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Histamine Lifehacks eBook (.pdf download)

Are you struggling with symptoms like migraines, anxiety, intestinal discomfort, hives, and early morning insomnia? The culprit may be histamine intolerance or mast cell activation, two often overlooked conditions that can cause a wide range of health issues due to high histamine levels. In Histamine Lifehacks author Debbie Moon provides a comprehensive look at the role of histamine in the body and how imbalances can lead to a variety of perplexing symptoms. Drawing on the latest scientific research and her own experience, Moon explains the complex interplay between genetics, gut health, hormones, and environmental factors that can contribute to histamine-related disorders. This book goes beyond a simple low-histamine diet, offering a holistic approach to managing symptoms and getting to the root of the problem. You’ll learn about: The functions of histamine in the body and how it relates to the immune system, digestive system, respiratory system, and nervous system Genetic variations that can impact histamine metabolism The role of the gut microbiome in regulating histamine levels Environmental triggers and lifestyle factors that can exacerbate symptoms Proven strategies for reducing histamine … Read more

News and Research: MS, remyelination, and an OTC antihistamine

Study: MWF of the corpus callosum is a robust measure of remyelination: Results from the ReBUILD trial Published: PNAS, May 2023 Overview: The study included 50 multiple sclerosis (MS patients) and looked at the brain regions that are rich in myelin.  In MS, the body attacks the myelin sheath. The study looked at ways to assess the therapeutic effect of compounds on the remyelination of neurons through imaging.  While important for researchers to know the best MRI imaging biomarkers, what I found interesting is the effect on myelin from a first-generation anti-histamine, clemastine. MRI scans were done at baseline, 3 months and 5 months. Half of the patients received clematine and the other half a placebo from months 3 to 5. The results showed that clemastine stimulated the differentiation of stem cells that make myelin.   This isn’t the first study on clemastine showing positive results for people with MS.  However, it is important in that it shows how and where the remyelination is taking place.   Clemastine used to be available OTC in the US as Dayhist Allergy and … Read more

Histamine Intolerance

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Estrogen, histamine, and mast cell connections

Mast cells can be more easily triggered in the presence of high estrogen or estrogen-mimicking compounds. Histamine can also trigger mast cell degranulation. Together, this can cause a lot of symptoms related to mast cell activation.

Histamine Intolerance, MTHFR, and the Methylation Cycle

Genetics plays a role in how well your body breaks down histamine. Histamine that is out of balance with the body’s ability to break it down can cause symptoms that are collectively known as histamine intolerance. Discover how to check your genes that are involved with histamine levels.

Low Histamine Smoothie Bowl

It can be difficult sometimes to come up with new breakfast ideas for a low histamine diet. Here is a recipe for a low histamine smoothie bowl for a quick breakfast. (Member’s article)

Low Histamine Salsa Recipe

On a low histamine diet and craving salsa and tortilla chips? Here is a quick recipe for a low histamine salsa using roasted red peppers instead of tomatoes.

Low Histamine Mint Shake

Looking for low histamine treats? Here is a mint shake recipe low in histamines, and an excellent source of luteolin, a mast cell stabilizer.

Rosacea, genetics, and solutions

Rosacea is a chronic inflammatory skin condition that is driven by upregulated inflammation. Learn how your genes interact with environmental factors to cause rosacea.

Pathway Diagrams

Biological pathways are complex to describe, and often a visual diagram makes it easier to conceptualize. This is an evolving Genetic Lifehacks project, so check back soon for more pathway diagrams and updates to current planners.  Folate pathway (absorption, cellular cycles):

MTHFD1: Folate and Choline

The MTHFD1 gene encodes an enzyme in the folate cycle. Genetic variants here can indicate a greater need for choline or folate in the diet.