics, nutrition, and environmental toxins come together to form the risk factors for baldness. But genetics really seems to rule the roost here.
Genetic variants that increase inflammation also increase the risk of pancreatitis. Learn about causes and natural solutions for pancreas problems.
When it comes to anxiety, genetic variants combine with environmental factors (nutrition, sleep, relationships, etc) when it comes to anxiety. Understanding your anxiety genes can help you figure out which pathways to target.
Discover the pros and cons of fluoride for dental health and overall wellness, its sources, toxicity levels, and how genetics influence fluoride sensitivity.
Nickel allergy: Explore how genes, everyday exposures, and diet contribute to nickel sensitivity, including rashes, GI symptoms, and brain fog.