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News and Research: MS, remyelination, and an OTC antihistamine

Study: MWF of the corpus callosum is a robust measure of remyelination: Results from the ReBUILD trial Published: PNAS, May 2023 Overview: The study included 50 multiple sclerosis (MS patients) and looked at the brain regions that are rich in myelin.  In MS, the body attacks the myelin sheath. The study looked at ways to assess the therapeutic effect of compounds on the remyelination of neurons through imaging.  While important for researchers to know the best MRI imaging biomarkers, what I found interesting is the effect on myelin from a first-generation anti-histamine, clemastine. MRI scans were done at baseline, 3 months and 5 months. Half of the patients received clematine and the other half a placebo from months 3 to 5. The results showed that clemastine stimulated the differentiation of stem cells that make myelin.   This isn’t the first study on clemastine showing positive results for people with MS.  However, it is important in that it shows how and where the remyelination is taking place.   Clemastine used to be available OTC in the US as Dayhist Allergy and … Read more

Histamine Intolerance

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Estrogen, histamine, and mast cell connections

Mast cells can be more easily triggered in the presence of high estrogen or estrogen-mimicking compounds. Histamine can also trigger mast cell degranulation. Together, this can cause a lot of symptoms related to mast cell activation.

Luteolin: Antihistamine, Memory, and Brain Fog

New research suggests the benefits of luteolin (a flavonoid found in fruits, vegetables, and herbs) may include anti-inflammatory and neuroprotective properties.

Spike Protein, Mast Cells, Histamine, and Heart Rhythms

Do you know of someone with unexplained heart palpitations, spiking blood pressure, dizziness, and tinnitus? Discover how research is linking these symptoms to histamine, mast cells, and the spike protein.

Histamine Intolerance

Recipes and Foods for Histamine Intolerance

Interested in low histamine foods and recipes? This article focuses on foods high in histamine so you can easily eliminate them from your diet.

Histamine Intolerance, MTHFR, and the Methylation Cycle

Genetics plays a role in how well your body breaks down histamine. Histamine that is out of balance with the body’s ability to break it down can cause symptoms that are collectively known as histamine intolerance. Discover how to check your genes that are involved with histamine levels.

Low Histamine Smoothie Bowl

It can be difficult sometimes to come up with new breakfast ideas for a low histamine diet. Here is a recipe for a low histamine smoothie bowl for a quick breakfast. (Member’s article)

Low Histamine Salsa Recipe

On a low histamine diet and craving salsa and tortilla chips? Here is a quick recipe for a low histamine salsa using roasted red peppers instead of tomatoes.

Low Histamine Mint Shake

Looking for low histamine treats? Here is a mint shake recipe low in histamines, and an excellent source of luteolin, a mast cell stabilizer.

Estrogen: How it is made and how we get rid of it

Estrogen – from how much is made to how it is broken down – is dependent on both genetics and lifestyle factors and affects both men and women. This article explains how estrogen is made, how it is eliminated from the body, which genes are involved, and how this influences the risk of breast cancer, prostate cancer, and fibroids.