Acetaminophen and Liver Damage: Understanding the Role of Genetics
Discover how genetics and liver health influence acetaminophen metabolism and the risk of liver damage. Learn about the role of CD44, SULT, UGT, and GST genes.
CYP450
Estrogen: How it is made and how we get rid of it
Estrogen – from how much is made to how it is broken down – is dependent on both genetics and lifestyle factors and affects both men and women. This article explains how estrogen is made, how it is eliminated from the body, which genes are involved, and how this influences the risk of breast cancer, prostate cancer, and fibroids.
Multiple Chemical Sensitivity (MCS): Genetics, Causes, and Solutions
Struggling with Multiple Chemical Sensitivity (MCS)? Learn about the connection between genetics, detoxification enzymes, and the olfactory system. Discover how targeting specific genetic variants can help alleviate symptoms.
CYP2B6: Genetic variants impacting medication reactions
The CYP2B6 enzyme is part of the body’s first line of defense in detoxifying and breaking down certain and important for metabolizing several medications. Genetic variants of this enzyme can either speed up or slow down its function.
CYP2C19 – Metabolizing medications
Several popular drugs, such as omeprazole, esomeprazole, and clopidogrel are metabolized by the CYP2C19 enzyme. There are important genetic variants in the CYP2C19 gene that changes how fast or slowly these drugs are broken down. Learn how these variants might affect their efficacy.
Mold Genes: How Do Mycotoxins Affect You?
Exposure to certain kinds of mold can cause chronic, negative health effects. Discover how genetic variants impact the ability to handle mycotoxins.
CYP2C8: Prescription medications and arachidonic acid
The CYP2C8 gene is important in the metabolism of several chemotherapy drugs as well as playing a role in the metabolism of NSAIDs. Genetic variants that alter how this enzyme works can impact your reaction to a medication.
CYP1A2 Gene: Fast or Slow Caffeine Metabolizer?
The CYP1A2 gene breaks down caffeine, several major prescription drugs, and interacts with smoking. Learn how your genes influence caffeine metabolism and more.
CYP2D6 gene and medication reactions
The CYP2D6 enzyme is responsible for metabolizing about 25% of commonly used medications. There are several fairly common genetic variants in CYP2D6 that affect how quickly you will break down a drug.
Tyramine Intolerance: Metabolism of tyramine
Tyramine intolerance happens when you can’t break it down. Too much tyramine can lead to a hypertensive crisis. Learn more and check your genetic raw data for results.
Progesterone: creation, receptors, effects, and metabolism
Progesterone is an important hormone in women’s health. Find out how your body reacts to progesterone, breaks it down for elimination, and discover lifehacks to adjust the levels.
CYP3A4 Gene: Impacting Prescription Drugs
The CYP3A family of genes is involved in metabolizing about half of the drugs on the market today. Check your genes to see if you carry variants that impact the speed at which you metabolize medications.
CYP2C9 Genetic Variants and Drug Metabolism
Have you ever wondered why certain medications don’t work well for you? Genetic variants can change how fast or how slow the medication is broken down in your body. Learn how the CYP2C9 variants impact quite a few prescription medications.
CYP2A6: Breaking down nicotine and other medications
How many cigarettes a day a person smokes – and how hard it is for them to quit – is at least partly dependent on the CYP2A6 gene. This enzyme also metabolizes several important cancer drugs.
CYP1A1: Detoxifying Cigarette Smoke and Estrogen
This phase I detoxification gene is important in the breakdown of the hydrocarbons produced in smoke and air pollution. It also affects the metabolism of estrogen.
Should you eat organic? Detoxifying Neonicotinoids
Is buying organic worth the extra cost? Pesticides that are sprayed on conventionally grown foods affect people differently. Some people carry genetic variants that decrease their ability to detoxify specific pesticides, others may be more resilient. This is Part One in a multipart series on pesticide detoxification. (Member’s article)