The CYP450 family of enzymes is tasked with breaking down and eliminating substances in the body. These enzymes metabolize both substances produced within the body, such as estrogen, and the toxicants that we are exposed to, such as medications and pollutants.
CYP2A6 is part of the CYP450 family of genes that code for the detoxification enzymes. The CYP2A6 enzyme is involved in the metabolism, or breaking down, of:
The estrogen hormone, estradiol, causes higher CYP2A6 activity, and women usually have a somewhat higher activity of this enzyme.[ref]
When it comes to smoking, the CYP2A6 genetic variants impact the speed at which nicotine is metabolized. Interestingly, researchers link the genetic variants of CYP2A6 that cause decreased enzyme activity with a lower level of dependence in smokers, making it easier for them to quit. Basically, the slower CYP2A6 variants make the effects of nicotine last longer, thus reducing the number of cigarettes smoked.
On the other hand, people with increased CYP2A6 enzyme activity have an enhanced metabolism of nicotine and are likely to smoke more cigarettes per day.[ref]
There are quite a few variations of CYP2A6. Below are just a few that are available in common genetic sequencing.
In general, research shows that people with reduced (or slow) CYP2A6 activity are more likely to quit smoking. Amongst smokers, slow CYP2A6 activity is linked with smoking fewer cigarettes per day.[ref][ref]
Check your genetic data for rs1801272 (23andMe v4; AncestryDNA):
*note: listed in the plus orientation to match 23andMe, AncestryDNA data
Check your genetic data for rs5031017 (23andMe v4 only):
Check your genetic data for rs5031016 (23andMe v4, v5; AncestryDNA):
Check your genetic data for rs28399444 (23andMe v4 only):
Another gene, POR (P450 cytochrome oxidoreductase), codes for an enzyme that can also alter the activity of other CYP450 enzymes.
Check your genetic data for rs1057868 (23andMe v4, v5; AncestryDNA):
Grapefruit juice contains a substance that inhibits CYP2A6 enzyme activity. So be careful – especially if you have a slow variant of the gene – with combining grapefruit juice with any drug that is metabolized by CYP2A6.[ref]
Higher doses of cinnamon, such as you might take for regulating blood sugar levels, has been shown to inhibit CYP2A6 enzyme activity.[ref] If you are a slower CYP2A6 metabolizer, you may want to be careful about too much cinnamon if you also take one of the medications listed below.
Drugs that are metabolized by CYP2A6 include: [ref – read for more info]
Check out the substrates column the CYP2A6 article on Wikipedia for more drugs and substances metabolized by CYP2A6.
More to read:
This is part of an ongoing series on the genes involved in Phase I detoxification.