Mushrooms intolerance and your genes

Mushroom intolerance genes

I love mushrooms and can eat them in abundance. But I know a lot of people hate mushrooms – perhaps with a genetic reason…

Mushroom Intolerance and Crohn’s

The study, Mushroom intolerance: a novel diet-gene interaction in Crohn’s disease, was published in the British Journal of Nutrition in 2009. The study participants were a group of New Zealand Crohn’s patients and a control group without Crohn’s. The researchers were looking at the interaction between foods, disease symptoms, and genetics.

The top foods found to aggravate intestinal symptoms were corn and mushrooms. The researchers linked the ‘intolerant of mushrooms’ group to a genetic variant of the OCTN1 gene, which in previous studies had links to an increased risk of Crohn’s disease.

The OCTN1 gene

The OCTN1 gene (now known as SLC22A4) codes for a transporter of organic cations, which means it moves solutes with a positive charge across the plasma membrane. Specifically, SLC22A4 moves ergothioneine, a compound available abundantly in mushrooms, across the plasma membrane.

What is ergothioneine?

Ergothioneine has been the subject of a many research studies lately due to its antioxidant properties and potential role in helping cardiovascular disease. It is a compound that is naturally synthesized by bacteria and fungi.

We naturally consume ergothioneine in our diet in small quantities. Specific soil fungi and bacteria produce ergothioneine,  and then it is taken up by the roots of some plants. Our main food source for it is mushrooms (white button, shiitake, portobella, and oyster). Other food sources include liver, black and red beans, and oat bran.[study] It is interesting to note that in the Crohn’s study, other foods on the top offenders’ list included baked beans, chickpeas, and dried beans.

The variant of SLC22A4 linked to Crohn’s disease and, in the study referenced above, to mushroom intolerance for those with Crohn’s disease, causes a gain of function with a 50% increased transport of ergothioneine (ET).

Even though we often think of antioxidants as something to consume in abundance, the study explains:  “high levels of ET might lead to an antioxidant overload in red blood cells or epithelium, leading to pro-oxidant effects and/or imbalance in immune reaction. An alternative possibility might involve effects on pro-inflammatory cytokines or heat shock protein 70”. [ref]


Genetic variant linked to mushroom intolerance:

Members: See your data below

Login and select your data file Not a member? Join now.

The SLC22A4 variant (rs1050152) is also referred to as the OCTN1 L503F variant.

Check your genetic data for rs1050152  (23andMe v4, v5; AncestryDNA):

  • T/T: increased OCTN1 transport[ref], more likely to be intolerant of ergothioneine foods (mushrooms) with IBD
  • C/T: increased OCTN1 transport, more likely to be intolerant of ergothioneine foods (mushrooms) with IBD
  • C/C: typical

Members: Your genotype for rs1050152 is .

Note that mushroom intolerance only correlates between the SLC22A4 variant and in those with Crohn’s disease. If you don’t have any intestinal problems, you may feel perfectly fine eating mushrooms.

I find it interesting that this SLC22A4 variant is associated with the risk of Crohn’s disease and ulcerative colitis in some populations, but not all. It makes me wonder if the risk could be driven by the amount of ergothioneine in the diet either due to the popularity of mushrooms or due to local soil microbial content.


Carrier of the rs1050152  T-allele? If you have intestinal issues, and especially if you have an inflammatory bowel disease, you may want to try cutting out foods high in ergothioneine.

Foods high in ergothioneine include: [ref]

  • Many commonly eaten mushrooms including oyster, shiitake, and portobello.
  • Tempeh
  • Soy products
  • Garlic, in larger amounts
  • Asparagus
  • Brazil nuts
  • Kidney beans

Curcumin has been shown in a cell study to reduce the OCTN1 transport in cells. The research shows that when curcumin is added to the OCTN1 upregulated variant (e.g. T-allele above), the curcumin reduces OCTN1 to the levels of a normal cell. The researchers believe this is one mechanism by which curcumin is helpful in IBD. [ref]  Curcumin is available as a supplement and also in the spice turmeric.

Related Genes and Topics:

CBS variants and low sulfur
This article digs into the high quality research on the common CBS genetic variants to determine if there is any evidence suggesting everyone should be on a low-sulfur diet. Read through the research and check your genetic data.

Histamine Intolerance
Chronic headaches, sinus drainage, itchy hives, problems staying asleep, and heartburn — all of these symptoms can be caused by the body not breaking down histamine very well. Your genetic variants could be causing you to be more sensitive to foods high in histamine. Check your genetic data to see if this could be at the root of your symptoms.


Originally published 06/2017. Updated 11/2019.

Author Information:   Debbie Moon
Debbie Moon is the founder of Genetic Lifehacks. She holds a Master of Science in Biological Sciences from Clemson University. Debbie is a science communicator who is passionate about explaining evidence-based health information. Her goal with Genetic Lifehacks is to bridge the gap between scientific research and the lay person's ability to utilize that information. To contact Debbie, visit the contact page.